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Summary Expression Phenotypes Gene Literature (436) GO Terms (0) Nucleotides (18) Proteins (9) Interactants (232) Wiki
XB--983103

Papers associated with kcnh2

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4 paper(s) referencing morpholinos

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Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 1, 2021;               


Loss-of-function variants in Kv 11.1 cardiac channels as a biomarker for SUDEP., Soh MS, Bagnall RD, Bennett MF, Bleakley LE, Mohamed Syazwan ES, Phillips AM, Chiam MDF, McKenzie CE, Hildebrand M, Crompton D, Bahlo M, Semsarian C, Scheffer IE, Berkovic SF, Reid CA., Ann Clin Transl Neurol. January 1, 2021; 8 (7): 1422-1432.                


GiTx1(β/κ-theraphotoxin-Gi1a), a novel toxin from the venom of Brazilian tarantula Grammostola iheringi (Mygalomorphae, Theraphosidae): Isolation, structural assessments and activity on voltage-gated ion channels., Montandon GG, Cassoli JS, Peigneur S, Verano-Braga T, Santos DMD, Paiva ALB, Moraes ÉR, Kushmerick C, Borges MH, Richardson M, Pimenta AMC, Kjeldsen F, Diniz MRV, Tytgat J, Lima ME., Biochimie. September 1, 2020; 176 138-149.


Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms., Bohannon BM, de la Cruz A, Wu X, Jowais JJ, Perez ME, Dykxhoorn DM, Liin SI, Larsson HP., Elife. January 1, 2020; 9                                                               


Electrophysiological effects of non-vitamin K antagonist oral anticoagulants on atrial repolarizing potassium channels., Wiedmann F, Schlund D, Kraft M, Nietfeld J, Katus HA, Schmidt C, Thomas D., Europace. January 1, 2020; 22 (9): 1409-1418.


The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts., Shi YP, Pang Z, Venkateshappa R, Gunawan M, Kemp J, Truong E, Chang C, Lin E, Shafaattalab S, Faizi S, Rayani K, Tibbits GF, Claydon VE, Claydon TW., Am J Physiol Heart Circ Physiol. January 1, 2020; 319 (2): H251-H261.


Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574., Zangerl-Plessl EM, Berger M, Drescher M, Chen Y, Wu W, Maulide N, Sanguinetti M, Stary-Weinzinger A., J Chem Inf Model. January 1, 2020; 60 (1): 360-371.


Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors., Florentino IF, Silva DPB, Cardoso CS, Menegatti R, de Carvalho FS, Lião LM, Pinto PM, Peigneur S, Costa EA, Tytgat J., Biomed Pharmacother. July 1, 2019; 115 108915.


Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG., Vasseur L, Cens T, Wagner R, Saint N, Kugler V, Chavanieu A, Ouvry C, Dupré C, Ferry G, Boutin JA., Int J Mol Sci. June 28, 2019; 20 (13):           


Fluorescent analogues of BeKm-1 with high and specific activity against the hERG channel., Vasseur L, Chavanieu A, Combemale S, Caumes C, Béroud R, De Waard M, Ducrot P, Boutin JA, Ferry G, Cens T., Toxicon X. April 1, 2019; 2 100010.        


Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice., Li Y, Sun L, Yang T, Jiao W, Tang J, Huang X, Huang Z, Meng Y, Luo L, Wang X, Bian X, Zhang F, Wang K, Sun Q., J Med Chem. January 1, 2019; 62 (1): 159-173.


Bipolar switching by HCN voltage sensor underlies hyperpolarization activation., Cowgill J, Klenchin VA, Alvarez-Baron C, Tewari D, Blair A, Chanda B., Proc Natl Acad Sci U S A. January 1, 2019; 116 (2): 670-678.                        


ANK2 functionally interacts with KCNH2 aggravating long QT syndrome in a double mutation carrier., Gessner G, Runge S, Koenen M, Heinemann SH, Koenen M, Haas J, Meder B, Thomas D, Katus HA, Schweizer PA., Biochem Biophys Res Commun. January 1, 2019; 512 (4): 845-851.


Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels., Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y., Br J Pharmacol. January 1, 2019; 176 (17): 3161-3179.


The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: The role of protein kinase C., Park MH, Park SI, Kim JH, Yu J, Lee EH, Seo SR, Jo SH., Mol Cell Endocrinol. January 1, 2019; 494 110488.


Temperature Dependence of the Biophysical Mechanisms Underlying the Inhibition and Enhancement Effect of Amiodarone on hERG Channels., Lo YC, Kuo CC., Mol Pharmacol. January 1, 2019; 96 (3): 330-344.


A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels., Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ, Baukrowitz T., Science. January 1, 2019; 363 (6429): 875-880.


The molecular determinants of R-roscovitine block of hERG channels., Cernuda B, Fernandes CT, Allam SM, Orzillo M, Suppa G, Chia Chang Z, Athanasopoulos D, Buraei Z., PLoS One. January 1, 2019; 14 (9): e0217733.                      


Regulation of Eag1 gating by its intracellular domains., Whicher JR, MacKinnon R., Elife. January 1, 2019; 8                     


Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds., Hull CM, Genge CE, Hobbs Y, Rayani K, Lin E, Gunawan M, Shafaattalab S, Tibbits GF, Claydon TW., Am J Physiol Regul Integr Comp Physiol. January 1, 2019; 317 (6): R921-R931.


Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels., Wang ZJ, Tiwari PB, Üren A, Brelidze TI., BMC Pharmacol Toxicol. January 1, 2019; 20 (1): 42.                        


Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations., Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y., J Gen Physiol. January 1, 2019; 151 (2): 214-230.                      


Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation., Shi YP, Thouta S, Cheng YM, Claydon TW., J Gen Physiol. January 1, 2019; 151 (2): 231-246.              


Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain., Kume S, Shimomura T, Tateyama M, Kubo Y., J Physiol. January 1, 2018; 596 (19): 4629-4650.


Probing the molecular basis of hERG drug block with unnatural amino acids., Macdonald LC, Kim RY, Kurata HT, Fedida D., Sci Rep. January 1, 2018; 8 (1): 289.              


Nocturnal Atrial Fibrillation Caused by Mutation in KCND2, Encoding Pore-Forming (α) Subunit of the Cardiac Kv4.2 Potassium Channel., Drabkin M, Zilberberg N, Menahem S, Mulla W, Halperin D, Yogev Y, Wormser O, Perez Y, Kadir R, Etzion Y, Katz A, Birk OS., Circ Genom Precis Med. January 1, 2018; 11 (11): e002293.


Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo., Baburin I, Varkevisser R, Schramm A, Saxena P, Beyl S, Szkokan P, Linder T, Stary-Weinzinger A, van der Heyden MAG, Houtman M, Takanari H, Jonsson M, Beekman JHD, Hamburger M, Vos MA, Hering S., Pharmacol Res. January 1, 2018; 131 150-163.


Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain., de la Peña P, Domínguez P, Barros F., Pflugers Arch. January 1, 2018; 470 (7): 1069-1085.                


Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels., Dai G, James ZM, Zagotta WN., J Gen Physiol. January 1, 2018; 150 (4): 625-635.            


Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype., Thouta S, Lo G, Grajauskas L, Claydon T., Sci Rep. January 1, 2018; 8 (1): 4962.        


The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues., Dou Y, Macdonald LC, Wu Y, Fedida D., Biophys J. November 7, 2017; 113 (9): 1979-1991.


APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel KV10.1., Moreels L, Peigneur S, Galan DT, De Pauw E, Béress L, Waelkens E, Pardo LA, Quinton L, Tytgat J., Mar Drugs. September 13, 2017; 15 (9):                 


Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference., Scherer D, Schworm B, Seyler C, Xynogalos P, Scholz EP, Thomas D, Katus HA, Zitron E., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2017; 390 (7): 701-710.


Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3., Gardner A, Wu W, Thomson S, Zangerl-Plessl EM, Stary-Weinzinger A, Sanguinetti MC., Mol Pharmacol. January 1, 2017; 92 (4): 437-450.


hERG Channel Blocking Ipecac Alkaloids Identified by Combined In Silico - In Vitro Screening., Kratz JM, Mair CE, Oettl SK, Saxena P, Scheel O, Schuster D, Hering S, Rollinger JM., Planta Med. July 1, 2016; 82 (11-12): 1009-15.


Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels., Wu W, Gardner A, Sachse FB, Sanguinetti MC., Mol Pharmacol. January 1, 2016; 90 (4): 469-82.


Mitragynine and its potential blocking effects on specific cardiac potassium channels., Tay YL, Teah YF, Chong YM, Jamil MFA, Kollert S, Adenan MI, Wahab HA, Döring F, Wischmeyer E, Tan ML., Toxicol Appl Pharmacol. January 1, 2016; 305 22-39.


Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4., Abbott GW., Sci Rep. January 1, 2016; 6 38412.              


High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance., Steffensen AB, Refaat MM, David JP, Mujezinovic A, Calloe K, Wojciak J, Nussbaum RL, Scheinman MM, Schmitt N., Sci Rep. September 21, 2015; 5 10009.              


Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels., Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD., Sci Rep. September 21, 2015; 5 14763.                                


HPLC-Based Activity Profiling for hERG Channel Inhibitors in the South African Medicinal Plant Galenia africana., Du K, De Mieri M, Saxena P, Phungula KV, Wilhelm A, Hrubaru MM, van Rensburg E, Zietsman PC, Hering S, van der Westhuizen JH, Hamburger M., Planta Med. August 1, 2015; 81 (12-13): 1154-62.


Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states., de la Peña P, Machín A, Fernández-Trillo J, Domínguez P, Barros F., Pflugers Arch. August 1, 2015; 467 (8): 1747-56.


hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala., De Mieri M, Du K, Neuburger M, Saxena P, Zietsman PC, Hering S, van der Westhuizen JH, Hamburger M., J Nat Prod. July 24, 2015; 78 (7): 1697-707.


C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation., Gardner A, Sanguinetti MC., Mol Pharmacol. July 1, 2015; 88 (1): 19-28.


Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements., Grienke U, Mair CE, Saxena P, Baburin I, Scheel O, Ganzera M, Schuster D, Hering S, Rollinger JM., J Agric Food Chem. June 17, 2015; 63 (23): 5634-9.


The Link between Inactivation and High-Affinity Block of hERG1 Channels., Wu W, Gardner A, Sanguinetti MC., Mol Pharmacol. June 1, 2015; 87 (6): 1042-50.


Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains., Lörinczi É, Gómez-Posada JC, de la Peña P, Tomczak AP, Fernández-Trillo J, Leipscher U, Stühmer W, Barros F, Pardo LA., Nat Commun. March 30, 2015; 6 6672.                    


Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways., Goodchild SJ, Macdonald LC, Fedida D., Biophys J. March 24, 2015; 108 (6): 1435-1447.


NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation., Guo J, Cheng YM, Lees-Miller JP, Perissinotti LL, Claydon TW, Hull CM, Thouta S, Roach DE, Durdagi S, Noskov SY, Duff HJ., Biophys J. March 24, 2015; 108 (6): 1400-1413.


Anesthetic drug midazolam inhibits cardiac human ether-à-go-go-related gene channels: mode of action., Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP., Drug Des Devel Ther. January 1, 2015; 9 867-77.              

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