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Summary Expression Phenotypes Gene Literature (59) GO Terms (3) Nucleotides (76) Proteins (30) Interactants (147) Wiki

Papers associated with aopep

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2 paper(s) referencing morpholinos

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Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels., Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S., Elife. January 1, 2020; 9                               

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity., Zhang F, Swartz KJ, Jara-Oseguera A., Elife. January 1, 2019; 8             

Phosphoinositides modulate the voltage dependence of two-pore channel 3., Shimomura T, Kubo Y., J Gen Physiol. January 1, 2019; 151 (8): 986-1006.                              

Functional genomics of epilepsy-associated mutations in the GABAA receptor subunits reveal that one mutation impairs function and two are catastrophic., Absalom NL, Ahring PK, Liao VW, Balle T, Jiang T, Anderson LL, Arnold JC, McGregor IS, Bowen MT, Chebib M., J Biol Chem. January 1, 2019; 294 (15): 6157-6171.                  

The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin., Tian W, Yan P, Xu N, Chakravorty A, Liefke R, Xi Q, Wang Z., Nucleic Acids Res. January 1, 2019; 47 (10): 5436-5448.          

Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor., Basak S, Gicheru Y, Kapoor A, Mayer ML, Filizola M, Chakrapani S., Nat Commun. January 1, 2019; 10 (1): 3225.                                    

SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility., Awadia S, Huq F, Arnold TR, Goicoechea SM, Sun YJ, Hou T, Kreider-Letterman G, Massimi P, Banks L, Fuentes EJ, Miller AL, Miller AL, Garcia-Mata R., J Cell Biol. January 1, 2019; 218 (8): 2699-2725.                                                  

Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization., McCarthy AE, Yoshioka C, Mansoor SE., Cell. January 1, 2019; 179 (3): 659-670.e13.

Cryo-EM structure of 5-HT3A receptor in its resting conformation., Basak S, Gicheru Y, Samanta A, Molugu SK, Huang W, Fuente M, Hughes T, Taylor DJ, Nieman MT, Moiseenkova-Bell V, Chakrapani S., Nat Commun. January 1, 2018; 9 (1): 514.          

A twist defect mechanism for ATP-dependent translocation of nucleosomal DNA., Winger J, Nodelman IM, Levendosky RF, Bowman GD., Elife. January 1, 2018; 7                                   

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels., Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkley D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ., Nat Commun. January 1, 2018; 9 (1): 2302.            

Structural basis of neurosteroid anesthetic action on GABAA receptors., Chen Q, Wells MM, Arjunan P, Tillman TS, Cohen AE, Xu Y, Xu Y, Tang P., Nat Commun. January 1, 2018; 9 (1): 3972.              

Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region., Huo H, Fryatt AG, Farmer LK, Schmid R, Evans RJ., J Biol Chem. January 1, 2018; 293 (33): 12820-12831.                

Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor., Basak S, Gicheru Y, Rao S, Sansom MSP, Chakrapani S., Nature. January 1, 2018; 563 (7730): 270-274.

Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants., Alaimo A, Etxeberria A, Gómez-Posada JC, Gomis-Perez C, Fernández-Orth J, Malo C, Villarroel A., Channels (Austin). January 1, 2018; 12 (1): 299-310.            

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels., Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M., Cell Rep. January 1, 2018; 23 (4): 993-1004.                          

(S)-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu-ACR-16 receptor., Zheng F, Du X, Chou TH, Robertson AP, Yu EW, VanVeller B, Martin RJ., Int J Parasitol Drugs Drug Resist. April 1, 2017; 7 (1): 12-22.              

Polycomb repressive complex 2 in an autoinhibited state., Bratkowski M, Yang X, Liu X., J Biol Chem. January 1, 2017; 292 (32): 13323-13332.

Expression and Purification of the Pain Receptor TRPV1 for Spectroscopic Analysis., Velisetty P, Stein RA, Sierra-Valdez FJ, Vásquez V, Cordero-Morales JF., Sci Rep. January 1, 2017; 7 (1): 9861.                

Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors., Yi F, Mou TC, Dorsett KN, Volkmann RA, Menniti FS, Sprang SR, Hansen KB., Neuron. September 21, 2016; 91 (6): 1316-1329.                

A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia., Tsoi H, Yu AC, Chen ZS, Ng NK, Chan AY, Yuen LY, Abrigo JM, Tsang SY, Tsui SK, Tong TM, Lo IF, Lam ST, Mok VC, Wong LK, Ngo JC, Lau KF, Chan TF, Chan HY., J Med Genet. August 31, 2016; .    

In vivo tracking of histone H3 lysine 9 acetylation in Xenopus laevis during tail regeneration., Suzuki M, Takagi C, Miura S, Sakane Y, Suzuki M, Sakuma T, Sakamoto N, Endo T, Kamei Y, Sato Y, Kimura H, Yamamoto T, Ueno N, Suzuki KT, Suzuki KT., Genes Cells. April 1, 2016; 21 (4): 358-69.                        

Identification and functional characterization of four transient receptor potential ankyrin 1 variants in Apolygus lucorum (Meyer-Dür)., Fu T, Hull JJ, Yang T, Wang G., Insect Mol Biol. January 1, 2016; 25 (4): 370-84.

Investigating the Role of Loop C Hydrophilic Residue ''T244'' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism., Naffaa MM, Absalom N, Solomon VR, Chebib M, Hibbs DE, Hanrahan JR., PLoS One. January 1, 2016; 11 (5): e0156618.                              

Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism., Nolan K, Kattamuri C, Rankin SA, Rankin SA, Read RJ, Zorn AM, Thompson TB., Cell Rep. January 1, 2016; 16 (8): 2077-2086.          

Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine., Nys M, Wijckmans E, Farinha A, Yoluk Ö, Andersson M, Brams M, Spurny R, Peigneur S, Tytgat J, Lindahl E, Ulens C., Proc Natl Acad Sci U S A. January 1, 2016; 113 (43): E6696-E6703.            

Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry., Söderhielm PC, Andersen J, Munro L, Nielsen AT, Kristensen AS., Mol Pharmacol. October 1, 2015; 88 (4): 676-88.

A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation., Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S., J Gen Physiol. October 1, 2015; 146 (4): 323-40.              

Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan., Chang TH, Hsieh FL, Zebisch M, Harlos K, Elegheert J, Jones EY., Elife. July 9, 2015; 4                               

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor., Spurny R, Debaveye S, Farinha A, Veys K, Vos AM, Gossas T, Atack J, Bertrand S, Bertrand D, Danielson UH, Tresadern G, Ulens C., Proc Natl Acad Sci U S A. May 12, 2015; 112 (19): E2543-52.          

Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b., DeBerg HA, Bankston JR, Rosenbaum JC, Brzovic PS, Zagotta WN, Stoll S., Structure. April 7, 2015; 23 (4): 734-44.

Distinct features of cap binding by eIF4E1b proteins., Kubacka D, Miguel RN, Minshall N, Darzynkiewicz E, Standart N, Zuberek J., J Mol Biol. January 30, 2015; 427 (2): 387-405.              

Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain., Findeisen F, Rumpf CH, Minor DL., J Mol Biol. September 9, 2013; 425 (17): 3217-34.

Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration., Love NR, Chen Y, Ishibashi S, Kritsiligkou P, Lea R, Koh Y, Gallop JL, Dorey K, Amaya E., Nat Cell Biol. February 1, 2013; 15 (2): 222-8.        

The Lin28 cold-shock domain remodels pre-let-7 microRNA., Mayr F, Schütz A, Döge N, Heinemann U., Nucleic Acids Res. August 1, 2012; 40 (15): 7492-506.            

Solution structure and fluctuation of the Mg(2+)-bound form of calmodulin C-terminal domain., Ohashi W, Hirota H, Yamazaki T., Protein Sci. April 1, 2011; 20 (4): 690-701.

Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization., Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL., EMBO J. December 1, 2010; 29 (23): 3924-38.

Role of dimer interface in activation and desensitization in AMPA receptors., Gonzalez J, Du M, Parameshwaran K, Suppiramaniam V, Jayaraman V., Proc Natl Acad Sci U S A. May 25, 2010; 107 (21): 9891-6.

Removing the invariant salt bridge of parvalbumin increases flexibility in the AB-loop structure., Hoh F, Cavé A, Strub MP, Banères JL, Padilla A., Acta Crystallogr D Biol Crystallogr. August 1, 2009; 65 (Pt 8): 733-43.

Homologue of mammalian apolipoprotein A-II in non-mammalian vertebrates., Choudhury M, Yamada S, Komatsu M, Kishimura H, Ando S., Acta Biochim Biophys Sin (Shanghai). May 1, 2009; 41 (5): 370-8.

Structural insights into mechanism and specificity of O-GlcNAc transferase., Clarke AJ, Hurtado-Guerrero R, Pathak S, Schüttelkopf AW, Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM., EMBO J. October 22, 2008; 27 (20): 2780-8.        

Duplication and divergence of zebrafish CRALBP genes uncovers novel role for RPE- and Muller-CRALBP in cone vision., Collery R, McLoughlin S, Vendrell V, Finnegan J, Crabb JW, Saari JC, Kennedy BN., Invest Ophthalmol Vis Sci. September 1, 2008; 49 (9): 3812-20.

Quantitative lid dynamics of MDM2 reveals differential ligand binding modes of the p53-binding cleft., Showalter SA, Bruschweiler-Li L, Johnson E, Zhang F, Brüschweiler R., J Am Chem Soc. May 21, 2008; 130 (20): 6472-8.

Zinc regulates the ability of Cdc25C to activate MPF/cdk1., Sun L, Chai Y, Hannigan R, Bhogaraju VK, Machaca K., J Cell Physiol. October 1, 2007; 213 (1): 98-104.

Module structure of interphotoreceptor retinoid-binding protein (IRBP) may provide bases for its complex role in the visual cycle - structure/function study of Xenopus IRBP., Gonzalez-Fernandez F, Baer CA, Ghosh D., BMC Biochem. January 1, 2007; 8 15.                      

Crystal structures of U8 snoRNA decapping nudix hydrolase, X29, and its metal and cap complexes., Scarsdale JN, Peculis BA, Wright HT., Structure. February 1, 2006; 14 (2): 331-43.

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding., Uhrinova S, Uhrin D, Powers H, Watt K, Zheleva D, Fischer P, McInnes C, Barlow PN., J Mol Biol. July 15, 2005; 350 (3): 587-98.

Metamorphic T3-response genes have specific co-regulator requirements., Havis E, Sachs LM, Demeneix BA., EMBO Rep. September 1, 2003; 4 (9): 883-8.

The gastric biology of Helicobacter pylori., Sachs G, Weeks DL, Melchers K, Scott DR., Annu Rev Physiol. January 1, 2003; 65 349-69.

A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin., Wissmann R, Bildl W, Neumann H, Rivard AF, Klöcker N, Weitz D, Schulte U, Adelman JP, Bentrop D, Fakler B., J Biol Chem. February 8, 2002; 277 (6): 4558-64.

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