| Monarch Ortholog Phenotypes
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Human (7 sources):
Apnea,
Desquamative interstitial pneumonitis,
Failure to thrive,
Intraalveolar phospholipid accumulation,
Respiratory distress,
Respiratory insufficiency,
Tachypnea
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Mouse (24 sources):
abnormal alveolar lamellar body morphology,
abnormal bronchiole epithelium morphology,
abnormal embryo size,
abnormal lipid homeostasis,
abnormal lung development,
abnormal lung saccule morphology,
abnormal pulmonary alveolus morphology,
abnormal surfactant composition,
abnormal surfactant physiology,
abnormal surfactant secretion,
abnormal type II pneumocyte morphology,
absent alveolar lamellar bodies,
absent type I pneumocytes,
decreased alveolar lamellar body number,
increased wet-to-dry lung weight ratio,
neonatal lethality, complete penetrance,
prenatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance,
primary atelectasis,
pulmonary alveolar hemorrhage,
pulmonary vascular congestion,
renal/urinary system phenotype,
thick lung-associated mesenchyme,
thick pulmonary interalveolar septum
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.