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Summary Expression Phenotypes Gene Literature (92) GO Terms (4) Nucleotides (93) Proteins (30) Interactants (383) Wiki
XB--482110

Papers associated with pkd2



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5 paper(s) referencing morpholinos

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Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates., Szenker-Ravi E, Ott T, Khatoo M, de Bellaing AM, Goh WX, Chong YL, Beckers A, Kannesan D, Louvel G, Anujan P, Ravi V, Bonnard C, Moutton S, Schoen P, Fradin M, Colin E, Megarbane A, Daou L, Chehab G, Di Filippo S, Rooryck C, Deleuze JF, Boland A, Arribard N, Eker R, Tohari S, Ng AY, Rio M, Lim CT, Eisenhaber B, Eisenhaber F, Venkatesh B, Amiel J, Crollius HR, Gordon CT, Gossler A, Roy S, Attie-Bitach T, Blum M, Bouvagnet P, Reversade B., Nat Genet. January 1, 2022; 54 (1): 62-72.

Aquatic models of human ciliary diseases., Corkins ME, Krneta-Stankic V, Kloc M, Miller RK., Genesis. January 1, 2021; 59 (1-2): e23410.          

Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus animal cap upon activin treatment., Satou-Kobayashi Y, Kim JD, Fukamizu A, Asashima M., Sci Rep. January 1, 2021; 11 (1): 14537.          

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts., Grosch M, Brunner K, Ilyaskin AV, Schober M, Staudner T, Schmied D, Stumpp T, Schmidt KN, Madej MG, Pessoa TD, Othmen H, Kubitza M, Osten L, de Vries U, Mair MM, Somlo S, Moser M, Kunzelmann K, Ziegler C, Haerteis S, Korbmacher C, Witzgall R., J Cell Sci. January 1, 2021; 134 (16):                 

Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5., Maerker M, Getwan M, Dowdle ME, McSheene JC, Gonzalez V, Pelliccia JL, Hamilton DS, Yartseva V, Vejnar C, Tingler M, Minegishi K, Vick P, Giraldez AJ, Hamada H, Burdine RD, Sheets MD, Blum M, Schweickert A., Nat Commun. January 1, 2021; 12 (1): 5482.                              

Deep learning is widely applicable to phenotyping embryonic development and disease., Naert T, Çiçek Ö, Ogar P, Bürgi M, Shaidani NI, Kaminski MM, Xu Y, Grand K, Vujanovic M, Prata D, Hildebrandt F, Brox T, Ronneberger O, Voigt FF, Helmchen F, Loffing J, Horb ME, Willsey HR, Lienkamp SS., Development. January 1, 2021; 148 (21):                                                                 

Comparative gene expression profiling between optic nerve and spinal cord injury in Xenopus laevis reveals a core set of genes inherent in successful regeneration of vertebrate central nervous system axons., Belrose JL, Prasad A, Sammons MA, Gibbs KM, Szaro BG., BMC Genomics. August 5, 2020; 21 (1): 540.                  

Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos., Naert T, Tulkens D, Edwards NA, Carron M, Shaidani NI, Wlizla M, Boel A, Demuynck S, Horb ME, Coucke P, Willaert A, Zorn AM, Vleminckx K, Vleminckx K., Sci Rep. January 1, 2020; 10 (1): 14662.                      

A dual function of FGF signaling in Xenopus left-right axis formation., Schneider I, Kreis J, Schweickert A, Blum M, Vick P., Development. January 1, 2019; 146 (9):                               

Mechanical strain, novel genes and evolutionary insights: news from the frog left-right organizer., Blum M, Ott T., Curr Opin Genet Dev. January 1, 2019; 56 8-14.      

Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals., Gentsch GE, Spruce T, Owens NDL, Smith JC., Nat Commun. January 1, 2019; 10 (1): 4269.                                        

An Optimized Screen Reduces the Number of GA Transporters and Provides Insights Into Nitrate Transporter 1/Peptide Transporter Family Substrate Determinants., Wulff N, Ernst HA, Jørgensen ME, Lambertz S, Maierhofer T, Belew ZM, Crocoll C, Motawia MS, Geiger D, Jørgensen FS, Mirza O, Nour-Eldin HH., Front Plant Sci. January 1, 2019; 10 1106.                    

Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians., Néant I, Leung HC, Webb SE, Miller AL, Miller AL, Moreau M, Leclerc C., Sci Rep. January 1, 2019; 9 (1): 16049.                                    

A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site., Kashyap P, Ng C, Wang Z, Li B, Arif Pavel M, Martin H, Yu Y., Biochem Biophys Res Commun. January 1, 2019; 512 (4): 812-818.            

The ion channel function of polycystin-1 in the polycystin-1/polycystin-2 complex., Wang Z, Ng C, Liu X, Wang Y, Li B, Kashyap P, Chaudhry HA, Castro A, Kalontar EM, Ilyayev L, Walker R, Alexander RT, Qian F, Chen XZ, Yu Y., EMBO Rep. January 1, 2019; 20 (11): e48336.                            

AtOPT6 Protein Functions in Long-Distance Transport of Glutathione in Arabidopsis thaliana., Wongkaew A, Asayama K, Kitaiwa T, Nakamura SI, Kojima K, Stacey G, Sekimoto H, Yokoyama T, Ohkama-Ohtsu N., Plant Cell Physiol. July 1, 2018; 59 (7): 1443-1451.

An Early Function of Polycystin-2 for Left-Right Organizer Induction in Xenopus., Vick P, Kreis J, Schneider I, Tingler M, Getwan M, Thumberger T, Beyer T, Schweickert A, Blum M., iScience. April 27, 2018; 2 76-85.                                        

Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney., Zhang B, Tran U, Wessely O., Development. January 1, 2018; 145 (6):                         

Premotor Neuron Divergence Reflects Vocal Evolution., Barkan CL, Kelley DB, Zornik E., J Neurosci. January 1, 2018; 38 (23): 5325-5337.              

PLC and IP3-evoked Ca2+ release initiate the fast block to polyspermy in Xenopus laevis eggs., Wozniak KL, Tembo M, Phelps WA, Lee MT, Carlson AE., J Gen Physiol. January 1, 2018; 150 (9): 1239-1248.            

Characterization of potential TRPP2 regulating proteins in early Xenopus embryos., Futel M, Le Bouffant R, Buisson I, Umbhauer M, Riou JF., J Cell Biochem. January 1, 2018; 119 (12): 10338-10350.  

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels., Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkley D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ., Nat Commun. January 1, 2018; 9 (1): 2302.            

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2., Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, Fatehi M, Liu X, Hussein S, Kong T, Li J, Light PE, Tang J, Flockerzi V, Tsiokas L, Chen XZ., Cell Rep. January 1, 2018; 22 (6): 1560-1573.          

The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex., Feng S, Streets AJ, Nesin V, Tran U, Nie H, Onopiuk M, Wessely O, Tsiokas L, Ong ACM., J Am Soc Nephrol. October 1, 2017; 28 (10): 2973-2984.

Using Xenopus to study genetic kidney diseases., Lienkamp SS., Semin Cell Dev Biol. March 1, 2016; 51 117-24.    

Retigabine holds KV7 channels open and stabilizes the resting potential., Corbin-Leftwich A, Mossadeq SM, Ha J, Ruchala I, Le AH, Villalba-Galea CA., J Gen Physiol. March 1, 2016; 147 (3): 229-41.            

The polycystin complex mediates Wnt/Ca(2+) signalling., Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai CX, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L., Nat Cell Biol. January 1, 2016; 18 (7): 752-764.              

Hereditary Renal Hypouricemia Type 1 and Autosomal Dominant Polycystic Kidney Disease., Stiburkova B, Stekrova J, Nakamura M, Ichida K., Am J Med Sci. October 1, 2015; 350 (4): 268-71.

TRPP2-dependent Ca2+ signaling in dorso-lateral mesoderm is required for kidney field establishment in Xenopus., Futel M, Leclerc C, Le Bouffant R, Buisson I, Néant I, Umbhauer M, Moreau M, Riou JF., J Cell Sci. March 1, 2015; 128 (5): 888-99.                      

The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality., Boskovski MT, Yuan S, Pedersen NB, Goth CK, Makova S, Clausen H, Brueckner M, Khokha MK., Nature. December 19, 2013; 504 (7480): 456-9.    

Left-right asymmetry: lessons from Cancún., Burdine RD, Caspary T., Development. November 1, 2013; 140 (22): 4465-70.    

Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation., Streets AJ, Wessely O, Peters DJ, Ong AC., Hum Mol Genet. May 15, 2013; 22 (10): 1924-39.

Angiogenesis in the intermediate lobe of the pituitary gland alters its structure and function., Tanaka S, Nakakura T, Jansen EJ, Unno K, Okada R, Suzuki M, Martens GJ, Kikuyama S., Gen Comp Endocrinol. May 1, 2013; 185 10-8.        

Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex., Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J., Nat Commun. January 1, 2012; 3 1252.            

α-TC1.9 cells--a model system for analyzing the endoproteolytic processing of POMC., Chen Q, Layton K, Veo K, Angleson JK, Dores RM., Gen Comp Endocrinol. May 15, 2011; 172 (1): 96-106.

Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein., Duning K, Rosenbusch D, Schlüter MA, Tian Y, Kunzelmann K, Meyer N, Schulze U, Markoff A, Pavenstädt H, Weide T., J Biol Chem. October 29, 2010; 285 (44): 33584-8.

V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cells., Jansen EJ, Hafmans TG, Martens GJ., Mol Biol Cell. October 1, 2010; 21 (19): 3330-9.                

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1., Woodward OM, Li Y, Yu S, Yu S, Greenwell P, Wodarczyk C, Boletta A, Guggino WB, Qian F., PLoS One. August 23, 2010; 5 (8): e12305.              

The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity., Tran U, Zakin L, Schweickert A, Agrawal R, Döger R, Blum M, De Robertis EM, Wessely O., Development. April 1, 2010; 137 (7): 1107-16.              

Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease., Li Y, Santoso NG, Yu S, Yu S, Woodward OM, Qian F, Guggino WB., J Biol Chem. December 25, 2009; 284 (52): 36431-36441.

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex., Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff EY, Yang J., Proc Natl Acad Sci U S A. July 14, 2009; 106 (28): 11558-63.

TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum., Wegierski T, Steffl D, Kopp C, Tauber R, Buchholz B, Nitschke R, Kuehn EW, Walz G, Köttgen M., EMBO J. March 4, 2009; 28 (5): 490-9.

Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences., Kudo H, Liu J, Jansen EJ, Ozawa A, Panula P, Martens GJ, Lindberg I., Endocrinology. March 1, 2009; 150 (3): 1393-9.

Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants., Sullivan-Brown J, Schottenfeld J, Okabe N, Hostetter CL, Serluca FC, Thiberge SY, Burdine RD., Dev Biol. February 15, 2008; 314 (2): 261-75.

Cilia-driven leftward flow determines laterality in Xenopus., Schweickert A, Weber T, Beyer T, Vick P, Bogusch S, Feistel K, Blum M., Curr Biol. January 9, 2007; 17 (1): 60-6.        

Inhibition of polycystin-L channel by the Chinese herb Sparganum stoloniferum Buch.-Ham., Li F, Dai XQ, Li Q, Wu Y, Chen XZ., Can J Physiol Pharmacol. August 1, 2006; 84 (8-9): 923-7.

Polycystic kidney disease and receptor for egg jelly is a plasma membrane protein of mouse sperm head., Butscheid Y, Chubanov V, Steger K, Meyer D, Dietrich A, Gudermann T., Mol Reprod Dev. March 1, 2006; 73 (3): 350-60.

ScOPT1 and AtOPT4 function as proton-coupled oligopeptide transporters with broad but distinct substrate specificities., Osawa H, Stacey G, Gassmann W., Biochem J. January 1, 2006; 393 (Pt 1): 267-75.

Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling., Li Y, Wright JM, Qian F, Germino GG, Guggino WB., J Biol Chem. December 16, 2005; 280 (50): 41298-306.

Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer''s vesicle are required for specification of the zebrafish left-right axis., Bisgrove BW, Snarr BS, Emrazian A, Yost HJ., Dev Biol. November 15, 2005; 287 (2): 274-88.

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