pik3cg Phenotypes

Phenotypes

XB-GENEPAGE-1011008

Gene Symbol: pik3cg Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (35 sources): abnormal cardiac muscle relaxation, abnormal CD8-positive, alpha-beta T cell physiology, abnormal definitive hematopoiesis, abnormal immune cell physiology, abnormal leukocyte physiology, abnormal macrophage physiology, abnormal myocardial fiber morphology, abnormal NK cell differentiation, abnormal response to infection, abnormal T cell activation, abnormal T cell differentiation, abnormal T-helper 2 physiology, decreased CD4-positive, alpha beta T cell number, decreased circulating alanine transaminase level, decreased circulating aspartate transaminase level, decreased cytotoxic T cell cytolysis, decreased interferon-gamma secretion, decreased interleukin-2 secretion, decreased macrophage cell number, decreased platelet calcium level, decreased susceptibility to induced arthritis, decreased susceptibility to induced thrombosis, decreased T cell proliferation, decreased thymocyte number, immune system phenotype, impaired macrophage chemotaxis, impaired neutrophil recruitment, increased cardiac muscle contractility, increased interleukin-1 beta secretion, increased interleukin-6 secretion, increased neutrophil cell number, increased sensitivity to induced morbidity/mortality, increased susceptibility to Poxviridae infection, increased tumor necrosis factor secretion, skin lesions [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (35 sources): abnormal cardiac muscle relaxation, abnormal CD8-positive, alpha-beta T cell physiology, abnormal definitive hematopoiesis, abnormal immune cell physiology, abnormal leukocyte physiology, abnormal macrophage physiology, abnormal myocardial fiber morphology, abnormal NK cell differentiation, abnormal response to infection, abnormal T cell activation, [+]