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Summary Expression Phenotypes Gene Literature (24) GO Terms (15) Nucleotides (132) Proteins (47) Interactants (53) Wiki
XB-GENEPAGE-5757376

Papers associated with wnk3



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Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression., Ostrosky-Frid M, Chávez-Canales M, Zhang J, Andrukhova O, Argaiz ER, Lerdo-de-Tejada F, Murillo-de-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla NA, Vazquez N, Castañeda-Bueno M, Alessi DR, Gamba G., Am J Physiol Renal Physiol. May 1, 2021; 320 (5): F734-F747.                    

WNK3 and WNK4 exhibit opposite sensitivity with respect to cell volume and intracellular chloride concentration., Pacheco-Alvarez D, Carrillo-Pérez DL, Mercado A, Leyva-Ríos K, Moreno E, Hernández-Mercado E, Castañeda-Bueno M, Vázquez N, Gamba G., Am J Physiol Cell Physiol. August 1, 2020; 319 (2): C371-C380.

The receptor-like pseudokinase MRH1 interacts with the voltage-gated potassium channel AKT2., Sklodowski K, Riedelsberger J, Raddatz N, Riadi G, Caballero J, Chérel I, Schulze W, Graf A, Dreyer I., Sci Rep. March 16, 2017; 7 44611.            

WNK3 Kinase Enhances the Sodium Chloride Cotransporter Expression via an ERK 1/2 Signaling Pathway., Wang D, Zhang Y, Han J, Pan S, Xu N, Feng X, Zhuang Z, Caroti C, Zhuang J, Hoover RS, Gu D, Zeng Q, Cai H., Nephron. January 1, 2016; 133 (4): 287-95.

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4., Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J., Hypertension. November 1, 2014; 64 (5): 1047-53.

WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter., Lagnaz D, Arroyo JP, Chávez-Canales M, Vázquez N, Rizzo F, Spirlí A, Debonneville A, Staub O, Gamba G., Am J Physiol Renal Physiol. August 1, 2014; 307 (3): F275-86.

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling., Melo Z, de los Heros P, Cruz-Rangel S, Vázquez N, Bobadilla NA, Pasantes-Morales H, Alessi DR, Mercado A, Gamba G., J Biol Chem. November 1, 2013; 288 (44): 31468-76.            

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo., Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S., Biol Open. February 15, 2012; 1 (2): 120-7.              

WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family., Pacheco-Alvarez D, Vázquez N, Castañeda-Bueno M, de-Los-Heros P, Cortes-González C, Moreno E, Meade P, Bobadilla NA, Gamba G., Cell Physiol Biochem. January 1, 2012; 29 (1-2): 291-302.

Similar effects of all WNK3 variants on SLC12 cotransporters., Cruz-Rangel S, Melo Z, Vázquez N, Meade P, Bobadilla NA, Pasantes-Morales H, Gamba G, Mercado A., Am J Physiol Cell Physiol. September 1, 2011; 301 (3): C601-8.

WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters., Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP., J Biol Chem. August 26, 2011; 286 (34): 30171-80.              

Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters., Acuña R, Martínez-de-la-Maza L, Ponce-Coria J, Vázquez N, Ortal-Vite P, Pacheco-Alvarez D, Bobadilla NA, Gamba G., J Hypertens. March 1, 2011; 29 (3): 475-83.

WNK3 is a putative chloride-sensing kinase., Pacheco-Alvarez D, Gamba G., Cell Physiol Biochem. January 1, 2011; 28 (6): 1123-34.

Renal and brain isoforms of WNK3 have opposite effects on NCCT expression., Glover M, Zuber AM, O'Shaughnessy KM., J Am Soc Nephrol. June 1, 2009; 20 (6): 1314-22.

WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway., Zhang W, Na T, Peng JB., Am J Physiol Renal Physiol. November 1, 2008; 295 (5): F1472-84.

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter., San-Cristobal P, Ponce-Coria J, Vázquez N, Bobadilla NA, Gamba G., Am J Physiol Renal Physiol. October 1, 2008; 295 (4): F1199-206.

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases., Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. June 17, 2008; 105 (24): 8458-63.

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex., Yang CL, Zhu X, Ellison DH., J Clin Invest. November 1, 2007; 117 (11): 3403-11.

SLC26A9 is a Cl(-) channel regulated by the WNK kinases., Dorwart MR, Shcheynikov N, Wang Y, Stippec S, Muallem S., J Physiol. October 1, 2007; 584 (Pt 1): 333-45.

WNK4 kinase is a negative regulator of K+-Cl- cotransporters., Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.

WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)., Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC., J Physiol. March 1, 2006; 571 (Pt 2): 275-86.

WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway., de Los Heros P, Kahle KT, Rinehart J, Bobadilla NA, Vázquez N, San Cristobal P, Mount DB, Lifton RP, Hebert SC, Gamba G., Proc Natl Acad Sci U S A. February 7, 2006; 103 (6): 1976-81.

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis., Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16777-82.

WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability., Kahle KT, Rinehart J, de Los Heros P, Louvi A, Meade P, Vazquez N, Hebert SC, Gamba G, Gimenez I, Lifton RP., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16783-8.

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