Monarch Ortholog Phenotypes
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Human (10 sources):
Areflexia,
Generalized hypotonia,
Hemolytic anemia,
Hypotonia,
Increased CSF protein concentration,
Limb muscle weakness,
Paralysis,
Paroxysmal nocturnal hemoglobinuria,
Polyneuropathy,
Skeletal muscle atrophy
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Mouse (23 sources):
abnormal CD4-positive, alpha-beta T cell physiology,
abnormal humoral immune response,
abnormal Wallerian degeneration,
choroidal neovascularization,
decreased B cell proliferation,
decreased grip strength,
decreased plasma cell number,
decreased susceptibility to Poxviridae infection,
hemoglobinemia,
increased CD4-positive, alpha beta T cell number,
increased double-positive T cell number,
increased erythrocyte osmotic fragility,
increased macrophage cell number,
increased neutrophil cell number,
increased renal tubule apoptosis,
increased susceptibility to experimental autoimmune encephalomyelitis,
increased susceptibility to experimental autoimmune myasthenia gravis,
increased susceptibility to induced arthritis,
increased susceptibility to injury,
increased susceptibility to kidney reperfusion injury,
increased susceptibility to Orthomyxoviridae infection,
increased susceptibility to weight loss,
increased T cell proliferation
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View all ortholog results at Monarch
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