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Summary Expression Phenotypes Gene Literature (68) GO Terms (7) Nucleotides (69) Proteins (29) Interactants (152) Wiki

Papers associated with scn5a

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1 paper(s) referencing morpholinos

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Distinct functional properties of two electrogenic isoforms of the SLC34 Na-Pi cotransporter., Mizutani N, Okochi Y, Okamura Y., Physiol Rep. January 1, 2019; 7 (14): e14156.              

Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation., Zhu W, Mazzanti A, Voelker TL, Hou P, Moreno JD, Angsutararux P, Naegle KM, Priori SG, Silva JR., Circ Res. January 1, 2019; 124 (4): 539-552.

Genomic Takeover by Transposable Elements in the Strawberry Poison Frog., Rogers RL, Zhou L, Chu C, Márquez R, Corl A, Linderoth T, Freeborn L, MacManes MD, Xiong Z, Zheng J, Guo C, Xun X, Kronforst MR, Summers K, Wu Y, Yang H, Richards-Zawacki CL, Zhang G, Nielsen R., Mol Biol Evol. January 1, 2018; 35 (12): 2913-2927.              

Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy., Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y, Arandel L, Jollet A, Thibault C, Philipps M, Vicaire S, Jost B, Udd B, Day JW, Duboc D, Wahbi K, Matsumura T, Fujimura H, Mochizuki H, Deryckere F, Kimura T, Nukina N, Ishiura S, Lacroix V, Campan-Fournier A, Navratil V, Chautard E, Auboeuf D, Horie M, Imoto K, Lee KY, Swanson MS, de Munain AL, Inada S, Itoh H, Nakazawa K, Ashihara T, Wang E, Zimmer T, Furling D, Takahashi MP, Charlet-Berguerand N., Nat Commun. April 11, 2016; 7 11067.              

Differential effects of the recombinant toxin PnTx4(5-5) from the spider Phoneutria nigriventer on mammalian and insect sodium channels., Paiva AL, Matavel A, Peigneur S, Cordeiro MN, Tytgat J, Diniz MR, de Lima ME., Biochimie. February 1, 2016; 121 326-35.

Electrophysiological characterization of a large set of novel variants in the SCN5A-gene: identification of novel LQTS3 and BrS mutations., Ortiz-Bonnin B, Rinné S, Moss R, Streit AK, Scharf M, Richter K, Stöber A, Pfeufer A, Seemann G, Kääb S, Beckmann BM, Decher N., Pflugers Arch. January 1, 2016; 468 (8): 1375-87.

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD., Sci Rep. September 21, 2015; 5 14763.                                

A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms., Peigneur S, Cologna CT, Cremonez CM, Mille BG, Pucca MB, Cuypers E, Arantes EC, Tytgat J., Neuropharmacology. August 1, 2015; 95 269-77.

The alternative splicing regulator Tra2b is required for somitogenesis and regulates splicing of an inhibitory Wnt11b isoform., Dichmann DS, Walentek P, Harland RM., Cell Rep. February 3, 2015; 10 (4): 527-36.                    

Voltage-dependent blockade by bupivacaine of cardiac sodium channels expressed in Xenopus oocytes., Zhang H, Ji H, Liu Z, Ji Y, You X, Ding G, Cheng Z., Neurosci Bull. August 1, 2014; 30 (4): 697-710.

Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder., Friedrich C, Rinné S, Zumhagen S, Kiper AK, Silbernagel N, Netter MF, Stallmeyer B, Schulze-Bahr E, Decher N., EMBO Mol Med. July 1, 2014; 6 (7): 937-51.              

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels., Klint JK, Berecki G, Durek T, Mobli M, Knapp O, King GF, Adams DJ, Alewood PF, Rash LD., Biochem Pharmacol. May 15, 2014; 89 (2): 276-86.

Analysis of the interaction of tarantula toxin Jingzhaotoxin-III (β-TRTX-Cj1α) with the voltage sensor of Kv2.1 uncovers the molecular basis for cross-activities on Kv2.1 and Nav1.5 channels., Tao H, Chen JJ, Xiao YC, Wu YY, Su HB, Li D, Wang HY, Deng MC, Wang MC, Liu ZH, Liang SP., Biochemistry. October 22, 2013; 52 (42): 7439-48.

Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel., Jones DK, Claydon TW, Ruben PC., Biophys J. July 2, 2013; 105 (1): 101-7.

Cardiac channelopathy causing sudden death as revealed by molecular autopsy., Kauferstein S, Kiehne N, Peigneur S, Tytgat J, Bratzke H., Int J Legal Med. January 1, 2013; 127 (1): 145-51.

Characterization of N-terminally mutated cardiac Na(+) channels associated with long QT syndrome 3 and Brugada syndrome., Gütter C, Benndorf K, Zimmer T., Front Physiol. January 1, 2013; 4 153.            

Coexisting mutations/polymorphisms of the long QT syndrome genes in patients with repaired Tetralogy of Fallot are associated with the risks of life-threatening events., Chiu SN, Wu MH, Su MJ, Wang JK, Lin MT, Chang CC, Hsu HW, Shen CT, Thériault O, Chahine M., Hum Genet. August 1, 2012; 131 (8): 1295-304.

18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels., Du YM, Xia CK, Zhao N, Dong Q, Lei M, Xia JH., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.            

JZTX-XIII, a Kv channel gating modifier toxin from Chinese tarantula Chilobrachys jingzhao., Yuan C, Liu Z, Hu W, Gao T, Liang S., Toxicon. February 1, 2012; 59 (2): 265-71.

Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis., Pai VP, Aw S, Shomrat T, Lemire JM, Levin M., Development. January 1, 2012; 139 (2): 313-23.                

A proton leak current through the cardiac sodium channel is linked to mixed arrhythmia and the dilated cardiomyopathy phenotype., Gosselin-Badaroudine P, Keller DI, Huang H, Pouliot V, Chatelier A, Osswald S, Brink M, Chahine M., PLoS One. January 1, 2012; 7 (5): e38331.          

Extracellular proton modulation of the cardiac voltage-gated sodium channel, Nav1.5., Jones DK, Peters CH, Tolhurst SA, Claydon TW, Ruben PC., Biophys J. November 2, 2011; 101 (9): 2147-56.

Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics., Arcisio-Miranda M, Muroi Y, Chowdhury S, Chanda B., J Gen Physiol. November 1, 2010; 136 (5): 541-54.                

Induction of vertebrate regeneration by a transient sodium current., Tseng AS, Beane WS, Lemire JM, Masi A, Levin M., J Neurosci. September 29, 2010; 30 (39): 13192-200.                    

Pharmacological modulation of brain Nav1.2 and cardiac Nav1.5 subtypes by the local anesthetic ropivacaine., Cheng HW, Yang HT, Zhou JJ, Ji YH, Zhu HY., Neurosci Bull. August 1, 2010; 26 (4): 289-96.

Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome., Gui J, Wang T, Jones RP, Trump D, Zimmer T, Lei M., PLoS One. June 7, 2010; 5 (6): e10985.              

Blocking effect of methylflavonolamine on human Na(V)1.5 channels expressed in Xenopus laevis oocytes and on sodium currents in rabbit ventricular myocytes., Fan XR, Ma JH, Zhang PH, Xing JL., Acta Pharmacol Sin. March 1, 2010; 31 (3): 297-306.                  

Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel., Zhang Y, Wang T, Ma A, Zhou X, Gui J, Wan H, Shi R, Huang C, Grace AA, Huang CL, Trump D, Zhang H, Zimmer T, Lei M., Acta Physiol (Oxf). December 1, 2008; 194 (4): 311-23.            

Cardiac ion channel gene mutations in sudden infant death syndrome., Otagiri T, Kijima K, Osawa M, Ishii K, Makita N, Matoba R, Umetsu K, Hayasaka K., Pediatr Res. November 1, 2008; 64 (5): 482-7.

An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels., Ma Z, Wong KY, Horrigan FT., J Gen Physiol. May 1, 2008; 131 (5): 483-502.                      

Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel., Surber R, Hensellek S, Prochnau D, Werner GS, Benndorf K, Figulla HR, Zimmer T., Cardiovasc Res. March 1, 2008; 77 (4): 740-8.

Cardiac sodium channel gene variants and sudden cardiac death in women., Albert CM, Nam EG, Rimm EB, Jin HW, Hajjar RJ, Hunter DJ, MacRae CA, Ellinor PT., Circulation. January 1, 2008; 117 (1): 16-23.

Cardiac sodium channel mutation in atrial fibrillation., Ellinor PT, Nam EG, Shea MA, Milan DJ, Ruskin JN, MacRae CA., Heart Rhythm. January 1, 2008; 5 (1): 99-105.

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels., Zhang MM, Green BR, Catlin P, Fiedler B, Azam L, Chadwick A, Terlau H, McArthur JR, French RJ, Gulyas J, Rivier JE, Smith BJ, Norton RS, Olivera BM, Yoshikami D, Bulaj G., J Biol Chem. October 19, 2007; 282 (42): 30699-706.

Solution structure of Jingzhaotoxin-III, a peptide toxin inhibiting both Nav1.5 and Kv2.1 channels., Liao Z, Yuan C, Peng K, Xiao Y, Liang S., Toxicon. July 1, 2007; 50 (1): 135-43.

The intracellular domain of the beta 2 subunit modulates the gating of cardiac Na v 1.5 channels., Zimmer T, Benndorf K., Biophys J. June 1, 2007; 92 (11): 3885-92.

Differential sensitivity of rat voltage-sensitive sodium channel isoforms to pyrazoline-type insecticides., Silver KS, Soderlund DM., Toxicol Appl Pharmacol. July 15, 2006; 214 (2): 209-17.

GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function., Membrez M, Hummler E, Beermann F, Haefliger JA, Savioz R, Pedrazzini T, Thorens B., Mol Cell Biol. June 1, 2006; 26 (11): 4268-76.

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes., Bosmans F, Rash L, Zhu S, Diochot S, Lazdunski M, Escoubas P, Tytgat J., Mol Pharmacol. February 1, 2006; 69 (2): 419-29.

OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels., Jalali A, Bosmans F, Amininasab M, Clynen E, Cuypers E, Zaremirakabadi A, Sarbolouki MN, Schoofs L, Vatanpour H, Tytgat J., FEBS Lett. August 1, 2005; 579 (19): 4181-6.

Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1., Liu LH, Bosmans F, Maertens C, Zhu RH, Wang DC, Tytgat J., FASEB J. April 1, 2005; 19 (6): 594-6.

Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome., Zehelein J, Thomas D, Khalil M, Wimmer AB, Koenen M, Licka M, Wu K, Kiehn J, Brockmeier K, Kreye VA, Karle CA, Katus HA, Ulmer HE, Schoels W., Biochim Biophys Acta. November 5, 2004; 1690 (3): 185-92.

State-dependent trapping of flecainide in the cardiac sodium channel., Ramos E, O'leary ME., J Physiol. October 1, 2004; 560 (Pt 1): 37-49.

Occurrence of a tetrodotoxin-sensitive calcium current in rat ventricular myocytes after long-term myocardial infarction., Alvarez JL, Salinas-Stefanon E, Orta G, Ferrer T, Talavera K, Galán L, Vassort G., Cardiovasc Res. September 1, 2004; 63 (4): 653-61.

Compound mutations: a common cause of severe long-QT syndrome., Westenskow P, Splawski I, Timothy KW, Keating MT, Sanguinetti MC., Circulation. April 20, 2004; 109 (15): 1834-41.

A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill., Takehara N, Makita N, Kawabe J, Sato N, Kawamura Y, Kitabatake A, Kikuchi K., J Intern Med. January 1, 2004; 255 (1): 137-42.

Closing and inactivation potentiate the cocaethylene inhibition of cardiac sodium channels by distinct mechanisms., O'Leary ME, Digregorio M, Chahine M., Mol Pharmacol. December 1, 2003; 64 (6): 1575-85.

Inhibition of cardiac sodium currents by toluene exposure., Cruz SL, Orta-Salazar G, Gauthereau MY, Millan-Perez Peña L, Salinas-Stefanón EM., Br J Pharmacol. October 1, 2003; 140 (4): 653-60.

Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects., Herfst LJ, Potet F, Bezzina CR, Groenewegen WA, Le Marec H, Hoorntje TM, Demolombe S, Baró I, Escande D, Jongsma HJ, Wilde AA, Rook MB., J Mol Cell Cardiol. May 1, 2003; 35 (5): 549-57.

Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A., Boehmer C, Wilhelm V, Palmada M, Wallisch S, Henke G, Brinkmeier H, Cohen P, Pieske B, Lang F., Cardiovasc Res. March 15, 2003; 57 (4): 1079-84.

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