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Summary Expression Phenotypes Gene Literature (31) GO Terms (9) Nucleotides (149) Proteins (61) Interactants (75) Wiki
XB-GENEPAGE-483435

Papers associated with slc12a5



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Human iPSC Modeling of Genetic Febrile Seizure Reveals Aberrant Molecular and Physiological Features Underlying an Impaired Neuronal Activity., Scalise S, Zannino C, Lucchino V, Lo Conte M, Scaramuzzino L, Cifelli P, D'Andrea T, Martinello K, Fucile S, Palma E, Gambardella A, Ruffolo G, Cuda G, Parrotta EI., Biomedicines. May 5, 2022; 10 (5):


Developmental gene expression patterns in the brain and liver of Xenopus tropicalis during metamorphosis climax., Yaoita Y, Nakajima K., Genes Cells. December 1, 2018; 23 (12): 998-1008.              

A novel GABAergic dysfunction in human Dravet syndrome., Ruffolo G, Cifelli P, Roseti C, Thom M, van Vliet EA, Limatola C, Aronica E, Palma E., Epilepsia. November 1, 2018; 59 (11): 2106-2117.

Cotransporter-mediated water transport underlying cerebrospinal fluid formation., Steffensen AB, Oernbo EK, Stoica A, Gerkau NJ, Barbuskaite D, Tritsaris K, Rose CR, MacAulay N., Nat Commun. June 4, 2018; 9 (1): 2167.              

Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions., Ruffolo G, Iyer A, Cifelli P, Roseti C, Mühlebner A, van Scheppingen J, Scholl T, Hainfellner JA, Feucht M, Krsek P, Zamecnik J, Jansen FE, Spliet WG, Limatola C, Aronica E, Palma E., Neurobiol Dis. November 1, 2016; 95 93-101.

Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics., Salin-Cantegrel A, Shekarabi M, Rasheed S, Charron FM, Laganière J, Gaudet R, Dion PA, Lapointe JY, Rouleau GA., PLoS One. May 15, 2013; 8 (5): e65294.            

A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function., Ding J, Ponce-Coria J, Delpire E., PLoS One. January 1, 2013; 8 (4): e61112.                    

Hyperpolarizing GABAergic transmission requires the KCC2 C-terminal ISO domain., Acton BA, Mahadevan V, Mercado A, Uvarov P, Ding Y, Pressey J, Airaksinen MS, Mount DB, Woodin MA., J Neurosci. June 20, 2012; 32 (25): 8746-51.

Regulation of spinal interneuron differentiation by the paracrine action of glycine., Côté S, Drapeau P., Dev Neurobiol. February 1, 2012; 72 (2): 208-14.

GABA reverse transport by the neuronal cotransporter GAT1: influence of internal chloride depletion., Bertram S, Cherubino F, Bossi E, Castagna M, Peres A., Am J Physiol Cell Physiol. November 1, 2011; 301 (5): C1064-73.

Anomalous levels of Cl- transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex., Conti L, Palma E, Roseti C, Lauro C, Cipriani R, de Groot M, Aronica E, Limatola C., Epilepsia. September 1, 2011; 52 (9): 1635-44.

WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., J Biol Chem. August 26, 2011; 286 (34): 30171-80.              

Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain., Hekmat-Scafe DS, Mercado A, Fajilan AA, Lee AW, Hsu R, Mount DB, Tanouye MA., Genetics. January 1, 2010; 184 (1): 171-83.

HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3., Salin-Cantegrel A, Shekarabi M, Holbert S, Dion P, Rochefort D, Laganière J, Dacal S, Hince P, Karemera L, Gaspar C, Lapointe JY, Rouleau GA., Hum Mol Genet. September 1, 2008; 17 (17): 2703-11.

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases., Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. June 17, 2008; 105 (24): 8458-63.

Neurogenic role of the depolarizing chloride gradient revealed by global overexpression of KCC2 from the onset of development., Reynolds A, Brustein E, Liao M, Mercado A, Babilonia E, Mount DB, Drapeau P., J Neurosci. February 13, 2008; 28 (7): 1588-97.

Characterization of an extracellular epitope antibody to the neuronal K-Cl cotransporter, KCC2., Gagnon KB, Fyffe RE, Adragna NC, Lauf PK., Clin Exp Pharmacol Physiol. July 1, 2007; 34 (7): 566-73.

Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransporters., Simard CF, Bergeron MJ, Frenette-Cotton R, Carpentier GA, Pelchat ME, Caron L, Isenring P., J Biol Chem. June 22, 2007; 282 (25): 18083-18093.

WNK4 kinase is a negative regulator of K+-Cl- cotransporters., Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.

Identification of key functional domains in the C terminus of the K+-Cl- cotransporters., Bergeron MJ, Gagnon E, Caron L, Isenring P., J Biol Chem. June 9, 2006; 281 (23): 15959-69.

Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory., Palma E, Amici M, Sobrero F, Spinelli G, Di Angelantonio S, Ragozzino D, Mascia A, Scoppetta C, Esposito V, Miledi R, Eusebi F., Proc Natl Acad Sci U S A. May 30, 2006; 103 (22): 8465-8.

Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo., Akerman CJ, Cline HT., J Neurosci. May 10, 2006; 26 (19): 5117-30.

A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport., Mercado A, Broumand V, Zandi-Nejad K, Enck AH, Mount DB., J Biol Chem. January 13, 2006; 281 (2): 1016-26.

Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4., Gagnon KB, England R, Delpire E., Am J Physiol Cell Physiol. January 1, 2006; 290 (1): C134-42.

WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability., Kahle KT, Rinehart J, de Los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16783-8.

Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters., Bergeron MJ, Gagnon E, Wallendorff B, Lapointe JY, Isenring P., Am J Physiol Renal Physiol. July 1, 2003; 285 (1): F68-78.

Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter., Song L, Mercado A, Vázquez N, Xie Q, Desai R, George AL, Gamba G, Mount DB., Brain Res Mol Brain Res. June 30, 2002; 103 (1-2): 91-105.

A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity., Casula S, Shmukler BE, Wilhelm S, Stuart-Tilley AK, Su W, Chernova MN, Brugnara C, Alper SL., J Biol Chem. November 9, 2001; 276 (45): 41870-8.

Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4., Mercado A, Song L, Vazquez N, Mount DB, Gamba G., J Biol Chem. September 29, 2000; 275 (39): 30326-34.

Dependence of KCC2 K-Cl cotransporter activity on a conserved carboxy terminus tyrosine residue., Strange K, Singer TD, Morrison R, Delpire E., Am J Physiol Cell Physiol. September 1, 2000; 279 (3): C860-7.

Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family., Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G., J Biol Chem. June 4, 1999; 274 (23): 16355-62.

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