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Summary Expression Phenotypes Gene Literature (78) GO Terms (14) Nucleotides (227) Proteins (56) Interactants (303) Wiki
XB-GENEPAGE-999034

Papers associated with furin



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R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient., Lee H, Lee H, Camuto CM, Niehrs C., Nat Commun. February 2, 2024; 15 (1): 1003.                                                                  

SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans., DeGroot MS, Williams B, Chang TY, Maas Gamboa ML, Larus IM, Hong G, Fromme JC, Liu J., PLoS Biol. August 1, 2023; 21 (8): e3002272.                        

Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd., Lee H, Lee H, Sun R, Niehrs C., J Biol Chem. February 1, 2022; 298 (2): 101586.                

Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with the vertebrate terrestrial migration., Wang XP, Balchak DM, Gentilcore C, Clark NL, Kashlan OB., Elife. January 5, 2022; 11         

Regulation of epithelial sodium channel activity by SARS-CoV-1 and SARS-CoV-2 proteins., Grant SN, Lester HA., Biophys J. July 20, 2021; 120 (14): 2805-2813.

A novel class III endogenous retrovirus with a class I envelope gene in African frogs with an intact genome and developmentally regulated transcripts in Xenopus tropicalis., Yedavalli VRK, Patil A, Parrish J, Kozak CA., Retrovirology. July 14, 2021; 18 (1): 20.              

Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification., Reis AH, Sokol SY., Sci Rep. June 28, 2021; 11 (1): 13433.            

Pinhead antagonizes Admp to promote notochord formation., Itoh K, Ossipova O, Sokol SY., iScience. May 7, 2021; 24 (6): 102520.                            

R-spondins are BMP receptor antagonists in Xenopus early embryonic development., Lee H, Lee H, Seidl C, Sun R, Glinka A, Niehrs C., Nat Commun. November 4, 2020; 11 (1): 5570.                                            

Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels., Zhao R, Ali G, Nie HG, Chang Y, Bhattarai D, Su X, Zhao X, Matthay MA, Ji HL., Br J Pharmacol. July 1, 2020; 177 (13): 3091-3106.

The N terminus of α-ENaC mediates ENaC cleavage and activation by furin., Kota P, Gentzsch M, Dang YL, Boucher RC, Stutts MJ., J Gen Physiol. August 6, 2018; 150 (8): 1179-1187.              

Incorporation of the δ-subunit into the epithelial sodium channel (ENaC) generates protease-resistant ENaCs in Xenopus laevis., Wichmann L, Vowinkel KS, Perniss A, Manzini I, Althaus M., J Biol Chem. May 4, 2018; 293 (18): 6647-6658.

The NOTCH signaling pathway in normal and malignant blood cell production., Suresh S, Irvine AE., J Cell Commun Signal. March 1, 2015; 9 (1): 5-13.      

Determination of Alkali-Sensing Parts of the Insulin Receptor-Related Receptor Using the Bioinformatic Approach., Deyev IE, Popova NV, Petrenko AG., Acta Naturae. January 1, 2015; 7 (2): 80-6.      

Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease., Carattino MD, Mueller GM, Palmer LG, Frindt G, Rued AC, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. November 1, 2014; 307 (9): F1080-7.

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength., de Lau W, Peng WC, Gros P, Clevers H., Genes Dev. February 15, 2014; 28 (4): 305-16.          

Crystal structures of Lgr4 and its complex with R-spondin1., Xu K, Xu Y, Xu Y, Rajashankar KR, Robev D, Nikolov DB., Structure. September 3, 2013; 21 (9): 1683-9.

Characterization of the molecular structure, expression and bioactivity of the TNFSF13B (BAFF) gene of the South African clawed frog, Xenopus laevis., Yang L, Zhou L, Zong X, Cao X, Ji X, Gu W, Zhang S., Int Immunopharmacol. March 1, 2013; 15 (3): 478-87.

Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel., Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C., J Gen Physiol. October 1, 2012; 140 (4): 375-89.                      

Tissue kallikrein activation of the epithelial Na channel., Patel AB, Chao J, Palmer LG., Am J Physiol Renal Physiol. August 15, 2012; 303 (4): F540-50.

Energetic and structural basis for activation of the epithelial sodium channel by matriptase., Kota P, García-Caballero A, Dang H, Gentzsch M, Stutts MJ, Dokholyan NV., Biochemistry. April 24, 2012; 51 (16): 3460-9.

TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site., Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. January 1, 2012; 302 (1): F1-8.

A homolog of Subtilisin-like Proprotein Convertase 7 is essential to anterior neural development in Xenopus., Senturker S, Thomas JT, Mateshaytis J, Moos M., PLoS One. January 1, 2012; 7 (6): e39380.                

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling., Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM, Niehrs C., EMBO Rep. September 30, 2011; 12 (10): 1055-61.

Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel., Passero CJ, Carattino MD, Kashlan OB, Myerburg MM, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. October 1, 2010; 299 (4): F854-61.

E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta., Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B., J Clin Invest. July 1, 2010; 120 (7): 2474-85.

Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines., Song W, Wei S, Zhou Y, Lazrak A, Liu G, Londino JD, Squadrito GL, Matalon S., J Biol Chem. March 26, 2010; 285 (13): 9716-9728.

The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo., Ho DM, Yeo CY, Whitman M., Mech Dev. January 1, 2010; 127 (9-12): 485-95.                  

Alternative mechanism of activation of the epithelial na+ channel by cleavage., Hu JC, Bengrine A, Lis A, Awayda MS., J Biol Chem. December 25, 2009; 284 (52): 36334-36345.

Site-specific cleavage of BMP4 by furin, PC6, and PC7., Nelsen SM, Christian JL., J Biol Chem. October 2, 2009; 284 (40): 27157-66.

Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences., Kudo H, Liu J, Jansen EJ, Ozawa A, Panula P, Martens GJ, Lindberg I., Endocrinology. March 1, 2009; 150 (3): 1393-9.

Genome-wide identification of Xenopus matrix metalloproteinases: conservation and unique duplications in amphibians., Fu L, Das B, Mathew S, Shi YB., BMC Genomics. February 17, 2009; 10 81.                  

Plasmin activates epithelial Na+ channels by cleaving the gamma subunit., Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR., J Biol Chem. December 26, 2008; 283 (52): 36586-91.

Single-channel analysis of functional epithelial sodium channel (ENaC) stability at the apical membrane of A6 distal kidney cells., Yu L, Helms MN, Yue Q, Eaton DC., Am J Physiol Renal Physiol. November 1, 2008; 295 (5): F1519-27.

Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels., Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C., J Physiol. October 1, 2008; 586 (19): 4587-608.

Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation., Carattino MD, Hughey RP, Kleyman TR., J Biol Chem. September 12, 2008; 283 (37): 25290-25295.

Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins., Tonge D, Chan K, Zhu N, Panjwani A, Arno M, Lynham S, Ward M, Snape A, Pizzey J., J Cell Sci. August 1, 2008; 121 (Pt 15): 2565-77.                        

Small molecule activator of the human epithelial sodium channel., Lu M, Echeverri F, Kalabat D, Laita B, Dahan DS, Smith RD, Xu H, Staszewski L, Yamamoto J, Ling J, Hwang N, Kimmich R, Li P, Patron E, Keung W, Patron A, Moyer BD., J Biol Chem. May 2, 2008; 283 (18): 11981-94.

Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: role of furin-mediated endogenous proteolysis., Harris M, Garcia-Caballero A, Stutts MJ, Firsov D, Rossier BC., J Biol Chem. March 21, 2008; 283 (12): 7455-63.

Identification of a novel pool of extracellular pro-myostatin in skeletal muscle., Anderson SB, Goldberg AL, Whitman M., J Biol Chem. March 14, 2008; 283 (11): 7027-35.

Defining an inhibitory domain in the alpha-subunit of the epithelial sodium channel., Carattino MD, Passero CJ, Steren CA, Maarouf AB, Pilewski JM, Myerburg MM, Hughey RP, Kleyman TR., Am J Physiol Renal Physiol. January 1, 2008; 294 (1): F47-52.

Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development., Andersson O, Bertolino P, Ibáñez CF., Dev Biol. November 15, 2007; 311 (2): 500-11.

Vg1 has specific processing requirements that restrict its action to body axis patterning centers., Thomas JT, Moos M., Dev Biol. October 1, 2007; 310 (1): 129-39.          

Glycoproteins of the vitelline envelope of Amphibian oocyte: biological and molecular characterization of ZPC component (gp41) in Bufo arenarum., Barisone GA, Krapf D, Correa-Fiz F, Arranz SE, Cabada MO., Mol Reprod Dev. May 1, 2007; 74 (5): 629-40.

Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit., Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, Kleyman TR., J Biol Chem. March 2, 2007; 282 (9): 6153-60.

Xenopus fibrillin regulates directed convergence and extension., Skoglund P, Keller R., Dev Biol. January 15, 2007; 301 (2): 404-16.              

Regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain., Sopory S, Nelsen SM, Degnin C, Wong C, Christian JL., J Biol Chem. November 10, 2006; 281 (45): 34021-31.

Subtilisin-like proprotein convertase activity is necessary for left-right axis determination in Xenopus neurula embryos., Toyoizumi R, Takeuchi S, Mogi K., Dev Genes Evol. October 1, 2006; 216 (10): 607-22.

CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces., Thomas JT, Prakash D, Weih K, Moos M., J Biol Chem. September 8, 2006; 281 (36): 26725-33.              

The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit., Carattino MD, Sheng S, Bruns JB, Pilewski JM, Hughey RP, Kleyman TR., J Biol Chem. July 7, 2006; 281 (27): 18901-7.

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