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Summary Expression Phenotypes Gene Literature (182) GO Terms (0) Nucleotides (29) Proteins (17) Interactants (219) Wiki

Papers associated with kcnh1

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1 paper(s) referencing morpholinos

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External Cd2+ and protons activate the hyperpolarization-gated K+ channel KAT1 at the voltage sensor., Zhou Y, Assmann SM, Jegla T., J Gen Physiol. January 1, 2021; 153 (1):                           

Nonanal modulates oviposition preference in female Helicoverpa assulta (Lepidoptera: Noctuidae) via the activation of peripheral neurons., Wang C, Li G, Miao C, Zhao M, Wang B, Guo X., Pest Manag Sci. September 1, 2020; 76 (9): 3159-3167.          

Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity., Wang ZJ, Soohoo SM, Tiwari PB, Piszczek G, Brelidze TI., J Biol Chem. March 27, 2020; 295 (13): 4114-4123.

Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity., Wang ZJ, Soohoo SM, Tiwari PB, Piszczek G, Brelidze TI., J Biol Chem. January 1, 2020; 295 (13): 4114-4123.            

An Orphan Pheromone Receptor Affects the Mating Behavior of Helicoverpa armigera., Cao S, Huang T, Shen J, Liu Y, Wang G., Front Physiol. January 1, 2020; 11 413.        

Bipolar switching by HCN voltage sensor underlies hyperpolarization activation., Cowgill J, Klenchin VA, Alvarez-Baron C, Tewari D, Blair A, Chanda B., Proc Natl Acad Sci U S A. January 1, 2019; 116 (2): 670-678.                        

Regulation of Eag1 gating by its intracellular domains., Whicher JR, MacKinnon R., Elife. January 1, 2019; 8                     

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels., Wang ZJ, Tiwari PB, Üren A, Brelidze TI., BMC Pharmacol Toxicol. January 1, 2019; 20 (1): 42.                        

A novel lineage of candidate pheromone receptors for sex communication in moths., Bastin-Héline L, de Fouchier A, Cao S, Koutroumpa F, Caballero-Vidal G, Robakiewicz S, Monsempes C, François MC, Ribeyre T, Maria A, Chertemps T, de Cian A, Walker WB, Wang G, Jacquin-Joly E, Montagné N., Elife. January 1, 2019; 8         

Reverse chemical ecology approach for the identification of an oviposition attractant for Culex quinquefasciatus., Choo YM, Xu P, Hwang JK, Zeng F, Tan K, Bhagavathy G, Chauhan KR, Leal WS., Proc Natl Acad Sci U S A. January 1, 2018; 115 (4): 714-719.          

Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain., Kume S, Shimomura T, Tateyama M, Kubo Y., J Physiol. January 1, 2018; 596 (19): 4629-4650.

Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels., Dai G, James ZM, Zagotta WN., J Gen Physiol. January 1, 2018; 150 (4): 625-635.            

The intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation., Zhao Y, Goldschen-Ohm MP, Morais-Cabral JH, Chanda B, Robertson GA., J Gen Physiol. February 1, 2017; 149 (2): 249-260.                

Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels., Dai G, Zagotta WN., Elife. January 1, 2017; 6               

A Female-Biased Odorant Receptor from Apolygus lucorum (Meyer-Dür) Tuned to Some Plant Odors., Zhang Z, Zhang M, Yan S, Wang G, Liu Y., Int J Mol Sci. July 28, 2016; 17 (8):           

hERG Channel Blocking Ipecac Alkaloids Identified by Combined In Silico - In Vitro Screening., Kratz JM, Mair CE, Oettl SK, Saxena P, Scheel O, Schuster D, Hering S, Rollinger JM., Planta Med. July 1, 2016; 82 (11-12): 1009-15.

A Conserved Odorant Receptor Tuned to Floral Volatiles in Three Heliothinae Species., Cao S, Liu Y, Guo M, Wang G., PLoS One. January 1, 2016; 11 (5): e0155029.          

Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels., Wu W, Gardner A, Sachse FB, Sanguinetti MC., Mol Pharmacol. January 1, 2016; 90 (4): 469-82.

Mitragynine and its potential blocking effects on specific cardiac potassium channels., Tay YL, Teah YF, Chong YM, Jamil MFA, Kollert S, Adenan MI, Wahab HA, Döring F, Wischmeyer E, Tan ML., Toxicol Appl Pharmacol. January 1, 2016; 305 22-39.

Genome evolution in the allotetraploid frog Xenopus laevis., Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS., Nature. January 1, 2016; 538 (7625): 336-343.                              

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain., Lörinczi E, Helliwell M, Finch A, Stansfeld PJ, Davies NW, Mahaut-Smith M, Muskett FW, Mitcheson JS., J Biol Chem. January 1, 2016; 291 (34): 17907-18.                

Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase in Xenopus Oocytes., Ramos Gomes F, Romaniello V, Sánchez A, Weber C, Narayanan P, Psol M, Pardo LA., J Biol Chem. December 18, 2015; 290 (51): 30351-65.              

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD., Sci Rep. September 21, 2015; 5 14763.                                

HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana., Du K, De Mieri M, Saxena P, Phungula KV, Wilhelm A, Hrubaru MM, van Rensburg E, Zietsman PC, Hering S, van der Westhuizen JH, Hamburger M., Planta Med. August 1, 2015; 81 (12-13): 1154-62.

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome., Kortüm F, Caputo V, Bauer CK, Stella L, Ciolfi A, Alawi M, Bocchinfuso G, Flex E, Paolacci S, Dentici ML, Grammatico P, Korenke GC, Leuzzi V, Mowat D, Nair LD, Nguyen TT, Thierry P, White SM, Dallapiccola B, Pizzuti A, Campeau PM, Tartaglia M, Kutsche K., Nat Genet. June 1, 2015; 47 (6): 661-7.      

Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor., Li X, Martinson AS, Layden MJ, Diatta FH, Sberna AP, Simmons DK, Martindale MQ, Jegla TJ., J Exp Biol. February 15, 2015; 218 (Pt 4): 526-36.

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy., Simons C, Rash LD, Crawford J, Ma L, Cristofori-Armstrong B, Miller D, Ru K, Baillie GJ, Alanay Y, Jacquinet A, Debray FG, Verloes A, Shen J, Yesil G, Guler S, Yuksel A, Cleary JG, Grimmond SM, McGaughran J, King GF, Gabbett MT, Taft RJ., Nat Genet. January 1, 2015; 47 (1): 73-7.      

Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243., Wu W, Gardner A, Sanguinetti MC., Mol Pharmacol. January 1, 2015; 87 (3): 401-9.

Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN, Trudeau MC., PLoS One. January 1, 2015; 10 (4): e0123951.                

Facile functional analysis of insect odorant receptors expressed in the fruit fly: validation with receptors from taxonomically distant and closely related species., Ueira-Vieira C, Kimbrell DA, de Carvalho WJ, Leal WS., Cell Mol Life Sci. December 1, 2014; 71 (23): 4675-80.

The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains., Lin TF, Lin IW, Chen SC, Wu HH, Yang CS, Fang HY, Chiu MM, Jeng CJ., J Biol Chem. August 15, 2014; 289 (33): 22815-22834.

Natural products as potential human ether-a-go-go-related gene channel inhibitors - outcomes from a screening of widely used herbal medicines and edible plants., Schramm A, Jähne EA, Baburin I, Hering S, Hamburger M., Planta Med. August 1, 2014; 80 (12): 1045-50.

Natural products as potential human ether-a-go-go-related gene channel inhibitors - screening of plant-derived alkaloids., Schramm A, Saxena P, Chlebek J, Cahlíková L, Baburin I, Hering S, Hamburger M., Planta Med. June 1, 2014; 80 (8-9): 740-6.

Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr., Martinson AS, van Rossum DB, Diatta FH, Layden MJ, Rhodes SA, Martindale MQ, Jegla T., Proc Natl Acad Sci U S A. April 15, 2014; 111 (15): 5712-7.

Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate., Thouta S, Sokolov S, Abe Y, Clark SJ, Cheng YM, Claydon TW., Biophys J. March 4, 2014; 106 (5): 1057-69.

Up-regulation of hERG K⁺ channels by B-RAF., Pakladok T, Hosseinzadeh Z, Almilaji A, Lebedeva A, Shumilina E, Alesutan I, Lang F., PLoS One. January 1, 2014; 9 (1): e87457.          

The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels., Lin TF, Jow GM, Fang HY, Fu SJ, Wu HH, Chiu MM, Jeng CJ., PLoS One. January 1, 2014; 9 (10): e110423.                  

Chimeric hERG channels containing a tetramerization domain are functional and stable., Hausammann GJ, Grütter MG., Biochemistry. December 23, 2013; 52 (51): 9237-45.

AMP-activated protein kinase regulates hERG potassium channel., Almilaji A, Munoz C, Elvira B, Fajol A, Pakladok T, Honisch S, Shumilina E, Lang F, Föller M., Pflugers Arch. November 1, 2013; 465 (11): 1573-82.

Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel., Park MH, Lee SH, Chu DH, Won KH, Choi BH, Choe H, Jo SH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.

Blockade of the human ether-a-go-go-related gene potassium channel by ketamine., Zhang P, Xing J, Luo A, Feng J, Liu Z, Gao C, Ma J., J Pharm Pharmacol. September 1, 2013; 65 (9): 1321-8.

The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium., Dou Y, Goodchild SJ, Velde RV, Wu Y, Fedida D., Am J Physiol Cell Physiol. August 15, 2013; 305 (4): C468-78.

Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions., Ke Y, Ng CA, Hunter MJ, Mann SA, Heide J, Hill AP, Vandenberg JI., Biochem J. August 15, 2013; 454 (1): 69-77.

External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor., Kazmierczak M, Zhang X, Chen B, Mulkey DK, Shi Y, Wagner PG, Pivaroff-Ward K, Sassic JK, Bayliss DA, Jegla T., J Gen Physiol. June 1, 2013; 141 (6): 721-35.                        

Mapping of interactions between the N- and C-termini and the channel core in HERG K+ channels., de la Peña P, Machín A, Fernández-Trillo J, Domínguez P, Barros F., Biochem J. May 1, 2013; 451 (3): 463-74.

ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels., Garg V, Stary-Weinzinger A, Sanguinetti MC., Mol Pharmacol. April 1, 2013; 83 (4): 805-13.

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells., Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D., Br J Pharmacol. March 1, 2013; 168 (5): 1215-29.

Flavonoid regulation of EAG1 channels., Carlson AE, Brelidze TI, Zagotta WN., J Gen Physiol. March 1, 2013; 141 (3): 347-58.                  

Block of hERG K+ channel and prolongation of action potential duration by fluphenazine at submicromolar concentration., Hong HK, Lee BH, Park MH, Lee SH, Chu D, Kim WJ, Choe H, Hee Choi B, Jo SH., Eur J Pharmacol. February 28, 2013; 702 (1-3): 165-73.

The eag domain regulates hERG channel inactivation gating via a direct interaction., Gustina AS, Trudeau MC., J Gen Physiol. February 1, 2013; 141 (2): 229-41.                  

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