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Summary Expression Phenotypes Gene Literature (132) GO Terms (1) Nucleotides (120) Proteins (61) Interactants (71) Wiki
XB--977698

Papers associated with asic1



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Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells., Lyukmanova EN, Zaigraev MM, Kulbatskii DS, Isaev AB, Kukushkin ID, Bychkov ML, Shulepko MA, Chugunov AO, Kirpichnikov MP., Toxins (Basel). October 13, 2023; 15 (10):               


Extracellular intersubunit interactions modulate epithelial Na+ channel gating., Zhang L, Wang X, Chen J, Sheng S, Kleyman TR., J Biol Chem. March 1, 2023; 299 (3): 102914.                


A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels., Pinheiro-Junior EL, Kalina R, Gladkikh I, Leychenko E, Tytgat J, Peigneur S., Mar Drugs. February 17, 2022; 20 (2):


Mambalgin-2 Inhibits Lung Adenocarcinoma Growth and Migration by Selective Interaction With ASIC1/α-ENaC/γ-ENaC Heterotrimer., Sudarikova AV, Bychkov ML, Kulbatskii DS, Chubinskiy-Nadezhdin VI, Shlepova OV, Shulepko MA, Koshelev SG, Kirpichnikov MP, Lyukmanova EN., Front Oncol. January 1, 2022; 12 904742.


Apamin structure and pharmacology revisited., Kuzmenkov AI, Peigneur S, Nasburg JA, Mineev KS, Nikolaev MV, Pinheiro-Junior EL, Arseniev AS, Wulff H, Tytgat J, Vassilevski AA., Front Pharmacol. January 1, 2022; 13 977440.          


Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket., Leisle L, Margreiter M, Ortega-Ramírez A, Cleuvers E, Bachmann M, Rossetti G, Gründer S., J Med Chem. September 23, 2021; 64 (18): 13299-13311.


The Neuropeptide Nocistatin Is Not a Direct Agonist of Acid-Sensing Ion Channel 1a (ASIC1a)., Kuspiel S, Wiemuth D, Gründer S., Biomolecules. April 13, 2021; 11 (4):


Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a., Salinas M, Kessler P, Douguet D, Sarraf D, Tonali N, Thai R, Servent D, Lingueglia E., Neuropharmacology. March 1, 2021; 185 108453.


Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a., Bychkov M, Shulepko M, Osmakov D, Andreev Y, Sudarikova A, Vasileva V, Pavlyukov MS, Latyshev YA, Potapov AA, Kirpichnikov M, Shenkarev ZO, Lyukmanova E., Cancers (Basel). July 8, 2020; 12 (7):                       


APETx-Like Peptides from the Sea Anemone Heteractis crispa, Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels., Kalina RS, Koshelev SG, Zelepuga EA, Kim NY, Kozlov SA, Kozlovskaya EP, Monastyrnaya MM, Gladkikh IN., Toxins (Basel). April 20, 2020; 12 (4):


Mechanism and site of action of big dynorphin on ASIC1a., Borg CB, Braun N, Heusser SA, Bay Y, Weis D, Galleano I, Lund C, Tian W, Haugaard-Kedström LM, Bennett EP, Lynagh T, Strømgaard K, Andersen J, Pless SA., Proc Natl Acad Sci U S A. March 31, 2020; 117 (13): 7447-7454.


Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties., Osmakov DI, Koshelev SG, Palikov VA, Palikova YA, Shaykhutdinova ER, Dyachenko IA, Andreev YA, Kozlov SA., Toxins (Basel). September 18, 2019; 11 (9):         


Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline., Osmakov DI, Koshelev SG, Lyukmanova EN, Shulepko MA, Andreev YA, Illes P, Kozlov SA., Biomolecules. August 2, 2019; 9 (8):                   


Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors., Florentino IF, Silva DPB, Cardoso CS, Menegatti R, de Carvalho FS, Lião LM, Pinto PM, Peigneur S, Costa EA, Tytgat J., Biomed Pharmacother. July 1, 2019; 115 108915.


Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system., Ilyaskin AV, Sure F, Nesterov V, Haerteis S, Korbmacher C., J Gen Physiol. June 3, 2019; 151 (6): 820-833.                    


A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels., Wu Y, Chen Z, Canessa CM., Elife. May 2, 2019; 8               


Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands., Barth D, Fronius M., Sci Rep. May 1, 2019; 9 (1): 6781.                  


The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analogues., Cristofori-Armstrong B, Saez NJ, Chassagnon IR, King GF, Rash LD., Biochem Pharmacol. May 1, 2019; 163 381-390.


Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides., Bargeton B, Iwaszkiewicz J, Bonifacio G, Roy S, Zoete V, Kellenberger S., Sci Rep. February 22, 2019; 9 (1): 2599.            


Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators., Vyvers A, Schmidt A, Wiemuth D, Gründer S., Sci Rep. December 20, 2018; 8 (1): 18000.                        


Thumb domains of the three epithelial Na+ channel subunits have distinct functions., Sheng S, Chen J, Mukherjee A, Yates ME, Buck TM, Brodsky JL, Tolino MA, Hughey RP, Kleyman TR., J Biol Chem. November 9, 2018; 293 (45): 17582-17592.  


The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand-Sensing Domain., Reiners M, Margreiter MA, Oslender-Bujotzek A, Rossetti G, Gründer S, Schmidt A., Mol Pharmacol. October 1, 2018; 94 (4): 1114-1124.


Determinants of selective ion permeation in the epithelial Na+ channel., Yang L, Palmer LG., J Gen Physiol. October 1, 2018; 150 (10): 1397-1407.                            


Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8., Matthewman C, Johnson CK, Miller DM, Bianchi L., Am J Physiol Cell Physiol. August 1, 2018; 315 (2): C155-C163.          


Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain., Lee JYP, Saez NJ, Cristofori-Armstrong B, Anangi R, King GF, Smith MT, Rash LD., Br J Pharmacol. June 1, 2018; 175 (12): 2204-2218.


Inhalational anesthetics accelerate desensitization of acid-sensing ion channels., Lehmke L, Coburn M, Möller M, Blaumeiser-Debarry R, Lenzig P, Wiemuth D, Gründer S., Neuropharmacology. June 1, 2018; 135 496-505.


New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels., Kalina R, Gladkikh I, Dmitrenok P, Chernikov O, Koshelev S, Kvetkina A, Kozlov S, Kozlovskaya E, Monastyrnaya M., Peptides. June 1, 2018; 104 41-49.


Molecular basis of inhibition of acid sensing ion channel 1A by diminazene., Krauson AJ, Rooney JG, Carattino MD., PLoS One. May 15, 2018; 13 (5): e0196894.          


Dimerization of the voltage-sensing phosphatase controls its voltage-sensing and catalytic activity., Rayaprolu V, Royal P, Stengel K, Sandoz G, Kohout SC., J Gen Physiol. May 7, 2018; 150 (5): 683-696.                        


The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel., Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, Nörenberg W, Franke H, Gölöncsér F, Sperlágh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P, Illes P., Nat Commun. April 10, 2018; 9 (1): 1354.                    


Proton-independent activation of acid-sensing ion channel 3 by an alkaloid, lindoldhamine, from Laurus nobilis., Osmakov DI, Koshelev SG, Andreev YA, Dubinnyi MA, Kublitski VS, Efremov RG, Sobolevsky AI, Kozlov SA., Br J Pharmacol. March 1, 2018; 175 (6): 924-937.


The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide., Yang XN, Niu YY, Liu Y, Yang Y, Wang J, Cheng XY, Liang H, Wang HS, Hu YM, Lu XY, Zhu MX, Xu TL, Tian Y, Yu Y., J Biol Chem. December 29, 2017; 292 (52): 21662-21675.


Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a)., Schmidt A, Rossetti G, Joussen S, Gründer S., Mol Pharmacol. December 1, 2017; 92 (6): 665-675.


Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1., Er SY, Cristofori-Armstrong B, Escoubas P, Rash LD., Neuropharmacology. December 1, 2017; 127 185-195.


Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen., Lynagh T, Romero-Rojo JL, Lund C, Pless SA., J Med Chem. October 12, 2017; 60 (19): 8192-8200.


Pharmacological modulation of Acid-Sensing Ion Channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ)., Besson T, Lingueglia E, Salinas M., Neuropharmacology. October 1, 2017; 125 429-440.


An implantable ENG detector with in-system velocity selective recording (VSR) capability., Clarke C, Rieger R, Schuettler M, Donaldson N, Taylor J., Med Biol Eng Comput. June 1, 2017; 55 (6): 885-895.


A selectivity filter at the intracellular end of the acid-sensing ion channel pore., Lynagh T, Flood E, Boiteux C, Wulf M, Komnatnyy VV, Colding JM, Allen TW, Pless SA., Elife. May 12, 2017; 6                   


Bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel (ASIC1a)., Ilyaskin AV, Diakov A, Korbmacher C, Haerteis S., Physiol Rep. February 1, 2017; 5 (3):             


Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels., Matthewman C, Miller-Fleming TW, Miller DM, Bianchi L., Am J Physiol Cell Physiol. December 1, 2016; 311 (6): C920-C930.


Activation of the Human Epithelial Sodium Channel (ENaC) by Bile Acids Involves the Degenerin Site., Ilyaskin AV, Diakov A, Korbmacher C, Haerteis S., J Biol Chem. September 16, 2016; 291 (38): 19835-47.


Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1., Joeres N, Augustinowski K, Neuhof A, Assmann M, Gründer S., Sci Rep. June 9, 2016; 6 27647.              


The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization., Krauson AJ, Carattino MD., J Biol Chem. May 20, 2016; 291 (21): 11407-19.


Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain., Diochot S, Alloui A, Rodrigues P, Dauvois M, Friend V, Aissouni Y, Eschalier A, Lingueglia E, Baron A., Pain. March 1, 2016; 157 (3): 552-559.


Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition., Mourier G, Salinas M, Kessler P, Stura EA, Leblanc M, Tepshi L, Besson T, Diochot S, Baron A, Douguet D, Lingueglia E, Servent D., J Biol Chem. February 5, 2016; 291 (6): 2616-29.


Optogenetic approaches addressing extracellular modulation of neural excitability., Ferenczi EA, Vierock J, Atsuta-Tsunoda K, Tsunoda SP, Ramakrishnan C, Gorini C, Thompson K, Lee SY, Berndt A, Perry C, Minniberger S, Vogt A, Mattis J, Prakash R, Delp S, Deisseroth K, Hegemann P., Sci Rep. January 22, 2016; 6 23947.                


Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a., Saez NJ, Deplazes E, Cristofori-Armstrong B, Chassagnon IR, Lin X, Mobli M, Mark AE, Rash LD, King GF., Br J Pharmacol. October 1, 2015; 172 (20): 4985-95.


The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface., van Bemmelen MX, Huser D, Gautschi I, Schild L., PLoS One. August 4, 2015; 10 (8): e0135191.              


Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a., Gwiazda K, Bonifacio G, Vullo S, Kellenberger S., J Biol Chem. July 17, 2015; 290 (29): 17956-17966.


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD., Sci Rep. January 12, 2015; 5 14763.                                

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