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Summary Expression Phenotypes Gene Literature (57) GO Terms (4) Nucleotides (229) Proteins (66) Interactants (136) Wiki
XB--489651

Papers associated with slc12a2



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Unexpected Effect of IL-1β on the Function of GABAA Receptors in Pediatric Focal Cortical Dysplasia., Alfano V, Romagnolo A, Mills JD, Cifelli P, Gaeta A, Morano A, Mühlebner A, Aronica E, Palma E, Ruffolo G., Brain Sci. June 19, 2022; 12 (6):


Human iPSC Modeling of Genetic Febrile Seizure Reveals Aberrant Molecular and Physiological Features Underlying an Impaired Neuronal Activity., Scalise S, Zannino C, Lucchino V, Lo Conte M, Scaramuzzino L, Cifelli P, D'Andrea T, Martinello K, Fucile S, Palma E, Gambardella A, Ruffolo G, Cuda G, Parrotta EI., Biomedicines. May 5, 2022; 10 (5):


Sequence analysis and function of mosquito aeCCC2 and Drosophila Ncc83 orthologs., Duong PC, McCabe TC, Riley GF, Holmes HL, Piermarini PM, Romero MF, Gillen CM., Insect Biochem Mol Biol. April 1, 2022; 143 103729.

SLC12A2 variants cause a neurodevelopmental disorder or cochleovestibular defect., McNeill A, Iovino E, Mansard L, Vache C, Baux D, Bedoukian E, Cox H, Dean J, Goudie D, Kumar A, Newbury-Ecob R, Fallerini C, Renieri A, Lopergolo D, Mari F, Blanchet C, Willems M, Roux AF, Pippucci T, Delpire E., Brain. August 1, 2020; 143 (8): 2380-2387.

WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration., Pacheco-Alvarez D, Carrillo-Pérez DL, Mercado A, Leyva-Ríos K, Moreno E, Hernández-Mercado E, Castañeda-Bueno M, Vázquez N, Gamba G., Am J Physiol Cell Physiol. August 1, 2020; 319 (2): C371-C380.

Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy., Brandt C, Seja P, Töllner K, Römermann K, Hampel P, Kalesse M, Kipper A, Feit PW, Lykke K, Toft-Bertelsen TL, Paavilainen P, Spoljaric I, Puskarjov M, MacAulay N, Kaila K, Löscher W., Neuropharmacology. December 1, 2018; 143 186-204.

A novel GABAergic dysfunction in human Dravet syndrome., Ruffolo G, Cifelli P, Roseti C, Thom M, van Vliet EA, Limatola C, Aronica E, Palma E., Epilepsia. November 1, 2018; 59 (11): 2106-2117.

Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells., Koumangoye R, Omer S, Delpire E., Am J Physiol Cell Physiol. August 1, 2018; 315 (2): C258-C276.

Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B., Hampel P, Römermann K, MacAulay N, Löscher W., Sci Rep. June 29, 2018; 8 (1): 9877.        

Cotransporter-mediated water transport underlying cerebrospinal fluid formation., Steffensen AB, Oernbo EK, Stoica A, Gerkau NJ, Barbuskaite D, Tritsaris K, Rose CR, MacAulay N., Nat Commun. June 4, 2018; 9 (1): 2167.              

Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions., Ruffolo G, Iyer A, Cifelli P, Roseti C, Mühlebner A, van Scheppingen J, Scholl T, Hainfellner JA, Feucht M, Krsek P, Zamecnik J, Jansen FE, Spliet WG, Limatola C, Aronica E, Palma E., Neurobiol Dis. November 1, 2016; 95 93-101.

Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells., Miraucourt LS, Tsui J, Gobert D, Desjardins JF, Schohl A, Sild M, Spratt P, Castonguay A, De Koninck Y, Marsh-Armstrong N, Wiseman PW, Ruthazer ES., Elife. August 8, 2016; 5                     

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters., Mercado A, de Los Heros P, Melo Z, Chávez-Canales M, Murillo-de-Ozores AR, Moreno E, Bazúa-Valenti S, Vázquez N, Hadchouel J, Gamba G., Am J Physiol Cell Physiol. July 1, 2016; 311 (1): C54-66.

The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A., Lykke K, Töllner K, Feit PW, Erker T, MacAulay N, Löscher W., Epilepsy Behav. June 1, 2016; 59 42-9.

An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system., Bestman JE, Huang LC, Lee-Osbourne J, Cheung P, Cline HT., Dev Biol. December 15, 2015; 408 (2): 269-91.                    

Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter., Lykke K, Töllner K, Römermann K, Feit PW, Erker T, MacAulay N, Löscher W., Br J Pharmacol. September 1, 2015; 172 (18): 4469-4480.

Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses., Larsen BR, Assentoft M, Cotrina ML, Hua SZ, Nedergaard M, Kaila K, Voipio J, MacAulay N., Glia. April 1, 2014; 62 (4): 608-22.

Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2., Park HJ, Curry JN, McCormick JA., Am J Physiol Renal Physiol. December 15, 2013; 305 (12): F1687-96.

Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene., Geng FS, Abbas L, Baxendale S, Holdsworth CJ, Swanson AG, Slanchev K, Hammerschmidt M, Topczewski J, Whitfield TT., Development. November 1, 2013; 140 (21): 4362-74.              

AqF026 is a pharmacologic agonist of the water channel aquaporin-1., Yool AJ, Morelle J, Cnops Y, Verbavatz JM, Campbell EM, Beckett EA, Booker GW, Flynn G, Devuyst O., J Am Soc Nephrol. June 1, 2013; 24 (7): 1045-52.

The GABA A receptor subunits heterologously expressed in Xenopus oocytes., Abdullah JM, Zhang J., Mini Rev Med Chem. April 1, 2013; 13 (5): 744-8.

A trafficking-deficient mutant of KCC3 reveals dominant-negative effects on K-Cl cotransport function., Ding J, Ponce-Coria J, Delpire E., PLoS One. January 1, 2013; 8 (4): e61112.                    

Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers., Ponce-Coria J, Gagnon KB, Delpire E., Am J Physiol Cell Physiol. December 1, 2012; 303 (11): C1198-205.

Cotransport of water by Na⁺-K⁺-2Cl⁻ cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2., Zeuthen T, Macaulay N., J Physiol. March 1, 2012; 590 (5): 1139-54.

WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family., Pacheco-Alvarez D, Vázquez N, Castañeda-Bueno M, de-Los-Heros P, Cortes-González C, Moreno E, Meade P, Bobadilla NA, Gamba G., Cell Physiol Biochem. January 1, 2012; 29 (1-2): 291-302.

Kinetics of hyperosmotically stimulated Na-K-2Cl cotransporter in Xenopus laevis oocytes., Delpire E, Gagnon KB., Am J Physiol Cell Physiol. November 1, 2011; 301 (5): C1074-85.

Similar effects of all WNK3 variants on SLC12 cotransporters., Cruz-Rangel S, Melo Z, Vázquez N, Meade P, Bobadilla NA, Pasantes-Morales H, Gamba G, Mercado A., Am J Physiol Cell Physiol. September 1, 2011; 301 (3): C601-8.

Anomalous levels of Cl- transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex., Conti L, Palma E, Roseti C, Lauro C, Cipriani R, de Groot M, Aronica E, Limatola C., Epilepsia. September 1, 2011; 52 (9): 1635-44.

WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., J Biol Chem. August 26, 2011; 286 (34): 30171-80.              

Housing and husbandry of Xenopus laevis affect the quality of oocytes for heterologous expression studies., Delpire E, Gagnon KB, Ledford JJ, Wallace JM., J Am Assoc Lab Anim Sci. January 1, 2011; 50 (1): 46-53.

Functional insights into the activation mechanism of Ste20-related kinases., Gagnon KB, Rios K, Delpire E., Cell Physiol Biochem. January 1, 2011; 28 (6): 1219-30.

WNK3 is a putative chloride-sensing kinase., Pacheco-Alvarez D, Gamba G., Cell Physiol Biochem. January 1, 2011; 28 (6): 1123-34.

Molecular determinants of hyperosmotically activated NKCC1-mediated K+/K+ exchange., Gagnon KB, Delpire E., J Physiol. September 15, 2010; 588 (Pt 18): 3385-96.

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity., Gagnon KB, Delpire E., Am J Physiol Cell Physiol. September 1, 2010; 299 (3): C614-20.

Multiple pathways for protein phosphatase 1 (PP1) regulation of Na-K-2Cl cotransporter (NKCC1) function: the N-terminal tail of the Na-K-2Cl cotransporter serves as a regulatory scaffold for Ste20-related proline/alanine-rich kinase (SPAK) AND PP1., Gagnon KB, Delpire E., J Biol Chem. May 7, 2010; 285 (19): 14115-21.

Functional expression of the Na-K-2Cl cotransporter NKCC2 in mammalian cells fails to confirm the dominant-negative effect of the AF splice variant., Hannemann A, Christie JK, Flatman PW., J Biol Chem. December 18, 2009; 284 (51): 35348-58.              

NKCC1 (SLC12a2) induces a secondary axis in Xenopus laevis embryos independently of its co-transporter function., Walters ZS, Haworth KE, Latinkic BV., J Physiol. February 1, 2009; 587 (3): 521-9.

Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransporters., Simard CF, Bergeron MJ, Frenette-Cotton R, Carpentier GA, Pelchat ME, Caron L, Isenring P., J Biol Chem. June 22, 2007; 282 (25): 18083-18093.

Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation., Gagnon KB, England R, Diehl L, Delpire E., Am J Physiol Cell Physiol. May 1, 2007; 292 (5): C1809-15.

WNK4 kinase is a negative regulator of K+-Cl- cotransporters., Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.

A single binding motif is required for SPAK activation of the Na-K-2Cl cotransporter., Gagnon KB, England R, Delpire E., Cell Physiol Biochem. January 1, 2007; 20 (1-4): 131-42.

The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion., Pacheco-Alvarez D, Cristóbal PS, Meade P, Moreno E, Vazquez N, Muñoz E, Díaz A, Juárez ME, Giménez I, Gamba G., J Biol Chem. September 29, 2006; 281 (39): 28755-63.

Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory., Palma E, Amici M, Sobrero F, Spinelli G, Di Angelantonio S, Ragozzino D, Mascia A, Scoppetta C, Esposito V, Miledi R, Eusebi F., Proc Natl Acad Sci U S A. May 30, 2006; 103 (22): 8465-8.

WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway., de Los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vázquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. February 7, 2006; 103 (6): 1976-81.

Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter., Gagnon KB, England R, Delpire E., Mol Cell Biol. January 1, 2006; 26 (2): 689-98.

Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4., Gagnon KB, England R, Delpire E., Am J Physiol Cell Physiol. January 1, 2006; 290 (1): C134-42.

Regulatory phosphorylation sites in the NH2 terminus of the renal Na-K-Cl cotransporter (NKCC2)., Giménez I, Forbush B., Am J Physiol Renal Physiol. December 1, 2005; 289 (6): F1341-5.

WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability., Kahle KT, Rinehart J, de Los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16783-8.

Novel insights regarding the operational characteristics and teleological purpose of the renal Na+-K+-Cl2 cotransporter (NKCC2s) splice variants., Brunet GM, Gagnon E, Simard CF, Daigle ND, Caron L, Noël M, Lefoll MH, Bergeron MJ, Isenring P., J Gen Physiol. October 1, 2005; 126 (4): 325-37.              

WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia., Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP., Proc Natl Acad Sci U S A. February 17, 2004; 101 (7): 2064-9.

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