| Monarch Ortholog Phenotypes
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Mouse (36 sources):
abnormal aorta wall morphology,
abnormal circulating alkaline phosphatase level,
abnormal hematocrit,
abnormal hemoglobin content,
abnormal humoral immune response,
abnormal lymphocyte physiology,
abnormal marginal zone B cell physiology,
abnormal systemic arterial blood pressure,
cardiac hypertrophy,
decreased B cell proliferation,
decreased B-1 B cell number,
decreased Ly6C-positive immature NK cell number,
decreased dendritic cell number,
decreased follicular B cell number,
decreased immature NK cell number,
decreased marginal zone B cell number,
decreased memory-marker CD4-positive NK T cell number,
decreased memory-marker gamma-delta T cell number,
decreased physiological sensitivity to xenobiotic,
decreased vasoconstriction,
increased CD4-positive, alpha beta T cell number,
increased CD4-positive, alpha-beta memory T cell number,
increased CD8-positive, alpha-beta memory T cell number,
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
increased KLRG1-positive NK cell number,
increased Ly6C low monocyte number,
increased Ly6C-positive NK T cell number,
increased T cell proliferation,
increased circulating alkaline phosphatase level,
increased effector memory CD8-positive, alpha-beta T cell number,
increased erythrocyte cell number,
increased gamma-delta T cell number,
increased germinal center B cell number,
increased mature NK cell number,
increased plasmacytoid dendritic cell number,
preweaning lethality, incomplete penetrance
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These phenotypes are associated with this gene with a has phenotype relation via Monarch.