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Summary Expression Phenotypes Gene Literature (66) GO Terms (8) Nucleotides (163) Proteins (51) Interactants (708) Wiki
XB--487419

Papers associated with smo



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The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants., Hardcastle Z, Mo R, Hui CC, Sharpe PT., Development. August 1, 1998; 125 (15): 2803-11.

Smoothened activates Galphai-mediated signaling in frog melanophores., DeCamp DL, Thompson TM, de Sauvage FJ, Lerner MR., J Biol Chem. August 25, 2000; 275 (34): 26322-7.

Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus., Zhang J, Rosenthal A, de Sauvage FJ, Shivdasani RA., Dev Biol. January 1, 2001; 229 (1): 188-202.                  

Molecular cloning and expression analysis of the Hedgehog receptors XPtc1 and XSmo in Xenopus laevis., Koebernick K, Hollemann T, Pieler T., Mech Dev. February 1, 2001; 100 (2): 303-8.  

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node., Zhang XM, Ramalho-Santos M, McMahon AP., Cell. June 15, 2001; 105 (6): 781-92.

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains., Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ., Nature. July 5, 2001; 412 (6842): 86-90.

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node., Zhang XM, Ramalho-Santos M, McMahon AP., Cell. July 27, 2001; 106 (2): 781-92.

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord., Wijgerde M, McMahon JA, Rule M, McMahon AP., Genes Dev. November 15, 2002; 16 (22): 2849-64.

Hedgehog signalling maintains the optic stalk-retinal interface through the regulation of Vax gene activity., Take-uchi M, Clarke JD, Wilson SW., Development. March 1, 2003; 130 (5): 955-68.

A novel function for Hedgehog signalling in retinal pigment epithelium differentiation., Perron M, Boy S, Amato MA, Viczian A, Koebernick K, Pieler T, Harris WA., Development. April 1, 2003; 130 (8): 1565-77.                                  

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance., Charron F, Stein E, Jeong J, McMahon AP, Tessier-Lavigne M., Cell. April 4, 2003; 113 (1): 11-23.

A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos., Stancheva I, Collins AL, Van den Veyver IB, Zoghbi H, Meehan RR., Mol Cell. August 1, 2003; 12 (2): 425-35.                          

A restrictive role for Hedgehog signalling during otic specification in Xenopus., Koebernick K, Hollemann T, Pieler T., Dev Biol. August 15, 2003; 260 (2): 325-38.              

Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase., Koide T, Hayata T, Cho KW., Development. June 1, 2006; 133 (12): 2395-405.                

Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursors., Locker M, Agathocleous M, Amato MA, Parain K, Harris WA, Perron M., Genes Dev. November 1, 2006; 20 (21): 3036-48.

Suppressing Wnt signaling by the hedgehog pathway through sFRP-1., He J, Sheng T, Stelter AA, Li C, Zhang X, Sinha M, Luxon BA, Xie J., J Biol Chem. November 24, 2006; 281 (47): 35598-602.

PP2A:B56epsilon is required for eye induction and eye field separation., Rorick AM, Mei W, Liette NL, Phiel C, El-Hodiri HM, Yang J., Dev Biol. February 15, 2007; 302 (2): 477-93.                  

Two oppositely localised frizzled RNAs as axis determinants in a cnidarian embryo., Momose T, Houliston E., PLoS Biol. April 1, 2007; 5 (4): e70.                

Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling., Harada Y, Yokota C, Habas R, Slusarski DC, He X., Biochem Biophys Res Commun. July 13, 2007; 358 (4): 968-75.        

Enabled (Xena) regulates neural plate morphogenesis, apical constriction, and cellular adhesion required for neural tube closure in Xenopus., Roffers-Agarwal J, Xanthos JB, Kragtorp KA, Miller JR., Dev Biol. February 15, 2008; 314 (2): 393-403.            

Effects of activation of hedgehog signaling on patterning, growth, and differentiation in Xenopus froglet limb regeneration., Yakushiji N, Suzuki M, Satoh A, Ide H, Tamura K, Tamura K., Dev Dyn. August 1, 2009; 238 (8): 1887-96.          

Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain., Zhao L, Saitsu H, Sun X, Shiota K, Ishibashi M., Mech Dev. January 1, 2010; 127 (1-2): 62-72.                

Xenopus sonic hedgehog guides retinal axons along the optic tract., Gordon L, Mansh M, Kinsman H, Morris AR., Dev Dyn. November 1, 2010; 239 (11): 2921-32.      

[Passive and active reactions of embryonic tissues to the action of dosed mechanical forces]., Mansurov AN, Belousov LV., Ontogenez. January 1, 2011; 42 (2): 126-32.

A conserved function of the chromatin ATPase Kismet in the regulation of hedgehog expression., Terriente-Félix A, Molnar C, Gómez-Skarmeta JL, de Celis JF., Dev Biol. February 15, 2011; 350 (2): 382-92.                  

Knockdown of SPARC leads to decreased cell-cell adhesion and lens cataracts during post-gastrula development in Xenopus laevis., Huynh MH, Zhu SJ, Kollara A, Brown T, Winklbauer R, Ringuette M., Dev Genes Evol. March 1, 2011; 220 (11-12): 315-27.

Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord., Belgacem YH, Borodinsky LN., Proc Natl Acad Sci U S A. March 15, 2011; 108 (11): 4482-7.        

MIM regulates vertebrate neural tube closure., Liu W, Komiya Y, Mezzacappa C, Khadka DK, Runnels L, Habas R., Development. May 1, 2011; 138 (10): 2035-47.                            

Thyroid hormone-induced sonic hedgehog signal up-regulates its own pathway in a paracrine manner in the Xenopus laevis intestine during metamorphosis., Hasebe T, Kajita M, Fu L, Shi YB, Ishizuya-Oka A., Dev Dyn. February 1, 2012; 241 (2): 403-14.        

Indian hedgehog signaling is required for proper formation, maintenance and migration of Xenopus neural crest., Agüero TH, Fernández JP, López GA, Tríbulo C, Aybar MJ., Dev Biol. April 15, 2012; 364 (2): 99-113.                    

Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros., Zhang B, Romaker D, Ferrell N, Wessely O., Dev Biol. April 1, 2013; 376 (1): 31-42.                        

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling., Nedelcu D, Liu J, Xu Y, Xu Y, Jao C, Salic A., Nat Chem Biol. September 1, 2013; 9 (9): 557-64.          

Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling., Schwend T, Jin Z, Jiang K, Mitchell BJ, Jia J, Yang J., J Biol Chem. November 8, 2013; 288 (45): 32809-32820.                

Reagents for developmental regulation of Hedgehog signaling., Lewis C, Krieg PA., Methods. April 1, 2014; 66 (3): 390-7.

MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney., Romaker D, Kumar V, Cerqueira DM, Cox RM, Wessely O., Proc Natl Acad Sci U S A. April 29, 2014; 111 (17): 6335-40.                                                          

Sulf1 influences the Shh morphogen gradient during the dorsal ventral patterning of the neural tube in Xenopus tropicalis., Ramsbottom SA, Maguire RJ, Fellgett SW, Pownall ME., Dev Biol. July 15, 2014; 391 (2): 207-18.                  

Neural transcription factors: from embryos to neural stem cells., Lee HK, Lee HS, Moody SA., Mol Cells. October 31, 2014; 37 (10): 705-12.    

Chibby functions in Xenopus ciliary assembly, embryonic development, and the regulation of gene expression., Shi J, Zhao Y, Galati D, Winey M, Klymkowsky MW., Dev Biol. November 15, 2014; 395 (2): 287-98.                    

Early development of the neural plate: new roles for apoptosis and for one of its main effectors caspase-3., Juraver-Geslin HA, Durand BC., Genesis. February 1, 2015; 53 (2): 203-24.          

Spatiotemporal integration of developmental cues in neural development., Borodinsky LN, Belgacem YH, Swapna I, Visina O, Balashova OA, Sequerra EB, Tu MK, Levin JB, Spencer KA, Castro PA, Hamilton AM, Shim S., Dev Neurobiol. April 1, 2015; 75 (4): 349-59.    

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan., Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY., Elife. July 9, 2015; 4                               

Cell-fate determination by ubiquitin-dependent regulation of translation., Werner A, Iwasaki S, McGourty CA, Medina-Ruiz S, Teerikorpi N, Fedrigo I, Ingolia NT, Rape M., Nature. September 24, 2015; 525 (7570): 523-7.                            

A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification., Rankin SA, Rankin SA, Han L, McCracken KW, Kenny AP, Anglin CT, Grigg EA, Crawford CM, Wells JM, Shannon JM, Zorn AM., Cell Rep. June 28, 2016; 16 (1): 66-78.                                              

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling., Huang P, Nedelcu D, Watanabe M, Jao C, Kim Y, Liu J, Salic A., Cell. August 25, 2016; 166 (5): 1176-1187.e14.

Genome evolution in the allotetraploid frog Xenopus laevis., Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS., Nature. October 20, 2016; 538 (7625): 336-343.                              

High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis., Michiue T, Yamamoto T, Yasuoka Y, Goto T, Ikeda T, Nagura K, Nakayama T, Taira M, Kinoshita T., Dev Biol. June 15, 2017; 426 (2): 270-290.                  

KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis., Lin H, Zhu X, Chen G, Song L, Gao L, Khand AA, Chen Y, Lin G, Tao Q, Tao Q., Development. October 15, 2017; 144 (20): 3674-3685.                          

Sonic hedgehog antagonists reduce size and alter patterning of the frog inner ear., Zarei S, Zarei K, Fritzsch B, Elliott KL., Dev Neurobiol. December 1, 2017; 77 (12): 1385-1400.                

Hyperinnervation improves Xenopus laevis limb regeneration., Mitogawa K, Makanae A, Satoh A., Dev Biol. January 15, 2018; 433 (2): 276-286.                    

Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney., Zhang B, Tran U, Wessely O., Development. March 22, 2018; 145 (6):                         

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