| Monarch Ortholog Phenotypes
|
Human (23 sources):
Abnormal circulating fatty-acid concentration,
Agitation,
Cognitive impairment,
Coma,
Decreased circulating vitamin B1 concentration,
Diarrhea,
Drowsiness,
Global developmental delay,
Hepatomegaly,
Hyperhidrosis,
Hyperinsulinemia,
Hyperinsulinemic hypoglycemia,
Hypoketotic hypoglycemia,
Large for gestational age,
Lethargy,
Neonatal hypoglycemia,
Pallor,
Pancreatic islet-cell hyperplasia,
Progressive neurologic deterioration,
Secondary growth hormone deficiency,
Seizure,
Tachycardia,
Vomiting
[+]
|
Mouse (27 sources):
abnormal cellular respiration,
abnormal food intake,
abnormal locomotor behavior,
abnormal macrophage physiology,
abnormal mitochondrial physiology,
abnormal synaptic plasticity,
cellular phenotype,
decreased cellular sensitivity to oxidative stress,
decreased cerebral infarct size,
decreased circulating glucose level,
decreased circulating lactate level,
decreased dopamine level,
decreased mitochondrial fission,
decreased neuron apoptosis,
decreased susceptibility to bacterial infection,
decreased susceptibility to infection induced morbidity/mortality,
decreased susceptibility to ischemic brain injury,
decreased susceptibility to parasitic infection,
growth/size/body region phenotype,
hematopoietic system phenotype,
homeostasis/metabolism phenotype,
impaired righting response,
increased susceptibility to dopaminergic neuron neurotoxicity,
increased thermal nociceptive threshold,
moribund,
respiratory system phenotype,
slow postnatal weight gain
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.