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Summary Expression Phenotypes Gene Literature (119) GO Terms (17) Nucleotides (259) Proteins (55) Interactants (404) Wiki
XB-GENEPAGE-999973

Papers associated with mcm2



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Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication., Coxon A, Maundrell K, Kearsey SE., Nucleic Acids Res. November 11, 1992; 20 (21): 5571-7.

A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication., Starborg M, Brundell E, Gell K, Larsson C, White I, Daneholt B, Höög C., J Cell Sci. March 1, 1995; 108 ( Pt 3) 927-34.

MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells., Madine MA, Khoo CY, Mills AD, Laskey RA., Nature. June 1, 1995; 375 (6530): 421-4.

The possible involvement of replication-related proteins with a DEAD-box-like motif in cell-free DNA replication of Xenopus eggs., Someya A, Shioda M., Biochem Biophys Res Commun. July 26, 1995; 212 (3): 1098-106.

The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts., Madine MA, Khoo CY, Mills AD, Musahl C, Laskey RA., Curr Biol. November 1, 1995; 5 (11): 1270-9.

Identification of two Xenopus laevis genes, xMCM2 and xCDC46, with sequence homology to MCM genes involved in DNA replication., Miyake S, Saito I, Kobayashi H, Yamashita S., Gene. October 10, 1996; 175 (1-2): 71-5.

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast., Donovan S, Harwood J, Drury LS, Diffley JF., Proc Natl Acad Sci U S A. May 27, 1997; 94 (11): 5611-6.

The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides., Thömmes P, Kubota Y, Takisawa H, Blow JJ., EMBO J. June 2, 1997; 16 (11): 3312-9.

Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7., Sato N, Arai K, Masai H., EMBO J. July 16, 1997; 16 (14): 4340-51.

Developmental regulation of MCM replication factors in Xenopus laevis., Sible JC, Erikson E, Hendrickson M, Maller JL, Gautier J., Curr Biol. March 12, 1998; 8 (6): 347-50.

Evidence for different MCM subcomplexes with differential binding to chromatin in Xenopus., Coué M, Amariglio F, Maiorano D, Bocquet S, Méchali M., Exp Cell Res. December 15, 1998; 245 (2): 282-9.

Mcm2, but not RPA, is a component of the mammalian early G1-phase prereplication complex., Dimitrova DS, Todorov IT, Melendy T, Gilbert DM., J Cell Biol. August 23, 1999; 146 (4): 709-22.                    

MCM proteins are associated with RNA polymerase II holoenzyme., Yankulov K, Todorov I, Romanowski P, Licatalosi D, Cilli K, McCracken S, Laskey R, Bentley DL., Mol Cell Biol. September 1, 1999; 19 (9): 6154-63.

The spatial position and replication timing of chromosomal domains are both established in early G1 phase., Dimitrova DS, Gilbert DM., Mol Cell. December 1, 1999; 4 (6): 983-93.

The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins., Sun W, Hola M, Pedley K, Tada S, Blow JJ, Todorov IT, Kearsey SE, Brooks RF., J Cell Sci. February 1, 2000; 113 ( Pt 4) 683-95.

Stepwise regulated chromatin assembly of MCM2-7 proteins., Maiorano D, Lemaître JM, Méchali M., J Biol Chem. March 24, 2000; 275 (12): 8426-31.

The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells., Madine MA, Swietlik M, Pelizon C, Romanowski P, Mills AD, Laskey RA., J Struct Biol. April 1, 2000; 129 (2-3): 198-210.

XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis., Maiorano D, Moreau J, Méchali M., Nature. April 6, 2000; 404 (6778): 622-5.

Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex., Pereverzeva I, Whitmire E, Khan B, Coué M., Mol Cell Biol. May 1, 2000; 20 (10): 3667-76.

Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins., Gillespie PJ, Li A, Blow JJ., BMC Biochem. January 1, 2001; 2 15.                

Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45., Wohlschlegel JA, Dhar SK, Prokhorova TA, Dutta A, Walter JC., Mol Cell. February 1, 2002; 9 (2): 233-40.

Identification of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae., Devault A, Vallen EA, Yuan T, Green S, Bensimon A, Schwob E., Curr Biol. April 16, 2002; 12 (8): 689-94.

Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import., Hodgson B, Li A, Tada S, Blow JJ., Curr Biol. April 16, 2002; 12 (8): 678-83.

MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts., Edwards MC, Tutter AV, Cvetic C, Gilbert CH, Prokhorova TA, Walter JC., J Biol Chem. September 6, 2002; 277 (36): 33049-57.

Protein phosphatase 2A regulates binding of Cdc45 to the prereplication complex., Chou DM, Petersen P, Walter JC, Walter G., J Biol Chem. October 25, 2002; 277 (43): 40520-7.

The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication., Van Hatten RA, Tutter AV, Holway AH, Khederian AM, Walter JC, Michael WM., J Cell Biol. November 25, 2002; 159 (4): 541-7.          

Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding., Gregan J, Lindner K, Brimage L, Franklin R, Namdar M, Hart EA, Aves SJ, Kearsey SE., Mol Biol Cell. September 1, 2003; 14 (9): 3876-87.

Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination., Li A, Blow JJ., Nat Cell Biol. March 1, 2004; 6 (3): 260-7.

The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation., Oehlmann M, Score AJ, Blow JJ., J Cell Biol. April 26, 2004; 165 (2): 181-90.                  

A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition., Saxena S, Yuan P, Dhar SK, Senga T, Takeda D, Robinson H, Kornbluth S, Swaminathan K, Dutta A., Mol Cell. July 23, 2004; 15 (2): 245-58.

A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replication., Pacek M, Walter JC., EMBO J. September 15, 2004; 23 (18): 3667-76.

Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex., Takahashi TS, Yiu P, Chou MF, Gygi S, Walter JC., Nat Cell Biol. October 1, 2004; 6 (10): 991-6.

DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process., Shechter D, Ying CY, Gautier J., J Biol Chem. October 29, 2004; 279 (44): 45586-93.

DNA replication licensing in somatic and germ cells., Eward KL, Obermann EC, Shreeram S, Loddo M, Fanshawe T, Williams C, Jung HI, Prevost AT, Blow JJ, Stoeber K, Williams GH., J Cell Sci. November 15, 2004; 117 (Pt 24): 5875-86.

Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses., Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG., J Biol Chem. December 17, 2004; 279 (51): 53353-64.

Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts., Arias EE, Walter JC., Genes Dev. January 1, 2005; 19 (1): 114-26.

Functional domains of the Xenopus replication licensing factor Cdt1., Ferenbach A, Li A, Brito-Martins M, Blow JJ., Nucleic Acids Res. January 12, 2005; 33 (1): 316-24.              

Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts., Maiorano D, Krasinska L, Lutzmann M, Mechali M., Curr Biol. January 26, 2005; 15 (2): 146-53.

Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus., Li A, Blow JJ., EMBO J. January 26, 2005; 24 (2): 395-404.

Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts., Tsuyama T, Tada S, Watanabe S, Seki M, Enomoto T., Nucleic Acids Res. February 1, 2005; 33 (2): 765-75.            

MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation., Maiorano D, Cuvier O, Danis E, Méchali M., Cell. February 11, 2005; 120 (3): 315-28.

Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family., Lutzmann M, Maiorano D, Méchali M., Gene. December 5, 2005; 362 51-6.

The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding., Ying CY, Gautier J., EMBO J. December 21, 2005; 24 (24): 4334-44.

Regulation of replication licensing by acetyltransferase Hbo1., Iizuka M, Matsui T, Takisawa H, Smith MM., Mol Cell Biol. February 1, 2006; 26 (3): 1098-108.

Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F., Hayashi R, Goto Y, Haga A, Kobayashi D, Ikeda R, Yoshida K., Gene. February 15, 2006; 367 126-34.

Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication., Pacek M, Tutter AV, Kubota Y, Takisawa H, Walter JC., Mol Cell. February 17, 2006; 21 (4): 581-7.

Dynamics of DNA binding of replication initiation proteins during de novo formation of pre-replicative complexes in Xenopus egg extracts., Waga S, Zembutsu A., J Biol Chem. April 21, 2006; 281 (16): 10926-34.

Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress., Woodward AM, Göhler T, Luciani MG, Oehlmann M, Ge X, Gartner A, Jackson DA, Blow JJ., J Cell Biol. June 5, 2006; 173 (5): 673-83.              

Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision., Davidson IF, Li A, Blow JJ., Mol Cell. November 3, 2006; 24 (3): 433-43.              

A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus., Lutzmann M, Maiorano D, Méchali M., EMBO J. December 13, 2006; 25 (24): 5764-74.

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