fbxw7 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-1000485

Gene Symbol: fbxw7 Gene Name: F-box and WD repeat domain containing 7

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: fbxw7 assayed (5 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (61 sources): abnormal Purkinje cell morphology, abnormal T cell activation, abnormal T cell differentiation, abnormal brain development, abnormal brain vasculature morphology, abnormal cerebellar foliation, abnormal cerebellum development, abnormal cerebellum fissure morphology, abnormal cerebral cortex morphology, abnormal cortical intermediate zone morphology, abnormal cortical plate morphology, abnormal embryonic/fetal subventricular zone morphology, abnormal erythrocyte cell number, abnormal heart development, abnormal hematopoietic stem cell physiology, abnormal neuron differentiation, abnormal pulmonary alveolus wall morphology, abnormal somite border morphology, abnormal somite development, abnormal tectum morphology, abnormal vascular development, abnormal vasculogenesis, abnormal vitelline vascular remodeling, arrested T cell differentiation, decreased Purkinje cell number, decreased angiogenesis, decreased bone marrow cell number, decreased double-negative T cell number, decreased embryo size, decreased hematopoietic stem cell number, decreased neuronal precursor cell number, decreased single-positive T cell number, decreased tumor latency, dilated bile duct, disorganized yolk sac vascular plexus, embryo phenotype, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, enlarged thymus, eyelids open at birth, hematopoietic system phenotype, immune system phenotype, impaired lung alveolus development, increased T cell apoptosis, increased T cell derived lymphoma incidence, increased double-positive T cell number, increased lymphoma incidence, lethality, complete penetrance, neonatal lethality, complete penetrance, nervous system phenotype, no abnormal phenotype detected, open neural tube, pale yolk sac, pericardial edema, perinatal lethality, complete penetrance, premature death, prenatal lethality, complete penetrance, small cerebellum, thalamus hypoplasia, thick pulmonary interalveolar septum [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (61 sources): abnormal Purkinje cell morphology, abnormal T cell activation, abnormal T cell differentiation, abnormal brain development, abnormal brain vasculature morphology, abnormal cerebellar foliation, abnormal cerebellum development, abnormal cerebellum fissure morphology, abnormal cerebral cortex morphology, abnormal cortical intermediate zone morphology, [+]