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Summary Expression Phenotypes Gene Literature (52) GO Terms (6) Nucleotides (41) Proteins (23) Interactants (65) Wiki
XB-GENEPAGE-990499

Papers associated with purinergic receptor P2X, ligand gated ion channel, 7

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Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation., Calzaferri F, Narros-Fernández P, de Pascual R, de Diego AMG, Nicke A, Egea J, García AG, de Los Ríos C., J Med Chem. January 1, 2021; 64 (4): 2272-2290.


Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists., T Pournara D, Durner A, Kritsi E, Papakostas A, Zoumpoulakis P, Nicke A, Koufaki M., ChemMedChem. January 1, 2020; 15 (24): 2530-2543.


SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player., Zakrzewicz A, Richter K, Zakrzewicz D, Siebers K, Damm J, Agné A, Hecker A, McIntosh JM, Chamulitrat W, Krasteva-Christ G, Manzini I, Tikkanen R, Padberg W, Janciauskiene S, Grau V., Front Immunol. January 1, 2019; 10 664.


Comparative Embryonic Spatio-Temporal Expression Profile Map of the Xenopus P2X Receptor Family., Blanchard C, Boué-Grabot E, Massé K., Front Cell Neurosci. January 1, 2019; 13 340.                    


Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors., Obrecht AS, Urban N, Schaefer M, Röse A, Kless A, Meents JE, Lampert A, Abdelrahman A, Müller CE, Schmalzing G, Hausmann R., Neuropharmacology. January 1, 2019; 158 107749.


Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization., McCarthy AE, Yoshioka C, Mansoor SE., Cell. January 1, 2019; 179 (3): 659-670.e13.


Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region., Huo H, Fryatt AG, Farmer LK, Schmid R, Evans RJ., J Biol Chem. January 1, 2018; 293 (33): 12820-12831.                


Interaction of Purinergic P2X4 and P2X7 Receptor Subunits., Schneider M, Prudic K, Pippel A, Klapperstück M, Braam U, Müller CE, Schmalzing G, Markwardt F., Front Pharmacol. January 1, 2017; 8 860.                        


Two P2X1 receptor transcripts able to form functional channels are present in most human monocytes., López-López C, Jaramillo-Polanco J, Portales-Pérez DP, Gómez-Coronado KS, Rodríguez-Meléndez JG, Cortés-García JD, Espinosa-Luna R, Montaño LM, Barajas-López C., Eur J Pharmacol. December 15, 2016; 793 82-88.


Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors., Richter K, Mathes V, Fronius M, Althaus M, Hecker A, Krasteva-Christ G, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Grau V., Sci Rep. January 1, 2016; 6 28660.            


Homodimeric anoctamin-1, but not homodimeric anoctamin-6, is activated by calcium increases mediated by the P2Y1 and P2X7 receptors., Stolz M, Klapperstück M, Kendzierski T, Detro-Dassen S, Panning A, Schmalzing G, Markwardt F., Pflugers Arch. October 1, 2015; 467 (10): 2121-40.


Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels., Allsopp RC, Evans RJ., J Biol Chem. June 5, 2015; 290 (23): 14556-66.                


Lidocaine preferentially inhibits the function of purinergic P2X7 receptors expressed in Xenopus oocytes., Okura D, Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Minami T, Kawasaki T, Sata T., Anesth Analg. March 1, 2015; 120 (3): 597-605.


Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages., Ousingsawat J, Wanitchakool P, Kmit A, Romao AM, Jantarajit W, Schreiber R, Kunzelmann K., Nat Commun. February 5, 2015; 6 6245.


Activation, permeability, and inhibition of astrocytic and neuronal large pore (hemi)channels., Hansen DB, Ye ZC, Calloe K, Braunstein TH, Hofgaard JP, Ransom BR, Nielsen MS, MacAulay N., J Biol Chem. September 19, 2014; 289 (38): 26058-26073.


Connexin hemichannel and pannexin channel electrophysiology: how do they differ?, Patel D, Zhang X, Veenstra RD., FEBS Lett. April 17, 2014; 588 (8): 1372-8.


ATP and potassium ions: a deadly combination for astrocytes., Jackson DG, Wang J, Keane RW, Scemes E, Dahl G., Sci Rep. February 26, 2014; 4 4576.                  


The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1., Wang J, Jackson DG, Dahl G., J Gen Physiol. May 1, 2013; 141 (5): 649-56.              


Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X₁ receptor channel currents., Choi SH, Kim HJ, Kim BR, Shin TJ, Hwang SH, Lee BH, Lee SM, Rhim H, Nah SY., Mol Cells. February 1, 2013; 35 (2): 142-50.


P2X4 receptor channels form large noncytolytic pores in resting and activated microglia., Bernier LP, Ase AR, Boué-Grabot E, Séguéla P., Glia. May 1, 2012; 60 (5): 728-37.


P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties., Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F., J Neurosci. March 21, 2012; 32 (12): 4284-96.


Cloning and functional analysis of P2X1b, a new variant in rat optic nerve that regulates the P2X1 receptor in a use-dependent manner., Rangel-Yescas GE, Vazquez-Cuevas FG, Garay E, Arellano RO., Acta Neurobiol Exp (Wars). January 1, 2012; 72 (1): 18-32.


The effect of anions on the human P2X7 receptor., Kubick C, Schmalzing G, Markwardt F., Biochim Biophys Acta. December 1, 2011; 1808 (12): 2913-22.


Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action., Marques-da-Silva C, Chaves MM, Castro NG, Coutinho-Silva R, Guimaraes MZ., Br J Pharmacol. July 1, 2011; 163 (5): 912-26.


Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor., Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, Müller CE., J Med Chem. February 10, 2011; 54 (3): 817-30.


Purinergic receptor-mediated Ca signaling in the olfactory bulb and the neurogenic area of the lateral ventricles., Hassenklöver T, Schulz P, Peters A, Schwartz P, Schild D, Manzini I., Purinergic Signal. December 1, 2010; 6 (4): 429-45.                


Effects of protons on macroscopic and single-channel currents mediated by the human P2X7 receptor., Flittiger B, Klapperstück M, Schmalzing G, Markwardt F., Biochim Biophys Acta. May 1, 2010; 1798 (5): 947-57.


A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice., Nicke A, Kuan YH, Masin M, Rettinger J, Marquez-Klaka B, Bender O, Górecki DC, Murrell-Lagnado RD, Soto F., J Biol Chem. September 18, 2009; 284 (38): 25813-22.


The pannexin 1 channel activates the inflammasome in neurons and astrocytes., Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G., J Biol Chem. July 3, 2009; 284 (27): 18143-51.


Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis., Roberts JA, Valente M, Allsopp RC, Watt D, Evans RJ., J Neurochem. May 1, 2009; 109 (4): 1042-52.              


A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP., Qiu F, Dahl G., Am J Physiol Cell Physiol. February 1, 2009; 296 (2): C250-5.


Homotrimeric complexes are the dominant assembly state of native P2X7 subunits., Nicke A., Biochem Biophys Res Commun. December 19, 2008; 377 (3): 803-8.


The P2X7 carboxyl tail is a regulatory module of P2X7 receptor channel activity., Becker D, Woltersdorf R, Boldt W, Schmitz S, Braam U, Schmalzing G, Markwardt F., J Biol Chem. September 12, 2008; 283 (37): 25725-34.


P2X7 receptor-Pannexin1 complex: pharmacology and signaling., Iglesias R, Locovei S, Roque A, Alberto AP, Dahl G, Spray DC, Scemes E., Am J Physiol Cell Physiol. September 1, 2008; 295 (3): C752-60.


Influence of extracellular monovalent cations on pore and gating properties of P2X7 receptor-operated single-channel currents., Riedel T, Schmalzing G, Markwardt F., Biophys J. August 1, 2007; 93 (3): 846-58.


Kinetics of P2X7 receptor-operated single channels currents., Riedel T, Lozinsky I, Schmalzing G, Markwardt F., Biophys J. April 1, 2007; 92 (7): 2377-91.


Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor., Acuña-Castillo C, Coddou C, Bull P, Brito J, Huidobro-Toro JP., J Neurochem. April 1, 2007; 101 (1): 17-26.


Characterization of ATP-gated P2X7 receptors in fish provides new insights into the mechanism of release of the leaderless cytokine interleukin-1 beta., López-Castejón G, Young MT, Meseguer J, Surprenant A, Mulero V., Mol Immunol. February 1, 2007; 44 (6): 1286-99.


A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages., Shemon AN, Sluyter R, Fernando SL, Clarke AL, Dao-Ung LP, Skarratt KK, Saunders BM, Tan KS, Gu BJ, Fuller SJ, Britton WJ, Petrou S, Wiley JS., J Biol Chem. January 27, 2006; 281 (4): 2079-86.


Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels., Silberberg SD, Chang TH, Swartz KJ., J Gen Physiol. April 1, 2005; 125 (4): 347-59.                


An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor., Gu BJ, Sluyter R, Skarratt KK, Shemon AN, Dao-Ung LP, Fuller SJ, Barden JA, Clarke AL, Petrou S, Wiley JS., J Biol Chem. July 23, 2004; 279 (30): 31287-95.


Dissecting individual current components of co-expressed human P2X1 and P2X7 receptors., Seyffert C, Schmalzing G, Markwardt F., Curr Top Med Chem. January 1, 2004; 4 (16): 1719-30.


P2X7 receptor cell surface expression and cytolytic pore formation are regulated by a distal C-terminal region., Smart ML, Gu B, Panchal RG, Wiley J, Cromer B, Williams DA, Petrou S., J Biol Chem. March 7, 2003; 278 (10): 8853-60.


Glu496Ala polymorphism of human P2X7 receptor does not affect its electrophysiological phenotype., Boldt W, Klapperstück M, Büttner C, Sadtler S, Schmalzing G, Markwardt F., Am J Physiol Cell Physiol. March 1, 2003; 284 (3): C749-56.


Pore formation is not associated with macroscopic redistribution of P2X7 receptors., Smart ML, Panchal RG, Bowser DN, Williams DA, Petrou S., Am J Physiol Cell Physiol. July 1, 2002; 283 (1): C77-84.


ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels., Chakfe Y, Seguin R, Antel JP, Morissette C, Malo D, Henderson D, Séguéla P., J Neurosci. April 15, 2002; 22 (8): 3061-9.


Formation of carnosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X4 and P2X7 receptors., Coddou C, Villalobos C, González J, Acuña-Castillo C, Loeb B, Huidobro-Toro JP., J Neurochem. February 1, 2002; 80 (4): 626-33.


Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors., Kim YC, Brown SG, Harden TK, Boyer JL, Dubyak G, King BF, Burnstock G, Jacobson KA., J Med Chem. February 1, 2001; 44 (3): 340-9.


Characteristics of P2X7 receptors from human B lymphocytes expressed in Xenopus oocytes., Klapperstück M, Büttner C, Böhm T, Schmalzing G, Markwardt F., Biochim Biophys Acta. August 25, 2000; 1467 (2): 444-56.


Pharmacological characterization of recombinant human and rat P2X receptor subtypes., Bianchi BR, Lynch KJ, Touma E, Niforatos W, Burgard EC, Alexander KM, Park HS, Yu H, Metzger R, Kowaluk E, Jarvis MF, van Biesen T., Eur J Pharmacol. July 2, 1999; 376 (1-2): 127-38.

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