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Summary Expression Phenotypes Gene Literature (54) GO Terms (1) Nucleotides (242) Proteins (106) Interactants (150) Wiki
XB-GENEPAGE-6259083

Papers associated with numa1



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A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel., Auld VJ, Goldin AL, Krafte DS, Catterall WA, Lester HA, Davidson N, Dunn RJ., Proc Natl Acad Sci U S A. January 1, 1990; 87 (1): 323-7.

Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons., Zhang JF, Randall AD, Ellinor PT, Horne WA, Sather WA, Tanabe T, Schwarz TL, Tsien RW., Neuropharmacology. November 1, 1993; 32 (11): 1075-88.

Conductance mutations of the nicotinic acetylcholine receptor do not act by a simple electrostatic mechanism., Kienker P, Tomaselli G, Jurman M, Yellen G., Biophys J. February 1, 1994; 66 (2 Pt 1): 325-34.

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole., Gaglio T, Saredi A, Bingham JB, Hasbani MJ, Gill SR, Schroer TA, Compton DA., J Cell Biol. October 1, 1996; 135 (2): 399-414.

Two major autoantigen-antibody systems of the mitotic spindle apparatus., Andrade LE, Chan EK, Peebles CL, Tan EM., Arthritis Rheum. October 1, 1996; 39 (10): 1643-53.

The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus., Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB., Arthritis Rheum. October 1, 1996; 39 (10): 1635-42.

A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly., Merdes A, Ramyar K, Vechio JD, Cleveland DW., Cell. November 1, 1996; 87 (3): 447-58.

Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes., Gaglio T, Dionne MA, Compton DA., J Cell Biol. September 8, 1997; 138 (5): 1055-66.              

Pulse treatment of interphasic HeLa cells with nanomolar doses of docetaxel affects centrosome organization and leads to catastrophic exit of mitosis., Paoletti A, Giocanti N, Favaudon V, Bornens M., J Cell Sci. October 1, 1997; 110 ( Pt 19) 2403-15.

The role of NuMA in the interphase nucleus., Merdes A, Cleveland DW., J Cell Sci. January 1, 1998; 111 ( Pt 1) 71-9.

Expanding the role of HsEg5 within the mitotic and post-mitotic phases of the cell cycle., Whitehead CM, Rattner JB., J Cell Sci. September 1, 1998; 111 ( Pt 17) 2551-61.

NuMA is a component of an insoluble matrix at mitotic spindle poles., Dionne MA, Howard L, Compton DA., Cell Motil Cytoskeleton. January 1, 1999; 42 (3): 189-203.

Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts., Zhang C, Hughes M, Clarke PR., J Cell Sci. July 1, 1999; 112 ( Pt 14) 2453-61.

Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly., Kahana JA, Cleveland DW., J Cell Biol. September 20, 1999; 146 (6): 1205-10.    

The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle., Mountain V, Simerly C, Howard L, Ando A, Schatten G, Compton DA., J Cell Biol. October 18, 1999; 147 (2): 351-66.                    

A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract., Steen RL, Cubizolles F, Le Guellec K, Collas P., J Cell Biol. May 1, 2000; 149 (3): 531-6.          

NuMA: a nuclear protein involved in mitotic centrosome function., Zeng C., Microsc Res Tech. June 1, 2000; 49 (5): 467-77.

TPX2, A novel xenopus MAP involved in spindle pole organization., Wittmann T, Wilm M, Karsenti E, Vernos I., J Cell Biol. June 26, 2000; 149 (7): 1405-18.                    

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5., Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ., J Cell Biol. September 4, 2000; 150 (5): 975-88.                    

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly., Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K., Cell. January 12, 2001; 104 (1): 95-106.

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly., Wiese C, Wilde A, Moore MS, Adam SA, Merdes A, Zheng Y., Science. January 26, 2001; 291 (5504): 653-6.

A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization., Du Q, Stukenberg PT, Macara IG., Nat Cell Biol. December 1, 2001; 3 (12): 1069-75.

[Clinical significance of fluoroscopic patterns specific for the mitotic spindle in patients with rheumatic diseases]., Grypiotis P, Ruffatti A, Tonello M, Winzler C, Radu C, Zampieri S, Favaro M, Calligaro A, Todesco S., Reumatismo. January 1, 2002; 54 (3): 232-7.

Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules., Haren L, Merdes A., J Cell Sci. May 1, 2002; 115 (Pt 9): 1815-24.

Assembly of centrosomal proteins and microtubule organization depends on PCM-1., Dammermann A, Merdes A., J Cell Biol. October 28, 2002; 159 (2): 255-66.                

Two distinct domains of protein 4.1 critical for assembly of functional nuclei in vitro., Krauss SW, Heald R, Lee G, Nunomura W, Gimm JA, Mohandas N, Chasis JA., J Biol Chem. November 15, 2002; 277 (46): 44339-46.

hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division., Garrett S, Auer K, Compton DA, Kapoor TM., Curr Biol. December 10, 2002; 12 (23): 2055-9.

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly., Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y., Nat Cell Biol. March 1, 2003; 5 (3): 242-8.

Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle., Stenoien DL, Sen S, Mancini MA, Brinkley BR., Cell Motil Cytoskeleton. June 1, 2003; 55 (2): 134-46.

XMAP215, XKCM1, NuMA, and cytoplasmic dynein are required for the assembly and organization of the transient microtubule array during the maturation of Xenopus oocytes., Becker BE, Romney SJ, Gard DL., Dev Biol. September 15, 2003; 261 (2): 488-505.                

Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles., Gehmlich K, Haren L, Merdes A., EMBO Rep. January 1, 2004; 5 (1): 97-103.

Two protein 4.1 domains essential for mitotic spindle and aster microtubule dynamics and organization in vitro., Krauss SW, Lee G, Chasis JA, Mohandas N, Heald R., J Biol Chem. June 25, 2004; 279 (26): 27591-8.

Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles., Gaetz J, Kapoor TM., J Cell Biol. August 16, 2004; 166 (4): 465-71.          

XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly., Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R., Curr Biol. October 26, 2004; 14 (20): 1801-11.            

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function., Chang P, Coughlin M, Mitchison TJ., Nat Cell Biol. November 1, 2005; 7 (11): 1133-9.

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly., Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM., Cell. November 3, 2006; 127 (3): 539-52.

A role for NuSAP in linking microtubules to mitotic chromosomes., Ribbeck K, Raemaekers T, Carmeliet G, Mattaj IW., Curr Biol. February 6, 2007; 17 (3): 230-6.

Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle., Brown KS, Blower MD, Maresca TJ, Grammer TC, Harland RM, Heald R., J Cell Biol. March 12, 2007; 176 (6): 765-70.        

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity., Zhang X, Ems-McClung SC, Walczak CE., Mol Biol Cell. July 1, 2008; 19 (7): 2752-65.

Directly probing the mechanical properties of the spindle and its matrix., Gatlin JC, Matov A, Danuser G, Mitchison TJ, Salmon ED., J Cell Biol. February 22, 2010; 188 (4): 481-9.          

A computational model predicts Xenopus meiotic spindle organization., Loughlin R, Heald R, Nédélec F., J Cell Biol. December 27, 2010; 191 (7): 1239-49.        

Microtubule assembly in meiotic extract requires glycogen., Groen AC, Coughlin M, Mitchison TJ., Mol Biol Cell. September 1, 2011; 22 (17): 3139-51.            

Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts., Halpin D, Kalab P, Wang J, Weis K, Heald R., PLoS Biol. December 1, 2011; 9 (12): e1001225.        

Inscuteable and NuMA proteins bind competitively to Leu-Gly-Asn repeat-enriched protein (LGN) during asymmetric cell divisions., Culurgioni S, Alfieri A, Pendolino V, Laddomada F, Mapelli M., Proc Natl Acad Sci U S A. December 27, 2011; 108 (52): 20998-1003.

Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol., Mitchison TJ, Nguyen P, Coughlin M, Groen AC., Mol Biol Cell. May 1, 2013; 24 (10): 1559-73.                  

FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis., Petridou NI, Skourides PA., Nat Commun. January 1, 2014; 5 5240.      

Transportin acts to regulate mitotic assembly events by target binding rather than Ran sequestration., Bernis C, Swift-Taylor B, Nord M, Carmona S, Chook YM, Forbes DJ., Mol Biol Cell. April 1, 2014; 25 (7): 992-1009.                  

The Ran-GTP gradient spatially regulates XCTK2 in the spindle., Weaver LN, Ems-McClung SC, Chen SH, Yang G, Shaw SL, Walczak CE., Curr Biol. June 1, 2015; 25 (11): 1509-14.

Regulation of mitotic spindle assembly factor NuMA by Importin-β., Chang CC, Huang TL, Shimamoto Y, Tsai SY, Hsia KC., J Cell Biol. November 6, 2017; 216 (11): 3453-3462.          

Induction of a Spindle-Assembly-Competent M Phase in Xenopus Egg Extracts., Bisht JS, Tomschik M, Gatlin JC., Curr Biol. April 22, 2019; 29 (8): 1273-1285.e5.              

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