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Summary Expression Phenotypes Gene Literature (59) GO Terms (6) Nucleotides (169) Proteins (52) Interactants (163) Wiki
XB-GENEPAGE-990636

Papers associated with topbp1



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Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts., Tatsukawa K, Sakamoto R, Kawasoe Y, Kubota Y, Tsurimoto T, Takahashi TS, Ohashi E., Nucleic Acids Res. April 12, 2024; 52 (6): 3146-3163.                  

TopBP1 utilises a bipartite GINS binding mode to support genome replication., Day M, Tetik B, Parlak M, Almeida-Hernández Y, Räschle M, Kaschani F, Siegert H, Marko A, Sanchez-Garcia E, Kaiser M, Barker IA, Pearl LH, Oliver AW, Boos D., Nat Commun. February 27, 2024; 15 (1): 1797.              

The structural mechanism of dimeric DONSON in replicative helicase activation., Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A., Mol Cell. November 16, 2023; 83 (22): 4017-4031.e9.                              

DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation., Kingsley G, Skagia A, Passaretti P, Fernandez-Cuesta C, Reynolds-Winczura A, Koscielniak K, Gambus A., Nucleic Acids Res. October 13, 2023; 51 (18): 9748-9763.                  

In silico protein interaction screening uncovers DONSON's role in replication initiation., Lim Y, Tamayo-Orrego L, Schmid E, Tarnauskaite Z, Kochenova OV, Gruar R, Muramatsu S, Lynch L, Schlie AV, Carroll PL, Chistol G, Reijns MAM, Kanemaki MT, Jackson AP, Walter JC., Science. September 22, 2023; 381 (6664): eadi3448.

Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation., Hashimoto Y, Sadano K, Miyata N, Ito H, Tanaka H., EMBO J. September 4, 2023; 42 (17): e114131.                          

MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks., Montales K, Ruis K, Lindsay H, Michael WM., PLoS One. August 2, 2022; 17 (8): e0271905.                

Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks., Ruis K, Huynh O, Montales K, Barr NA, Michael WM., J Biol Chem. July 1, 2022; 298 (7): 101992.            

The role of DDK and Treslin-MTBP in coordinating replication licensing and pre-initiation complex formation., Volpi I, Gillespie PJ, Chadha GS, Blow JJ., Open Biol. October 1, 2021; 11 (10): 210121.

Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus., Ciardo D, Haccard O, Narassimprakash H, Cornu D, Guerrera IC, Goldar A, Marheineke K., Nucleic Acids Res. September 27, 2021; 49 (17): 9851-9869.                                        

Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system., Montales K, Kim A, Ruis K, Michael WM., Sci Rep. January 11, 2021; 11 (1): 467.                

Biochemical analysis of TOPBP1 oligomerization., Kim A, Montales K, Ruis K, Senebandith H, Gasparyan H, Cowan Q, Michael WM., DNA Repair (Amst). December 1, 2020; 96 102973.

RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR., Lyu K, Kumagai A, Dunphy WG., Cell Cycle. April 1, 2019; 18 (8): 898-913.              

Claspin - checkpoint adaptor and DNA replication factor., Smits VAJ, Cabrera E, Freire R, Gillespie DA., FEBS J. February 1, 2019; 286 (3): 441-455.

APE2 promotes DNA damage response pathway from a single-strand break., Lin Y, Bai L, Cupello S, Hossain MA, Deem B, McLeod M, Raj J, Yan S., Nucleic Acids Res. March 16, 2018; 46 (5): 2479-2494.                

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome., Jenness C, Giunta S, Müller MM, Kimura H, Muir TW, Funabiki H., Proc Natl Acad Sci U S A. January 30, 2018; 115 (5): E876-E885.                                

MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication., Kumagai A, Dunphy WG., Mol Biol Cell. November 1, 2017; 28 (22): 2998-3012.              

Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses., Choi SH, Yoo HY., Biochem Biophys Res Commun. October 7, 2016; 479 (1): 5-11.

Xenopus Mcm10 is a CDK-substrate required for replication fork stability., Chadha GS, Gambus A, Gillespie PJ, Blow JJ., Cell Cycle. August 17, 2016; 15 (16): 2183-2195.            

Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage., Acevedo J, Yan S, Michael WM., J Biol Chem. June 17, 2016; 291 (25): 13124-31.

REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts., DeStephanis D, McLeod M, Yan S., Biochem Biophys Res Commun. May 8, 2015; 460 (3): 609-15.

Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database., Wühr M, Freeman RM, Presler M, Horb ME, Peshkin L, Gygi S, Kirschner MW., Curr Biol. July 7, 2014; 24 (13): 1467-1475.          

Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts., Bai L, Michael WM, Yan S., Cell Signal. May 1, 2014; 26 (5): 857-67.

Titration of four replication factors is essential for the Xenopus laevis midblastula transition., Collart C, Allen GE, Bradshaw CR, Smith JC, Zegerman P., Science. August 23, 2013; 341 (6148): 893-6.

Efficient initiation of DNA replication in eukaryotes requires Dpb11/TopBP1-GINS interaction., Tanaka S, Komeda Y, Umemori T, Kubota Y, Takisawa H, Araki H., Mol Cell Biol. July 1, 2013; 33 (13): 2614-22.

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks., Lee J, Dunphy WG., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.          

A role for the MRN complex in ATR activation via TOPBP1 recruitment., Duursma AM, Driscoll R, Elias JE, Cimprich KA., Mol Cell. April 11, 2013; 50 (1): 116-22.

WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling., Yan S, Willis J., Biochem Biophys Res Commun. February 15, 2013; 431 (3): 466-71.

The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif., Ohlenschläger O, Kuhnert A, Schneider A, Haumann S, Bellstedt P, Keller H, Saluz HP, Hortschansky P, Hänel F, Grosse F, Görlach M, Pospiech H., Nucleic Acids Res. September 1, 2012; 40 (17): 8309-24.              

Treslin, DUE-B, and GEMC1 cannot complement Sld3 mutants in fission yeast., Wang Z, Kim E, Leffak M, Xu YJ, Xu YJ., FEMS Yeast Res. June 1, 2012; 12 (4): 486-90.

Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts., Kumar S, Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell Cycle. March 15, 2012; 11 (6): 1183-94.

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication., Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., J Cell Biol. June 13, 2011; 193 (6): 995-1007.                

CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts., Ramírez-Lugo JS, Yoo HY, Yoon SJ, Dunphy WG., Cell Cycle. February 1, 2011; 10 (3): 469-80.

GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication., Piergiovanni G, Costanzo V., Cell Cycle. September 15, 2010; 9 (18): 3662-6.

GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication., Balestrini A, Cosentino C, Errico A, Garner E, Costanzo V., Nat Cell Biol. May 1, 2010; 12 (5): 484-91.        

Continued primer synthesis at stalled replication forks contributes to checkpoint activation., Van C, Yan S, Michael WM, Waga S, Cimprich KA., J Cell Biol. April 19, 2010; 189 (2): 233-46.              

Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks., Lee J, Lee J, Dunphy WG., Mol Biol Cell. March 15, 2010; 21 (6): 926-35.            

Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM., Wawrousek KE, Fortini BK, Polaczek P, Chen L, Liu Q, Dunphy WG, Campbell JL., Cell Cycle. March 15, 2010; 9 (6): 1156-66.

The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation., Chowdhury A, Liu G, Kemp M, Chen X, Katrangi N, Myers S, Ghosh M, Yao J, Gao Y, Bubulya P, Leffak M., Mol Cell Biol. March 1, 2010; 30 (6): 1495-507.

Treslin collaborates with TopBP1 in triggering the initiation of DNA replication., Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Cell. February 5, 2010; 140 (3): 349-59.                        

Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion., Errico A, Cosentino C, Rivera T, Losada A, Schwob E, Hunt T, Costanzo V., EMBO J. December 2, 2009; 28 (23): 3681-92.              

The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Mol Biol Cell. May 1, 2009; 20 (9): 2351-60.

TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks., Yan S, Michael WM., J Cell Biol. March 23, 2009; 184 (6): 793-804.            

Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein., Schmidt U, Wollmann Y, Franke C, Grosse F, Saluz HP, Hänel F., Biochem J. January 1, 2008; 409 (1): 169-77.

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR., Lee J, Lee J, Kumagai A, Dunphy WG., J Biol Chem. September 21, 2007; 282 (38): 28036-44.

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM., Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., J Biol Chem. June 15, 2007; 282 (24): 17501-6.

The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1., Hashimoto Y, Tsujimura T, Sugino A, Takisawa H., Genes Cells. September 1, 2006; 11 (9): 993-1007.

The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication., Matsuno K, Kumano M, Kubota Y, Hashimoto Y, Takisawa H., Mol Cell Biol. July 1, 2006; 26 (13): 4843-52.                

The DNA polymerase activity of Pol epsilon holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts., Shikata K, Sasa-Masuda T, Okuno Y, Waga S, Sugino A., BMC Biochem. May 1, 2006; 7 21.            

Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling., Yan S, Lindsay HD, Michael WM., J Cell Biol. April 24, 2006; 173 (2): 181-6.          

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