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Summary Expression Phenotypes Gene Literature (31) GO Terms (7) Nucleotides (113) Proteins (57) Interactants (99) Wiki
XB--5817034

Papers associated with kcnq4



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KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness., Kubisch C, Schroeder BC, Friedrich T, Lütjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch TJ., Cell. February 5, 1999; 96 (3): 437-46.

A constitutively open potassium channel formed by KCNQ1 and KCNE3., Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, Jentsch TJ., Nature. January 13, 2000; 403 (6766): 196-9.

KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology., Søgaard R, Ljungstrøm T, Pedersen KA, Olesen SP, Jensen BS., Am J Physiol Cell Physiol. April 1, 2001; 280 (4): C859-66.

Dual-function vector for protein expression in both mammalian cells and Xenopus laevis oocytes., Jespersen T, Grunnet M, Angelo K, Klaerke DA, Olesen SP., Biotechniques. March 1, 2002; 32 (3): 536-8, 540.

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly., Schwake M, Jentsch TJ, Friedrich T., EMBO Rep. January 1, 2003; 4 (1): 76-81.

KCNQ1 channels sense small changes in cell volume., Grunnet M, Jespersen T, MacAulay N, Jørgensen NK, Schmitt N, Pongs O, Olesen SP, Klaerke DA., J Physiol. June 1, 2003; 549 (Pt 2): 419-27.

Functional coupling between heterologously expressed dopamine D(2) receptors and KCNQ channels., Ljungstrom T, Grunnet M, Jensen BS, Olesen SP., Pflugers Arch. September 1, 2003; 446 (6): 684-94.

The therapeutic potential of neuronal KCNQ channel modulators., Gribkoff VK., Expert Opin Ther Targets. December 1, 2003; 7 (6): 737-48.

Linopirdine blocks alpha9alpha10-containing nicotinic cholinergic receptors of cochlear hair cells., Gomez-Casati ME, Katz E, Glowatzki E, Lioudyno MI, Fuchs P, Elgoyhen AB., J Assoc Res Otolaryngol. September 1, 2004; 5 (3): 261-9.

Regulation of KCNQ4 potassium channel prepulse dependence and current amplitude by SGK1 in Xenopus oocytes., Seebohm G, Strutz-Seebohm N, Baltaev R, Korniychuk G, Knirsch M, Engel J, Lang F., Cell Physiol Biochem. January 1, 2005; 16 (4-6): 255-62.

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine., Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J, Schwake M., J Neurosci. May 18, 2005; 25 (20): 5051-60.

Functional coassembly of KCNQ4 with KCNE-beta- subunits in Xenopus oocytes., Strutz-Seebohm N, Seebohm G, Fedorenko O, Baltaev R, Engel J, Knirsch M, Lang F., Cell Physiol Biochem. January 1, 2006; 18 (1-3): 57-66.

Studies of the effect of ionomycin on the KCNQ4 channel expressed in Xenopus oocytes., Su CC, Li SY, Yang JJ, Su MC, Lin MJ., Biochem Biophys Res Commun. September 15, 2006; 348 (1): 295-300.

The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes., Panaghie G, Abbott GW., J Gen Physiol. February 1, 2007; 129 (2): 121-33.                      

Inactivation as a new regulatory mechanism for neuronal Kv7 channels., Jensen HS, Grunnet M, Olesen SP., Biophys J. April 15, 2007; 92 (8): 2747-56.

A novel KCNQ4 pore-region mutation (p.G296S) causes deafness by impairing cell-surface channel expression., Mencía A, González-Nieto D, Modamio-Høybjør S, Etxeberría A, Aránguez G, Salvador N, Del Castillo I, Villarroel A, Moreno F, Barrio L, Moreno-Pelayo MA., Hum Genet. February 1, 2008; 123 (1): 41-53.

Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks., Nakajo K, Kubo Y., J Physiol. June 15, 2008; 586 (12): 2827-40.

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents., Yeung S, Schwake M, Pucovský V, Greenwood Ia., Br J Pharmacol. September 1, 2008; 155 (1): 62-72.

Gating currents from neuronal K(V)7.4 channels: general features and correlation with the ionic conductance., Miceli F, Cilio MR, Taglialatela M, Bezanilla F., Channels (Austin). January 1, 2009; 3 (4): 274-83.

Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes., Su TR, Chen CH, Huang SJ, Lee CY, Lee CY, Su MC, Chen GH, Li SY, Yang JJ, Lin MJ., Acta Pharmacol Sin. September 1, 2009; 30 (9): 1220-6.        

The acrylamide (S)-2 as a positive and negative modulator of Kv7 channels expressed in Xenopus laevis oocytes., Blom SM, Schmitt N, Jensen HS., PLoS One. December 11, 2009; 4 (12): e8251.                  

Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1., Aidery P, Kisselbach J, Schweizer PA, Becker R, Katus HA, Thomas D., Gene. December 10, 2012; 511 (1): 26-33.        

Downregulation of KCNQ4 by Janus kinase 2., Hosseinzadeh Z, Sopjani M, Pakladok T, Bhavsar SK, Lang F., J Membr Biol. April 1, 2013; 246 (4): 335-41.

Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders., Gilling M, Rasmussen HB, Calloe K, Sequeira AF, Baretto M, Oliveira G, Almeida J, Lauritsen MB, Ullmann R, Boonen SE, Brondum-Nielsen K, Kalscheuer VM, Tümer Z, Vicente AM, Schmitt N, Tommerup N., Front Genet. April 16, 2013; 4 54.                  

RNA-Seq and microarray analysis of the Xenopus inner ear transcriptome discloses orthologous OMIM(®) genes for hereditary disorders of hearing and balance., Ramírez-Gordillo D, Powers TR, van Velkinburgh JC, Trujillo-Provencio C, Schilkey F, Serrano EE., BMC Res Notes. November 18, 2015; 8 691.      

Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4., Abbott GW., FASEB J. August 1, 2016; 30 (8): 2959-69.

4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv 7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries., Khammy MM, Kim S, Bentzen BH, Lee S, Choi I, Aalkjaer C, Jepps TA., Br J Pharmacol. February 1, 2018; 175 (3): 501-516.

Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels., Manville RW, Abbott GW., Mol Pharmacol. October 1, 2018; 94 (4): 1155-1163.

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner., Manville RW, Abbott GW., Commun Biol. January 1, 2019; 2 401.                    

The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator., Redford KE, Abbott GW., Commun Biol. July 8, 2020; 3 (1): 356.

The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels., Manville RW, Abbott GW., Cell Physiol Biochem. July 28, 2021; 55 (S3): 157-170.

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