| Monarch Ortholog Phenotypes
|
Human (28 sources):
Anorexia,
Ataxia,
Coma,
Desquamation of skin soon after birth,
Eczematoid dermatitis,
Feeding difficulties in infancy,
Generalized hypotonia,
Global developmental delay,
Growth delay,
Hyperammonemia,
Hyperventilation,
Hypotonia,
Irritability,
Keratoconjunctivitis,
Lethargy,
Metabolic acidosis,
Nausea and vomiting,
Organic aciduria,
Perioral eczema,
Respiratory distress,
Seizure,
Skin rash,
Spasticity,
Tachypnea,
Thrombocytopenia,
Vomiting,
Weight loss,
obsolete Hypotrichosis
[+]
|
|
Mouse (10 sources):
abnormal egg cylinder morphology,
absent head fold,
absent primitive node,
decreased embryo size,
embryonic growth arrest,
embryonic lethality prior to organogenesis,
embryonic lethality, complete penetrance,
failure of primitive streak formation,
failure to gastrulate,
preweaning lethality, complete penetrance
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.