| Monarch Ortholog Phenotypes
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Human (10 sources):
Areflexia,
Generalized hypotonia,
Hemolytic anemia,
Hypotonia,
Increased CSF protein,
Limb muscle weakness,
Paralysis,
Paroxysmal nocturnal hemoglobinuria,
Polyneuropathy,
Skeletal muscle atrophy
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Mouse (23 sources):
abnormal CD4-positive, alpha-beta T cell physiology,
abnormal Wallerian degeneration,
abnormal humoral immune response,
choroidal neovascularization,
decreased B cell proliferation,
decreased grip strength,
decreased plasma cell number,
decreased susceptibility to Poxviridae infection,
hemoglobinemia,
increased CD4-positive, alpha beta T cell number,
increased T cell proliferation,
increased double-positive T cell number,
increased erythrocyte osmotic fragility,
increased macrophage cell number,
increased neutrophil cell number,
increased renal tubule apoptosis,
increased susceptibility to Orthomyxoviridae infection,
increased susceptibility to experimental autoimmune encephalomyelitis,
increased susceptibility to experimental autoimmune myasthenia gravis,
increased susceptibility to induced arthritis,
increased susceptibility to injury,
increased susceptibility to kidney reperfusion injury,
increased susceptibility to weight loss
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.