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Summary Expression Phenotypes Gene Literature (111) GO Terms (7) Nucleotides (38) Proteins (23) Interactants (73) Wiki

Papers associated with purinergic receptor P2X, ligand gated ion channel, 2

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Cross-Talk between P2X and NMDA Receptors., Rodriguez L, Yi C, Chu C, Duriez Q, Watanabe S, Ryu M, Reyes B, Asatryan L, Boué-Grabot E, Davies D., Int J Mol Sci. September 29, 2020; 21 (19):                           

Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing., Khoo KK, Galleano I, Gasparri F, Wieneke R, Harms H, Poulsen MH, Chua HC, Wulf M, Tampé R, Pless SA., Nat Commun. January 1, 2020; 11 (1): 2284.            

Comparative Embryonic Spatio-Temporal Expression Profile Map of the Xenopus P2X Receptor Family., Blanchard C, Boué-Grabot E, Massé K., Front Cell Neurosci. January 1, 2019; 13 340.                    

Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors., Obrecht AS, Urban N, Schaefer M, Röse A, Kless A, Meents JE, Lampert A, Abdelrahman A, Müller CE, Schmalzing G, Hausmann R., Neuropharmacology. January 1, 2019; 158 107749.

Evidence for an effect of receptor density on ligand occupancy and agonist EC50., Jarvis GE, Thompson AJ., Sci Rep. January 1, 2019; 9 (1): 19111.            

Bile acids are potent inhibitors of rat P2X2 receptors., Schmidt A, Joussen S, Hausmann R, Gründer S, Wiemuth D., Purinergic Signal. January 1, 2019; 15 (2): 213-221.

Molecular determinants for agonist recognition and discrimination in P2X2 receptors., Gasparri F, Wengel J, Grutter T, Pless SA., J Gen Physiol. January 1, 2019; 151 (7): 898-911.                    

Physiological Concentrations of Zinc Have Dual Effects on P2X Myenteric Receptors of Guinea Pig., Méndez-Barredo LH, Rodríguez-Meléndez JG, Gómez-Coronado KS, Guerrero-Alba R, Valdez-Morales EE, Espinosa-Luna R, Barajas-Espinosa A, Barajas-López C., Cell Mol Neurobiol. October 1, 2018; 38 (7): 1439-1449.

Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel., Rokic MB, Castro P, Leiva-Salcedo E, Tomic M, Stojilkovic SS, Coddou C., Int J Mol Sci. April 11, 2018; 19 (4):                     

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372., Coddou C, Sandoval R, Castro P, Lazcano P, Hevia MJ, Rokic M, Hall B, Terse A, Gonzalez-Billault C, Kulkarni AB, Stojilkovic SS, Utreras E., Pain. November 1, 2017; 158 (11): 2155-2168.

Interaction of Purinergic P2X4 and P2X7 Receptor Subunits., Schneider M, Prudic K, Pippel A, Klapperstück M, Braam U, Müller CE, Schmalzing G, Markwardt F., Front Pharmacol. January 1, 2017; 8 860.                        

Two P2X1 receptor transcripts able to form functional channels are present in most human monocytes., López-López C, Jaramillo-Polanco J, Portales-Pérez DP, Gómez-Coronado KS, Rodríguez-Meléndez JG, Cortés-García JD, Espinosa-Luna R, Montaño LM, Barajas-López C., Eur J Pharmacol. December 15, 2016; 793 82-88.

A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels., Emerit MB, Baranowski C, Diaz J, Martinez A, Areias J, Alterio J, Masson J, Boué-Grabot E, Darmon M., J Neurosci. February 3, 2016; 36 (5): 1456-70.  

Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus., Rodrigues RJ, Almeida T, Díaz-Hernández M, Marques JM, Franco R, Solsona C, Miras-Portugal MT, Ciruela F, Cunha RA., Neuropharmacology. January 1, 2016; 105 241-257.

Heteromeric channels with different phenotypes are generated when coexpressing two P2X2 receptor isoforms., Jaramillo-Polanco J, Liñán-Rico A, Espinosa-Luna R, Jiménez-Bremont JF, Montaño LM, Miranda-Morales M, Barajas-López C., Biochem Biophys Res Commun. January 1, 2016; 477 (1): 54-61.

P2X-mediated AMPA receptor internalization and synaptic depression is controlled by two CaMKII phosphorylation sites on GluA1 in hippocampal neurons., Pougnet JT, Compans B, Martinez A, Choquet D, Hosy E, Boué-Grabot E., Sci Rep. January 1, 2016; 6 31836.            

Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors., Kowalski M, Hausmann R, Schmid J, Dopychai A, Stephan G, Tang Y, Schmalzing G, Illes P, Rubini P., Neuropharmacology. December 1, 2015; 99 115-30.

Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels., Allsopp RC, Evans RJ., J Biol Chem. June 5, 2015; 290 (23): 14556-66.                

Voltage- and ATP-dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore., Keceli B, Kubo Y., J Physiol. November 1, 2014; 592 (21): 4657-76.

Subtype-specific mechanisms for functional interaction between α6β4* nicotinic acetylcholine receptors and P2X receptors., Limapichat W, Dougherty DA, Lester HA., Mol Pharmacol. September 1, 2014; 86 (3): 263-74.

Signal transmission within the P2X2 trimeric receptor., Keceli B, Kubo Y., J Gen Physiol. June 1, 2014; 143 (6): 761-82.                      

Potent and long-lasting inhibition of human P2X2 receptors by copper., Punthambaker S, Hume RI., Neuropharmacology. February 1, 2014; 77 167-76.

P2X receptor chimeras highlight roles of the amino terminus to partial agonist efficacy, the carboxyl terminus to recovery from desensitization, and independent regulation of channel transitions., Allsopp RC, Farmer LK, Fryatt AG, Evans RJ., J Biol Chem. July 19, 2013; 288 (29): 21412-21421.                

Salt bridge switching from Arg290/Glu167 to Arg290/ATP promotes the closed-to-open transition of the P2X2 receptor., Hausmann R, Günther J, Kless A, Kuhlmann D, Kassack MU, Bahrenberg G, Markwardt F, Schmalzing G., Mol Pharmacol. January 1, 2013; 83 (1): 73-84.

Allosteric nature of P2X receptor activation probed by photoaffinity labelling., Bhargava Y, Rettinger J, Mourot A., Br J Pharmacol. November 1, 2012; 167 (6): 1301-10.

Retention of a new-defined intron changes pharmacology and kinetics of the full-length P2X2 receptor found in myenteric neurons of the guinea pig., Liñan-Rico A, Jaramillo-Polanco J, Espinosa-Luna R, Jiménez-Bremont JF, Liñan-Rico L, Montaño LM, Barajas-López C., Neuropharmacology. September 1, 2012; 63 (3): 394-404.

ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors., Hausmann R, Bodnar M, Woltersdorf R, Wang H, Fuchs M, Messemer N, Qin Y, Günther J, Riedel T, Grohmann M, Nieber K, Schmalzing G, Rubini P, Illes P., J Biol Chem. April 20, 2012; 287 (17): 13930-43.

P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties., Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F., J Neurosci. March 21, 2012; 32 (12): 4284-96.

Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop., El-Ajouz S, Ray D, Allsopp RC, Evans RJ., Br J Pharmacol. January 1, 2012; 165 (2): 390-400.          

Covalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP., Dellal SS, Hume RI., PLoS One. January 1, 2012; 7 (10): e47147.                    

Cloning and characterization of a P2X receptor expressed in the central nervous system of Lymnaea stagnalis., Bavan S, Straub VA, Webb TE, Ennion SJ., PLoS One. January 1, 2012; 7 (11): e50487.                

The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels., Allsopp RC, Evans RJ., J Biol Chem. December 30, 2011; 286 (52): 44691-701.            

Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action., Marques-da-Silva C, Chaves MM, Castro NG, Coutinho-Silva R, Guimaraes MZ., Br J Pharmacol. July 1, 2011; 163 (5): 912-26.

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor., Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, Müller CE., J Med Chem. February 10, 2011; 54 (3): 817-30.

Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes., Bongartz EV, Rettinger J, Hausmann R., Purinergic Signal. December 1, 2010; 6 (4): 393-403.

Selective potentiation of homomeric P2X2 ionotropic ATP receptors by a fast non-genomic action of progesterone., De Roo M, Boué-Grabot E, Schlichter R., Neuropharmacology. March 1, 2010; 58 (3): 569-77.

Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating., Keceli B, Kubo Y., J Physiol. December 15, 2009; 587 (Pt 24): 5801-18.

Dynamic aspects of functional regulation of the ATP receptor channel P2X2., Kubo Y, Fujiwara Y, Keceli B, Nakajo K., J Physiol. November 15, 2009; 587 (Pt 22): 5317-24.

Reactive oxygen species potentiate the P2X2 receptor activity through intracellular Cys430., Coddou C, Codocedo JF, Li S, Lillo JG, Acuña-Castillo C, Bull P, Stojilkovic SS, Huidobro-Toro JP., J Neurosci. September 30, 2009; 29 (39): 12284-91.

Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis., Roberts JA, Valente M, Allsopp RC, Watt D, Evans RJ., J Neurochem. May 1, 2009; 109 (4): 1042-52.              

A P2X receptor from the tardigrade species Hypsibius dujardini with fast kinetics and sensitivity to zinc and copper., Bavan S, Straub VA, Blaxter ML, Ennion SJ., BMC Evol Biol. January 20, 2009; 9 17.            

Voltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel., Fujiwara Y, Keceli B, Nakajo K, Kubo Y., J Gen Physiol. January 1, 2009; 133 (1): 93-109.                      

Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors., Mo G, Bernier LP, Zhao Q, Chabot-Doré AJ, Ase AR, Logothetis D, Cao CQ, Séguéla P., Mol Pain. January 1, 2009; 5 47.            

Opposite effects of zinc on human and rat P2X2 receptors., Tittle RK, Hume RI., J Neurosci. October 29, 2008; 28 (44): 11131-40.

Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors., Asatryan L, Popova M, Woodward JJ, King BF, Alkana RL, Davies DL., Neuropharmacology. October 1, 2008; 55 (5): 835-43.

Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors., Roberts JA, Digby HR, Kara M, El Ajouz S, Sutcliffe MJ, Evans RJ., J Biol Chem. July 18, 2008; 283 (29): 20126-36.                

Contribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X2 receptors., Friday SC, Hume RI., J Neurochem. May 1, 2008; 105 (4): 1264-75.

Lack of evidence for direct phosphorylation of recombinantly expressed P2X(2) and P2X (3) receptors by protein kinase C., Franklin C, Braam U, Eisele T, Schmalzing G, Hausmann R., Purinergic Signal. September 1, 2007; 3 (4): 377-88.              

A histidine scan to probe the flexibility of the rat P2X2 receptor zinc-binding site., Tittle RK, Power JM, Hume RI., J Biol Chem. July 6, 2007; 282 (27): 19526-33.

Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides., Fujiwara Y, Kubo Y., J Physiol. October 1, 2006; 576 (Pt 1): 135-49.

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