plp1 Phenotypes

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Phenotypes

Gene Literature (21)

Nucleotides (420)

Interactants (322)

XB-GENEPAGE-1008579

Gene Symbol: plp1 Gene Name: proteolipid protein 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: plp1 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (72 sources): Abnormal CNS myelination, Abnormal cerebellum morphology, Abnormal pyramidal sign, Abnormality of extrapyramidal motor function, Abnormality of movement, Abnormality of the urinary system, Abnormality of visual evoked potentials, Arteriovenous malformation, Ataxia, Babinski sign, Behavioral abnormality, Bowel incontinence, Cachexia, Cerebral cortical atrophy, Cerebral dysmyelination, Choreoathetosis, Cognitive impairment, Congenital laryngeal stridor, Degeneration of the lateral corticospinal tracts, Delayed speech and language development, Developmental regression, Dysarthria, Dysmetria, Dysphagia, Dystonia, Failure to thrive, Failure to thrive in infancy, Flexion contracture, Gait disturbance, Generalized hypotonia, Global developmental delay, Head titubation, Hearing impairment, Hyperreflexia, Hyporeflexia, Hypotonia, Intellectual disability, Joint stiffness, Kyphosis, Limitation of joint mobility, Lower limb muscle weakness, Lower limb spasticity, Microcephaly, Muscle weakness, Neurological speech impairment, Nystagmus, Optic atrophy, Peripheral neuropathy, Pes cavus, Premature birth, Progressive spastic quadriplegia, Psychomotor deterioration, Pulmonary embolism, Recurrent respiratory infections, Reduction of oligodendroglia, Respiratory insufficiency, Rotary nystagmus, Scanning speech, Scoliosis, Seizure, Sensory neuropathy, Short stature, Skeletal muscle atrophy, Spastic gait, Spastic paraparesis, Spastic paraplegia, Spastic/hyperactive bladder, Spasticity, Spinocerebellar tract degeneration, Sudanophilic leukodystrophy, Tremor, Visual impairment [+]
Mouse (40 sources): abnormal CNS glial cell morphology, abnormal astrocyte morphology, abnormal astrocyte physiology, abnormal axon morphology, abnormal axonal transport, abnormal brain development, abnormal brain white matter morphology, abnormal cell cytoskeleton morphology, abnormal cerebellar granule layer morphology, abnormal cerebellum white matter morphology, abnormal glial cell morphology, abnormal hippocampal fimbria morphology, abnormal locomotor coordination, abnormal microglial cell morphology, abnormal myelin sheath morphology, abnormal oligodendrocyte apoptosis, abnormal optic tract morphology, abnormal startle reflex, asthenozoospermia, axonal spheroids, behavior/neurological phenotype, decreased cholesterol level, decreased locomotor activity, decreased myelin sheath thickness, decreased oligodendrocyte number, decreased susceptibility to Picornaviridae infection, decreased vocalization, delayed eyelid opening, environmentally induced seizures, growth/size/body region phenotype, hindlimb paralysis, increased apoptosis, increased oligodendrocyte number, lethality at weaning, complete penetrance, microgliosis, nervous system phenotype, postnatal lethality, complete penetrance, premature death, reproductive system phenotype, tomacula [+]
View all ortholog results at Monarch