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Summary Expression Phenotypes Gene Literature (41) GO Terms (25) Nucleotides (129) Proteins (45) Interactants (553) Wiki
XB--490623

Papers associated with brca1



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TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality., Xiao M, Tang R, Pan H, Yang J, Tong X, Xu H, Guo Y, Lei Y, Wu D, Lei Y, Han Y, Ma Z, Wang W, Xu J, Yu X, Shi S., Gut. February 6, 2025; 74 (3): 410-423.   


Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration., Moulin C, Dvoriantchikova G, Bineshfar N, Swingle B, Martinez G, Groso D, Zhang M, Ivanov D, Pelaez D., Sci Rep. November 9, 2024; 14 (1): 27412.   


PARP1-dependent DNA-protein crosslink repair., Fábián Z, Kakulidis ES, Hendriks IA, Kühbacher U, Larsen NB, Oliva-Santiago M, Wang J, Leng X, Dirac-Svejstrup AB, Svejstrup JQ, Nielsen ML, Caldecott K, Duxin JP., Nat Commun. August 5, 2024; 15 (1): 6641.   


BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles., Huang LC, McKeown CR, He HY, Ta AC, Cline HT., Proc Natl Acad Sci U S A. January 16, 2024; 121 (3): e2316542121.   


Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51., Heijink AM, Stok C, Porubsky D, Manolika EM, de Kanter JK, Kok YP, Everts M, de Boer HR, Audrey A, Bakker FJ, Wierenga E, Tijsterman M, Guryev V, Spierings DCJ, Knipscheer P, van Boxtel R, Ray Chaudhuri A, Lansdorp PM, van Vugt MATM., Nat Commun. November 7, 2022; 13 (1): 6722.

Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks., Ruis K, Huynh O, Montales K, Barr NA, Michael WM., J Biol Chem. July 1, 2022; 298 (7): 101992.   


Apurinic/Apyrimidinic Endonuclease 2 (APE2): An ancillary enzyme for contextual base excision repair mechanisms to preserve genome stability., Chaudhari S, Ware AP, Jayaram P, Gorthi SP, El-Khamisy SF, Satyamoorthy K., Biochimie. November 1, 2021; 190 70-90.

Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin., Dai L, Dai Y, Han J, Huang Y, Wang L, Huang J, Zhou Z., Mol Cell. July 1, 2021; 81 (13): 2765-2777.e6.   

BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract., Barrows JK, Fullbright G, Long DT., Nucleic Acids Res. April 6, 2021; 49 (6): 3263-3273.   


High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability., Matson DR, Denu RA, Zasadil LM, Burkard ME, Weaver BA, Flynn C, Stukenberg PT., BMC Cancer. February 23, 2021; 21 (1): 186.

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication., Jones MJK, Gelot C, Munk S, Koren A, Kawasoe Y, George KA, Santos RE, Olsen JV, McCarroll SA, Frattini MG, Takahashi TS, Jallepalli PV., Mol Cell. February 4, 2021; 81 (3): 426-441.e8.

Function and molecular mechanisms of APE2 in genome and epigenome integrity., Lin Y, McMahon A, Driscoll G, Bullock S, Zhao J, Yan S., Mutat Res Rev Mutat Res. January 1, 2021; 787 108347.

Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin., Tan W, Murphy VJ, Charron A, van Twest S, Sharp M, Constantinou A, Parker MW, Crismani W, Bythell-Douglas R, Deans AJ., PLoS One. February 24, 2020; 15 (2): e0229000.   


Characteristics of in Vivo Model Systems for Ovarian Cancer Studies., Tudrej P, Kujawa KA, Cortez AJ, Lisowska KM., Diagnostics (Basel). September 14, 2019; 9 (3):   


TRAIP is a master regulator of DNA interstrand crosslink repair., Wu RA, Semlow DR, Kamimae-Lanning AN, Kochenova OV, Chistol G, Hodskinson MR, Amunugama R, Sparks JL, Wang M, Deng L, Mimoso CA, Low E, Patel KJ, Walter JC., Nature. March 1, 2019; 567 (7747): 267-272.   


Claspin - checkpoint adaptor and DNA replication factor., Smits VAJ, Cabrera E, Freire R, Gillespie DA., FEBS J. February 1, 2019; 286 (3): 441-455.

Opposite T3 Response of ACTG1-FOS Subnetwork Differentiate Tailfin Fate in Xenopus Tadpole and Post-hatching Axolotl., Kerdivel G, Blugeon C, Fund C, Rigolet M, Sachs LM, Buisine N., Front Endocrinol (Lausanne). January 1, 2019; 10 194.   


Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining., Zhu S, Fisher LA, Bessho T, Peng A., Nucleic Acids Res. October 13, 2017; 45 (18): 10583-10594.   


Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors., Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ, Lienkamp SS., Nat Cell Biol. December 1, 2016; 18 (12): 1269-1280.   


p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair., Fullbright G, Rycenga HB, Gruber JD, Long DT., Mol Cell Biol. November 14, 2016; 36 (23): 2983-2994.

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts., Aparicio T, Baer R, Gottesman M, Gautier J., J Cell Biol. February 15, 2016; 212 (4): 399-408.   


Studying essential DNA metabolism proteins in Xenopus egg extract., Sannino V, Kolinjivadi AM, Baldi G, Costanzo V., Int J Dev Biol. January 1, 2016; 60 (7-8-9): 221-227.

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres., Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M., EMBO J. February 3, 2015; 34 (3): 410-24.   


BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork., Long DT, Joukov V, Budzowska M, Walter JC., Mol Cell. October 2, 2014; 56 (1): 174-85.

BRCA1 is a histone-H2A-specific ubiquitin ligase., Kalb R, Mallery DL, Larkin C, Huang JT, Hiom K., Cell Rep. August 21, 2014; 8 (4): 999-1005.   


DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation., Simsek D, Brunet E, Wong SY, Katyal S, Gao Y, McKinnon PJ, Lou J, Zhang L, Li J, Rebar EJ, Gregory PD, Holmes MC, Jasin M., PLoS Genet. June 1, 2011; 7 (6): e1002080.   


Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair., Simsek D, Furda A, Gao Y, Artus J, Brunet E, Hadjantonakis AK, Van Houten B, Shuman S, McKinnon PJ, Jasin M., Nature. March 10, 2011; 471 (7337): 245-8.

PIASy mediates SUMO-2/3 conjugation of poly(ADP-ribose) polymerase 1 (PARP1) on mitotic chromosomes., Ryu H, Al-Ani G, Deckert K, Kirkpatrick D, Gygi SP, Dasso M, Azuma Y., J Biol Chem. May 7, 2010; 285 (19): 14415-23.

Learning about cancer from frogs: analysis of mitotic spindles in Xenopus egg extracts., Cross MK, Powers MA., Dis Model Mech. January 1, 2009; 2 (11-12): 541-7.   


Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites., Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G., J Mol Biol. August 29, 2008; 381 (2): 361-72.

BRCA1 regulates gamma-tubulin binding to centrosomes., Sankaran S, Crone DE, Palazzo RE, Parvin JD., Cancer Biol Ther. December 1, 2007; 6 (12): 1853-7.

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly., Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM., Cell. November 3, 2006; 127 (3): 539-52.

A mitotic role for BRCA1/BARD1 in tumor suppression?, Clarke PR, Sanderson HS., Cell. November 3, 2006; 127 (3): 453-5.

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures., Yoo HY, Jeong SY, Dunphy WG., Genes Dev. April 1, 2006; 20 (7): 772-83.

Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral., Tavtigian SV, Deffenbaugh AM, Yin L, Judkins T, Scholl T, Samollow PB, de Silva D, Zharkikh A, Thomas A., J Med Genet. April 1, 2006; 43 (4): 295-305.

Analysis of missense variation in human BRCA1 in the context of interspecific sequence variation., Abkevich V, Zharkikh A, Deffenbaugh AM, Frank D, Chen Y, Shattuck D, Skolnick MH, Gutin A, Tavtigian SV., J Med Genet. July 1, 2004; 41 (7): 492-507.

BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition., Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T., J Biol Chem. May 7, 2004; 279 (19): 19643-8.

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation., Lin SY, Li K, Stewart GS, Elledge SJ., Proc Natl Acad Sci U S A. April 27, 2004; 101 (17): 6484-9.

The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties., Fraga MF, Ballestar E, Montoya G, Taysavang P, Wade PA, Esteller M., Nucleic Acids Res. March 15, 2003; 31 (6): 1765-74.

The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication., Van Hatten RA, Tutter AV, Holway AH, Khederian AM, Walter JC, Michael WM., J Cell Biol. November 25, 2002; 159 (4): 541-7.   


Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development., Joukov V, Chen J, Fox EA, Green JB, Livingston DM., Proc Natl Acad Sci U S A. October 9, 2001; 98 (21): 12078-83.   

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