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Summary Expression Phenotypes Gene Literature (119) GO Terms (17) Nucleotides (259) Proteins (55) Interactants (404) Wiki
XB-GENEPAGE-999973

Papers associated with mcm2



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Mitoxantrone 2HCl's adroit activity against cervical cancer replication and maintenance proteins: a multitargeted approach., Hakami MA, Hazazi A, Alsulami MO, Alsaiari AA., J Biomol Struct Dyn. March 22, 2024; 1-14.

TopBP1 utilises a bipartite GINS binding mode to support genome replication., Day M, Tetik B, Parlak M, Almeida-Hernández Y, Räschle M, Kaschani F, Siegert H, Marko A, Sanchez-Garcia E, Kaiser M, Barker IA, Pearl LH, Oliver AW, Boos D., Nat Commun. February 27, 2024; 15 (1): 1797.              

Overlapping action of T3 and T4 during Xenopus laevis development., Tribondeau A, Du Pasquier D, Benchouaia M, Blugeon C, Buisine N, Sachs LM., Front Endocrinol (Lausanne). January 1, 2024; 15 1360188.      

The structural mechanism of dimeric DONSON in replicative helicase activation., Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A., Mol Cell. November 16, 2023; 83 (22): 4017-4031.e9.                              

DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation., Kingsley G, Skagia A, Passaretti P, Fernandez-Cuesta C, Reynolds-Winczura A, Koscielniak K, Gambus A., Nucleic Acids Res. October 13, 2023; 51 (18): 9748-9763.                  

In silico protein interaction screening uncovers DONSON's role in replication initiation., Lim Y, Tamayo-Orrego L, Schmid E, Tarnauskaite Z, Kochenova OV, Gruar R, Muramatsu S, Lynch L, Schlie AV, Carroll PL, Chistol G, Reijns MAM, Kanemaki MT, Jackson AP, Walter JC., Science. September 22, 2023; 381 (6664): eadi3448.

Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation., Hashimoto Y, Sadano K, Miyata N, Ito H, Tanaka H., EMBO J. September 4, 2023; 42 (17): e114131.                          

RNA localization during early development of the axolotl., Šimková K, Naraine R, Vintr J, Soukup V, Šindelka R., Front Cell Dev Biol. January 1, 2023; 11 1260795.                        

The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair., Semlow DR, MacKrell VA, Walter JC., Nat Struct Mol Biol. May 1, 2022; 29 (5): 451-462.

Multistep mechanism of G-quadruplex resolution during DNA replication., Sato K, Martin-Pintado N, Post H, Altelaar M, Knipscheer P., Sci Adv. September 24, 2021; 7 (39): eabf8653.

Studying chromosome biology with single-molecule resolution in Xenopus laevis egg extracts., Cameron G, Yardimci H., Essays Biochem. April 16, 2021; 65 (1): 17-26.        

Single-strand DNA breaks cause replisome disassembly., Vrtis KB, Dewar JM, Chistol G, Wu RA, Graham TGW, Walter JC., Mol Cell. March 18, 2021; 81 (6): 1309-1318.e6.  

The DNA replication fork suppresses CMG unloading from chromatin before termination., Low E, Chistol G, Zaher MS, Kochenova OV, Walter JC., Genes Dev. November 1, 2020; 34 (21-22): 1534-1545.

RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR., Lyu K, Kumagai A, Dunphy WG., Cell Cycle. April 1, 2019; 18 (8): 898-913.              

TRAIP is a master regulator of DNA interstrand crosslink repair., Wu RA, Semlow DR, Kamimae-Lanning AN, Kochenova OV, Chistol G, Hodskinson MR, Amunugama R, Sparks JL, Wang M, Deng L, Mimoso CA, Low E, Patel KJ, Walter JC., Nature. March 1, 2019; 567 (7747): 267-272.                          

Claspin - checkpoint adaptor and DNA replication factor., Smits VAJ, Cabrera E, Freire R, Gillespie DA., FEBS J. February 1, 2019; 286 (3): 441-455.

The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair., Sparks JL, Chistol G, Gao AO, Räschle M, Larsen NB, Mann M, Duxin JP, Walter JC., Cell. January 10, 2019; 176 (1-2): 167-181.e21.

Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading., Amunugama R, Willcox S, Wu RA, Abdullah UB, El-Sagheer AH, Brown T, McHugh PJ, Griffith JD, Walter JC., Cell Rep. June 19, 2018; 23 (12): 3419-3428.        

The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism., Li H, O'Donnell ME., Bioessays. March 1, 2018; 40 (3):


Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress., Wang F, Zhu S, Fisher LA, Wang W, Oakley GG, Li C, Peng A., Sci Rep. February 8, 2018; 8 (1): 2683.            

Suppression of targeting of Dbf4-dependent kinase to pre-replicative complex in G0 nuclei., Okada T, Okabe G, Tak YS, Mimura S, Takisawa H, Kubota Y., Genes Cells. February 1, 2018; 23 (2): 94-104.

MCM interference during licensing of DNA replication in Xenopus egg extracts-Possible Role of a C-terminal region of MCM3., Mimura S, Kubota Y, Takisawa H., Cell Cycle. January 1, 2018; 17 (4): 492-505.

RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin., Aze A, Fragkos M, Bocquet S, Cau J, Méchali M., Nat Commun. December 14, 2017; 8 (1): 2130.            

Phosphorylation Dynamics Dominate the Regulated Proteome during Early Xenopus Development., Peuchen EH, Cox OF, Sun L, Hebert AS, Coon JJ, Champion MM, Dovichi NJ, Huber PW., Sci Rep. November 15, 2017; 7 (1): 15647.                          

MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication., Kumagai A, Dunphy WG., Mol Biol Cell. November 1, 2017; 28 (22): 2998-3012.              

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines., Gardner NJ, Gillespie PJ, Carrington JT, Shanks EJ, McElroy SP, Haagensen EJ, Frearson JA, Woodland A, Blow JJ., Cell Chem Biol. August 17, 2017; 24 (8): 981-992.e4.                        

An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7., Perez-Arnaiz P, Bruck I, Colbert MK, Kaplan DL., Nucleic Acids Res. July 7, 2017; 45 (12): 7261-7275.                

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1., Alver RC, Chadha GS, Gillespie PJ, Blow JJ., Cell Rep. March 7, 2017; 18 (10): 2508-2520.                

Rethinking origin licensing., Bell SP., Elife. January 19, 2017; 6   

p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair., Fullbright G, Rycenga HB, Gruber JD, Long DT., Mol Cell Biol. November 14, 2016; 36 (23): 2983-2994.

Xenopus Mcm10 is a CDK-substrate required for replication fork stability., Chadha GS, Gambus A, Gillespie PJ, Blow JJ., Cell Cycle. August 17, 2016; 15 (16): 2183-2195.            

Structure of human Cdc45 and implications for CMG helicase function., Simon AC, Sannino V, Costanzo V, Pellegrini L., Nat Commun. May 18, 2016; 7 11638.                

Exploring the phosphoproteome profiles during Xenopus egg activation by calcium stimulation using a fully automated phosphopeptide purification system., Kanno T, Furukawa K, Horigome T., J Biochem. April 1, 2016; 159 (4): 407-19.

The mechanism of DNA replication termination in vertebrates., Dewar JM, Budzowska M, Walter JC., Nature. September 17, 2015; 525 (7569): 345-50.                            

Prediction of Functionally Important Phospho-Regulatory Events in Xenopus laevis Oocytes., Johnson JR, Santos SD, Johnson T, Pieper U, Strumillo M, Wagih O, Sali A, Krogan NJ, Beltrao P., PLoS Comput Biol. August 27, 2015; 11 (8): e1004362.                            

Protein phosphatase 2A and Cdc7 kinase regulate the DNA unwinding element-binding protein in replication initiation., Gao Y, Yao J, Poudel S, Romer E, Abu-Niaaj L, Leffak M., J Biol Chem. December 26, 2014; 289 (52): 35987-6000.

NCOA4 transcriptional coactivator inhibits activation of DNA replication origins., Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F., Mol Cell. July 3, 2014; 55 (1): 123-37.

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts., Gaggioli V, Le Viet B, Germe T, Hyrien O., Nucleic Acids Res. August 1, 2013; 41 (15): 7313-31.                

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks., Lee J, Dunphy WG., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.          

The dimeric Mcm8-9 complex of Xenopus laevis likely has a conserved function for resistance to DNA damage., Kanemaki MT., Cell Cycle. May 1, 2013; 12 (9): 1338-9.  

Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation., Gambus A, Blow JJ., Cell Cycle. April 15, 2013; 12 (8): 1225-32.                

Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos., Kisielewska J, Blow JJ., Development. January 1, 2012; 139 (1): 63-74.              

Evolutionary diversification of eukaryotic DNA replication machinery., Aves SJ, Liu Y, Richards TA., Subcell Biochem. January 1, 2012; 62 19-35.

Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor., Hara M, Abe Y, Tanaka T, Yamamoto T, Okumura E, Kishimoto T., Nat Commun. January 1, 2012; 3 1059.              

Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression., Hartford SA, Luo Y, Southard TL, Min IM, Lis JT, Schimenti JC., Proc Natl Acad Sci U S A. October 25, 2011; 108 (43): 17702-7.

Roles of histone chaperone CIA/Asf1 in nascent DNA elongation during nucleosome replication., Ishikawa K, Ohsumi T, Tada S, Natsume R, Kundu LR, Nozaki N, Senda T, Enomoto T, Horikoshi M, Seki M., Genes Cells. October 1, 2011; 16 (10): 1050-62.  

Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase., Fu YV, Yardimci H, Long DT, Ho TV, Guainazzi A, Bermudez VP, Hurwitz J, van Oijen A, Schärer OD, Walter JC., Cell. September 16, 2011; 146 (6): 931-41.

Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression., Gosnell JA, Christensen TW., BMC Mol Biol. April 6, 2011; 12 13.            

MCM2-7 form double hexamers at licensed origins in Xenopus egg extract., Gambus A, Khoudoli GA, Jones RC, Blow JJ., J Biol Chem. April 1, 2011; 286 (13): 11855-64.                

MCM-BP regulates unloading of the MCM2-7 helicase in late S phase., Nishiyama A, Frappier L, Méchali M., Genes Dev. January 15, 2011; 25 (2): 165-75.

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