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Summary Expression Phenotypes Gene Literature (589) GO Terms (2) Nucleotides (337) Proteins (8) Interactants (677) Wiki

Papers associated with GABA(A) receptor-associated protein

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The anticonvulsant zonisamide positively modulates recombinant and native glycine receptors at clinically relevant concentrations., Devenish SO, Winters BL, Anderson LL, Arnold JC, McGregor IS, Vaughan CW, Chebib M, Absalom NL., Neuropharmacology. January 1, 2021; 182 108371.

A Benzodiazepine Ligand with Improved GABAA Receptor α5-Subunit Selectivity Driven by Interactions with Loop C., Simeone X, Koniuszewski F, Müllegger M, Smetka A, Steudle F, Puthenkalam R, Ernst M, Scholze P., Mol Pharmacol. January 1, 2021; 99 (1): 39-48.            

GABAA Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties., Ordaz RP, Garay E, Limon A, Pérez-Samartín A, Sánchez-Gómez MV, Robles-Martínez L, Cisneros-Mejorado A, Matute C, Arellano RO., Mol Pharmacol. January 1, 2021; 99 (2): 133-146.

''Proximity frequencies'' a new parameter to evaluate the profile of GABAAR modulators., Crocetti L, Guerrini G, Cantini N, Vergelli C, Melani F, Mascia MP, Giovannoni MP., Bioorg Med Chem Lett. January 1, 2021; 34 127755.

Efficient expression of concatenated α1β2δ and α1β3δ GABAA receptors, their pharmacology and stoichiometry., Liao VWY, Chebib M, Ahring PK., Br J Pharmacol. January 1, 2021; 178 (7): 1556-1573.

In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders., Grupe M, Bentzen BH, Benned-Jensen T, Nielsen V, Frederiksen K, Jensen HS, Jacobsen AM, Skibsbye L, Sams AG, Grunnet M, Rottländer M, Bastlund JF., Eur J Pharmacol. November 15, 2020; 887 173440.

A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors., Shalabi AR, Yu Z, Zhou X, Jounaidi Y, Chen H, Dai J, Kent DE, Feng HJ, Forman SA, Cohen JB, Bruzik KS, Miller KW., Eur J Med Chem. May 15, 2020; 194 112261.

The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents., McGrath M, Tolia M, Raines DE., Pharmacol Rep. February 1, 2020; 72 (1): 260-266.

Erythropoietin Increases GABAA Currents in Human Cortex from TLE Patients., Roseti C, Cifelli P, Ruffolo G, Barbieri E, Guescini M, Esposito V, Di Gennaro G, Limatola C, Giovannelli A, Aronica E, Palma E., Neuroscience. January 1, 2020; 439 153-162.

Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome., Ruffolo G, Cifelli P, Miranda-Lourenço C, De Felice E, Limatola C, Sebastião AM, Diógenes MJ, Aronica E, Palma E., Neuroscience. January 1, 2020; 439 146-152.

PNU-120596, a positive allosteric modulator of mammalian α7 nicotinic acetylcholine receptor, is a negative modulator of ligand-gated chloride-selective channels of the gastropod Lymnaea stagnalis., Vulfius CA, Lebedev DS, Kryukova EV, Kudryavtsev DS, Kolbaev SN, Utkin YN, Tsetlin VI., J Neurochem. January 1, 2020; 155 (3): 274-284.

Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons., Joshi S, Roden WH, Kapur J, Jansen LA., Ann Clin Transl Neurol. January 1, 2020; 7 (4): 527-542.            

Functional characterization of the antiepileptic drug candidate, padsevonil, on GABAA receptors., Niespodziany I, Ghisdal P, Mullier B, Wood M, Provins L, Kaminski RM, Wolff C., Epilepsia. January 1, 2020; 61 (5): 914-923.                

Cloning and Expression of Cockroach α7 Nicotinic Acetylcholine Receptor Subunit., Cartereau A, Taillebois E, Selvam B, Martin C, Graton J, Le Questel JY, Thany SH., Front Physiol. January 1, 2020; 11 418.            

Apremilast regulates acute effects of ethanol and other GABAergic drugs via protein kinase A-dependent signaling., Blednov YA, Borghese CM, Dugan MP, Pradhan S, Thodati TM, Kichili NR, Harris RA, Messing RO., Neuropharmacology. January 1, 2020; 178 108220.

Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions., Ihara M, Furutani S, Shigetou S, Shimada S, Niki K, Komori Y, Kamiya M, Koizumi W, Magara L, Hikida M, Noguchi A, Okuhara D, Yoshinari Y, Kondo S, Tanimoto H, Niwa R, Sattelle DB, Matsuda K., Proc Natl Acad Sci U S A. January 1, 2020; 117 (28): 16283-16291.        

Reduced Activation of the Synaptic-Type GABAA Receptor Following Prolonged Exposure to Low Concentrations of Agonists: Relationship between Tonic Activity and Desensitization., Pierce SR, Germann AL, Evers AS, Steinbach JH, Akk G., Mol Pharmacol. January 1, 2020; 98 (6): 762-769.

The desensitization pathway of GABAA receptors, one subunit at a time., Gielen M, Barilone N, Corringer PJ., Nat Commun. January 1, 2020; 11 (1): 5369.                

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) acutely affect human α1β2γ2L GABAA receptor and spontaneous neuronal network function in vitro., Tukker AM, Bouwman LMS, van Kleef RGDM, Hendriks HS, Legler J, Westerink RHS., Sci Rep. January 1, 2020; 10 (1): 5311.

Differential Coassembly of α1-GABAARs Associated with Epileptic Encephalopathy., Hannan S, Affandi AHB, Minere M, Jones C, Goh P, Warnes G, Popp B, Trollmann R, Nizetic D, Smart TG., J Neurosci. January 1, 2020; 40 (29): 5518-5530.

Competitive Antagonism of Etomidate Action by Diazepam., McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE., Anesthesiology. January 1, 2020; 133 (3): 583-594.

Natural product incarvillateine aggravates epileptic seizures by inhibiting GABAA currents., Bian X, Zhang Y, Huang B, Wang X, Wang G, Zhu Y, Liu Y, Liang J, Jia Y, Wang K., Eur J Pharmacol. September 5, 2019; 858 172496.

A FLIPR Assay for Discovery of GABAA Receptor Modulators of Natural Origin., Faleschini MT, Maier A, Fankhauser S, Thasis K, Hebeisen S, Hamburger M, Butterweck V., Planta Med. August 1, 2019; 85 (11-12): 925-933.

Multiple actions of fenamates and other nonsteroidal anti-inflammatory drugs on GABAA receptors., Mansikkamäki S, Sinkkonen ST, Korpi ER, Lüddens H., Eur J Pharmacol. June 15, 2019; 853 247-255.

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model., Sun LL, Yang TY, Wei NN, Lu W, Jiao WX, Zhou QQ, Miao YZ, Gao Q, Wang XT, Sun Q, Wang K., Acta Pharmacol Sin. June 1, 2019; 40 (6): 737-745.

Synthesis of New GABAA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold., Guerrini G, Vergelli C, Cantini N, Giovannoni MP, Daniele S, Mascia MP, Martini C, Crocetti L., Int J Mol Sci. March 21, 2019; 20 (6):                 

Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice., Li Y, Sun L, Yang T, Jiao W, Tang J, Huang X, Huang Z, Meng Y, Luo L, Wang X, Bian X, Zhang F, Wang K, Sun Q., J Med Chem. January 1, 2019; 62 (1): 159-173.

Ketone body modulation of ligand-gated ion channels., Pflanz NC, Daszkowski AW, James KA, Mihic SJ., Neuropharmacology. January 1, 2019; 148 21-30.

Interaction of insecticides with heteromeric GABA-gated chloride channels from zebrafish Danio rerio (Hamilton)., Huang QT, Sheng CW, Jiang J, Tang T, Jia ZQ, Han ZJ, Zhao CQ., J Hazard Mater. January 1, 2019; 366 643-650.

Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors., Spirova EN, Ivanov IA, Kasheverov IE, Kudryavtsev DS, Shelukhina IV, Garifulina AI, Son LV, Lummis SCR, Malca-Garcia GR, Bussmann RW, Hennig L, Giannis A, Tsetlin VI., PLoS One. January 1, 2019; 14 (1): e0210182.        

Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization., Chisari M, Wilding TJ, Brunwasser S, Krishnan K, Qian M, Benz A, Huettner JE, Zorumski CF, Covey DF, Mennerick S., Neuropharmacology. January 1, 2019; 144 91-103.

In vitro and in vivo GABAA Receptor Interaction of the Propanidid Metabolite 4-(2-[Diethylamino]-2-Oxoethoxy)-3-Methoxy-Benzeneacetic Acid., Cenani A, Brosnan RJ, Knych HK., Pharmacology. January 1, 2019; 103 (1-2): 10-16.

Involvement of the GABAA receptor α subunit in the mode of action of etifoxine., Mattei C, Taly A, Soualah Z, Saulais O, Henrion D, Guérineau NC, Verleye M, Legros C., Pharmacol Res. January 1, 2019; 145 104250.

Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant α1β3γ2L GABAA Receptors Indicates Selectivity and Crosstalk among Intersubunit Transmembrane Anesthetic Sites., Szabo A, Nourmahnad A, Halpin E, Forman SA., Mol Pharmacol. January 1, 2019; 95 (4): 408-417.

Analysis of GABAA Receptor Activation by Combinations of Agonists Acting at the Same or Distinct Binding Sites., Shin DJ, Germann AL, Covey DF, Steinbach JH, Akk G., Mol Pharmacol. January 1, 2019; 95 (1): 70-81.

Steady-State Activation and Modulation of the Concatemeric α1β2γ2L GABAA Receptor., Germann AL, Pierce SR, Burbridge AB, Steinbach JH, Akk G., Mol Pharmacol. January 1, 2019; 96 (3): 320-329.

Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands., Germann AL, Pierce SR, Senneff TC, Burbridge AB, Steinbach JH, Akk G., Physiol Rep. January 1, 2019; 7 (18): e14230.              

Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits., Yang X, Jounaidi Y, Mukherjee K, Fantasia RJ, Liao EC, Yu B, Forman SA., Anesthesiology. January 1, 2019; 131 (6): 1276-1291.

Functional genomics of epilepsy-associated mutations in the GABAA receptor subunits reveal that one mutation impairs function and two are catastrophic., Absalom NL, Ahring PK, Liao VW, Balle T, Jiang T, Anderson LL, Arnold JC, McGregor IS, Bowen MT, Chebib M., J Biol Chem. January 1, 2019; 294 (15): 6157-6171.                  

Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions., Anderson LL, Absalom NL, Abelev SV, Low IK, Doohan PT, Martin LJ, Chebib M, McGregor IS, Arnold JC., Epilepsia. January 1, 2019; 60 (11): 2224-2234.                    

Multiple functional neurosteroid binding sites on GABAA receptors., Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS., PLoS Biol. January 1, 2019; 17 (3): e3000157.            

Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo., Kent DE, Savechenkov PY, Bruzik KS, Miller KW., Br J Pharmacol. January 1, 2019; 176 (24): 4760-4772.

Steady-state activation of the high-affinity isoform of the α4β2δ GABAA receptor., Pierce SR, Senneff TC, Germann AL, Akk G., Sci Rep. January 1, 2019; 9 (1): 15997.

Anesthetic-sensitive ion channel modulation is associated with a molar water solubility cut-off., Brosnan RJ, Pham TL., BMC Pharmacol Toxicol. September 14, 2018; 19 (1): 57.                

The roles of aromatic residues in the glycine receptor transmembrane domain., Tang B, Lummis SCR., BMC Neurosci. September 6, 2018; 19 (1): 53.                  

Negative modulation of the GABAA ρ1 receptor function by l-cysteine., Beltrán González AN, Vicentini F, Calvo DJ., J Neurochem. January 1, 2018; 144 (1): 50-57.

Towards functional selectivity for α6β3γ2 GABAA receptors: a series of novel pyrazoloquinolinones., Treven M, Siebert DCB, Holzinger R, Bampali K, Fabjan J, Varagic Z, Wimmer L, Steudle F, Scholze P, Schnürch M, Mihovilovic MD, Ernst M., Br J Pharmacol. January 1, 2018; 175 (3): 419-428.          

GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC50 and Basal Activity., Akk G, Shin DJ, Germann AL, Steinbach JH., Mol Pharmacol. January 1, 2018; 93 (2): 90-100.

Alphaxalone Binds in Inner Transmembrane β+-α- Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors., Ziemba AM, Szabo A, Pierce DW, Haburcak M, Stern AT, Nourmahnad A, Halpin ES, Forman SA., Anesthesiology. January 1, 2018; 128 (2): 338-351.

Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice., Xu NZ, Ernst M, Treven M, Cerne R, Wakulchik M, Li X, Jones TM, Gleason SD, Morrow D, Schkeryantz JM, Rahman MT, Li G, Poe MM, Cook JM, Witkin JM., Psychopharmacology (Berl). January 1, 2018; 235 (4): 1151-1161.

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