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Summary Expression Phenotypes Gene Literature (125) GO Terms (5) Nucleotides (96) Proteins (31) Interactants (63) Wiki
XB--977698

Papers associated with asic1

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Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a., Bychkov M, Shulepko M, Osmakov D, Andreev Y, Sudarikova A, Vasileva V, Pavlyukov MS, Latyshev YA, Potapov AA, Kirpichnikov M, Shenkarev ZO, Lyukmanova E., Cancers (Basel). July 8, 2020; 12 (7):                       


Mechanism and site of action of big dynorphin on ASIC1a., Borg CB, Braun N, Heusser SA, Bay Y, Weis D, Galleano I, Lund C, Tian W, Haugaard-Kedström LM, Bennett EP, Lynagh T, Strømgaard K, Andersen J, Pless SA., Proc Natl Acad Sci U S A. January 1, 2020; 117 (13): 7447-7454.


Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors., Florentino IF, Silva DPB, Cardoso CS, Menegatti R, de Carvalho FS, Lião LM, Pinto PM, Peigneur S, Costa EA, Tytgat J., Biomed Pharmacother. July 1, 2019; 115 108915.


Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system., Ilyaskin AV, Sure F, Nesterov V, Haerteis S, Korbmacher C., J Gen Physiol. January 1, 2019; 151 (6): 820-833.                    


A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels., Wu Y, Chen Z, Canessa CM., Elife. January 1, 2019; 8               


Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands., Barth D, Fronius M., Sci Rep. January 1, 2019; 9 (1): 6781.                  


The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analogues., Cristofori-Armstrong B, Saez NJ, Chassagnon IR, King GF, Rash LD., Biochem Pharmacol. January 1, 2019; 163 381-390.


Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline., Osmakov DI, Koshelev SG, Lyukmanova EN, Shulepko MA, Andreev YA, Illes P, Kozlov SA., Biomolecules. January 1, 2019; 9 (8):                   


Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides., Bargeton B, Iwaszkiewicz J, Bonifacio G, Roy S, Zoete V, Kellenberger S., Sci Rep. January 1, 2019; 9 (1): 2599.            


Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties., Osmakov DI, Koshelev SG, Palikov VA, Palikova YA, Shaykhutdinova ER, Dyachenko IA, Andreev YA, Kozlov SA., Toxins (Basel). January 1, 2019; 11 (9):         


Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain., Lee JYP, Saez NJ, Cristofori-Armstrong B, Anangi R, King GF, Smith MT, Rash LD., Br J Pharmacol. January 1, 2018; 175 (12): 2204-2218.


Proton-independent activation of acid-sensing ion channel 3 by an alkaloid, lindoldhamine, from Laurus nobilis., Osmakov DI, Koshelev SG, Andreev YA, Dubinnyi MA, Kublitski VS, Efremov RG, Sobolevsky AI, Kozlov SA., Br J Pharmacol. January 1, 2018; 175 (6): 924-937.


Inhalational anesthetics accelerate desensitization of acid-sensing ion channels., Lehmke L, Coburn M, Möller M, Blaumeiser-Debarry R, Lenzig P, Wiemuth D, Gründer S., Neuropharmacology. January 1, 2018; 135 496-505.


New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels., Kalina R, Gladkikh I, Dmitrenok P, Chernikov O, Koshelev S, Kvetkina A, Kozlov S, Kozlovskaya E, Monastyrnaya M., Peptides. January 1, 2018; 104 41-49.


Molecular basis of inhibition of acid sensing ion channel 1A by diminazene., Krauson AJ, Rooney JG, Carattino MD., PLoS One. January 1, 2018; 13 (5): e0196894.          


Thumb domains of the three epithelial Na+ channel subunits have distinct functions., Sheng S, Chen J, Mukherjee A, Yates ME, Buck TM, Brodsky JL, Tolino MA, Hughey RP, Kleyman TR., J Biol Chem. January 1, 2018; 293 (45): 17582-17592.  


The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel., Stephan G, Huang L, Tang Y, Vilotti S, Fabbretti E, Yu Y, Nörenberg W, Franke H, Gölöncsér F, Sperlágh B, Dopychai A, Hausmann R, Schmalzing G, Rubini P, Illes P., Nat Commun. January 1, 2018; 9 (1): 1354.                    


The Conorfamide RPRFa Stabilizes the Open Conformation of Acid-Sensing Ion Channel 3 via the Nonproton Ligand-Sensing Domain., Reiners M, Margreiter MA, Oslender-Bujotzek A, Rossetti G, Gründer S, Schmidt A., Mol Pharmacol. January 1, 2018; 94 (4): 1114-1124.


Functional features of the "finger" domain of the DEG/ENaC channels MEC-4 and UNC-8., Matthewman C, Johnson CK, Miller DM, Bianchi L., Am J Physiol Cell Physiol. January 1, 2018; 315 (2): C155-C163.          


Dimerization of the voltage-sensing phosphatase controls its voltage-sensing and catalytic activity., Rayaprolu V, Royal P, Stengel K, Sandoz G, Kohout SC., J Gen Physiol. January 1, 2018; 150 (5): 683-696.                        


Determinants of selective ion permeation in the epithelial Na+ channel., Yang L, Palmer LG., J Gen Physiol. January 1, 2018; 150 (10): 1397-1407.                            


Screening of 109 neuropeptides on ASICs reveals no direct agonists and dynorphin A, YFMRFamide and endomorphin-1 as modulators., Vyvers A, Schmidt A, Wiemuth D, Gründer S., Sci Rep. January 1, 2018; 8 (1): 18000.                        


Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1., Er SY, Cristofori-Armstrong B, Escoubas P, Rash LD., Neuropharmacology. December 1, 2017; 127 185-195.


Pharmacological modulation of Acid-Sensing Ion Channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ)., Besson T, Lingueglia E, Salinas M., Neuropharmacology. October 1, 2017; 125 429-440.


An implantable ENG detector with in-system velocity selective recording (VSR) capability., Clarke C, Rieger R, Schuettler M, Donaldson N, Taylor J., Med Biol Eng Comput. June 1, 2017; 55 (6): 885-895.


Bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel (ASIC1a)., Ilyaskin AV, Diakov A, Korbmacher C, Haerteis S., Physiol Rep. February 1, 2017; 5 (3):             


A selectivity filter at the intracellular end of the acid-sensing ion channel pore., Lynagh T, Flood E, Boiteux C, Wulf M, Komnatnyy VV, Colding JM, Allen TW, Pless SA., Elife. January 1, 2017; 6                   


Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen., Lynagh T, Romero-Rojo JL, Lund C, Pless SA., J Med Chem. January 1, 2017; 60 (19): 8192-8200.


Diminazene Is a Slow Pore Blocker of Acid-Sensing Ion Channel 1a (ASIC1a)., Schmidt A, Rossetti G, Joussen S, Gründer S., Mol Pharmacol. January 1, 2017; 92 (6): 665-675.


The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide., Yang XN, Niu YY, Liu Y, Yang Y, Wang J, Cheng XY, Liang H, Wang HS, Hu YM, Lu XY, Zhu MX, Xu TL, Tian Y, Yu Y., J Biol Chem. January 1, 2017; 292 (52): 21662-21675.


Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels., Matthewman C, Miller-Fleming TW, Miller DM, Bianchi L., Am J Physiol Cell Physiol. December 1, 2016; 311 (6): C920-C930.


Optogenetic approaches addressing extracellular modulation of neural excitability., Ferenczi EA, Vierock J, Atsuta-Tsunoda K, Tsunoda SP, Ramakrishnan C, Gorini C, Thompson K, Lee SY, Berndt A, Perry C, Minniberger S, Vogt A, Mattis J, Prakash R, Delp S, Deisseroth K, Hegemann P., Sci Rep. September 28, 2016; 6 23947.                


The Thumb Domain Mediates Acid-sensing Ion Channel Desensitization., Krauson AJ, Carattino MD., J Biol Chem. May 20, 2016; 291 (21): 11407-19.


Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain., Diochot S, Alloui A, Rodrigues P, Dauvois M, Friend V, Aissouni Y, Eschalier A, Lingueglia E, Baron A., Pain. March 1, 2016; 157 (3): 552-559.


Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition., Mourier G, Salinas M, Kessler P, Stura EA, Leblanc M, Tepshi L, Besson T, Diochot S, Baron A, Douguet D, Lingueglia E, Servent D., J Biol Chem. February 5, 2016; 291 (6): 2616-29.


Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1., Joeres N, Augustinowski K, Neuhof A, Assmann M, Gründer S., Sci Rep. January 1, 2016; 6 27647.              


Activation of the Human Epithelial Sodium Channel (ENaC) by Bile Acids Involves the Degenerin Site., Ilyaskin AV, Diakov A, Korbmacher C, Haerteis S., J Biol Chem. January 1, 2016; 291 (38): 19835-47.


Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a., Saez NJ, Deplazes E, Cristofori-Armstrong B, Chassagnon IR, Lin X, Mobli M, Mark AE, Rash LD, King GF., Br J Pharmacol. October 1, 2015; 172 (20): 4985-95.


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD., Sci Rep. September 21, 2015; 5 14763.                                


Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a., Gwiazda K, Bonifacio G, Vullo S, Kellenberger S., J Biol Chem. July 17, 2015; 290 (29): 17956-17966.


Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels., Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ., Elife. July 9, 2015; 4 e06774.                


The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface., van Bemmelen MX, Huser D, Gautschi I, Schild L., PLoS One. January 1, 2015; 10 (8): e0135191.              


The comprehensive analysis of DEG/ENaC subunits in Hydra reveals a large variety of peptide-gated channels, potentially involved in neuromuscular transmission., Assmann M, Kuhn A, Dürrnagel S, Holstein TW, Gründer S., BMC Biol. October 14, 2014; 12 84.                      


Intersubunit conformational changes mediate epithelial sodium channel gating., Collier DM, Tomkovicz VR, Peterson ZJ, Benson CJ, Snyder PM., J Gen Physiol. October 1, 2014; 144 (4): 337-48.                    


Ion conduction and selectivity in acid-sensing ion channel 1., Yang L, Palmer LG., J Gen Physiol. September 1, 2014; 144 (3): 245-55.                              


Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry., Bartoi T, Augustinowski K, Polleichtner G, Gründer S, Ulbrich MH., Proc Natl Acad Sci U S A. June 3, 2014; 111 (22): 8281-6.


Protonation controls ASIC1a activity via coordinated movements in multiple domains., Bonifacio G, Lelli CI, Kellenberger S., J Gen Physiol. January 1, 2014; 143 (1): 105-18.                  


The bile acid-sensitive ion channel (BASIC) is activated by alterations of its membrane environment., Schmidt A, Lenzig P, Oslender-Bujotzek A, Kusch J, Lucas SD, Gründer S, Wiemuth D., PLoS One. January 1, 2014; 9 (10): e111549.                    


Independent contribution of extracellular proton binding sites to ASIC1a activation., Krauson AJ, Rued AC, Carattino MD., J Biol Chem. November 29, 2013; 288 (48): 34375-83.


Gating transitions in the palm domain of ASIC1a., Della Vecchia MC, Rued AC, Carattino MD., J Biol Chem. February 22, 2013; 288 (8): 5487-95.

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