tcf4 Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (56)

Nucleotides (228)

Interactants (877)

XB-GENEPAGE-1011627

Gene Symbol: tcf4 Gene Name: transcription factor 4

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tcf4 manipulated (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tcf4 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (84 sources): Abnormal autonomic nervous system physiology, Abnormal helix morphology, Abnormal palate morphology, Abnormal pattern of respiration, Absent speech, Acrocyanosis, Aganglionic megacolon, Aggressive behavior, Anteverted nares, Aphasia, Aplasia/Hypoplasia of the corpus callosum, Astigmatism, Ataxia, Autistic behavior, Broad fingertip, Clinodactyly, Clubbing, Coarse facial features, Constipation, Cryptorchidism, Cupped ear, Deeply set eye, Dysphasia, Echolalia, Edema, Encephalopathy, Failure of eruption of permanent teeth, Failure to thrive, Feeding difficulties, Finger clinodactyly, Full cheeks, Gait ataxia, Gastroesophageal reflux, Generalized hypotonia, Global developmental delay, Growth delay, Happy demeanor, Hiatus hernia, Hodgkin lymphoma, Hyperventilation, Hypopigmented skin patches, Hypoplasia of the corpus callosum, Hypotonia, Incoordination, Intellectual disability, Intellectual disability, moderate, Intellectual disability, progressive, Intellectual disability, severe, Intermittent hyperventilation, Microcephaly, Micropenis, Motor delay, Mutism, Myopia, Narrow foot, Narrow forehead, Open mouth, Overhanging nasal tip, Pes planus, Pes valgus, Prominent nasal bridge, Scoliosis, Seizure, Self-injurious behavior, Short metatarsal, Short neck, Short philtrum, Single transverse palmar crease, Sleep apnea, Sleep disturbance, Small cerebral cortex, Small hand, Specific learning disability, Strabismus, Supernumerary nipple, Tapered finger, Thick vermilion border, Thickened helices, Tooth malposition, Triangular nasal tip, Upslanted palpebral fissure, Wide mouth, Wide nasal bridge, Widely spaced teeth [+]
Mouse (37 sources): abnormal T cell differentiation, abnormal action potential, abnormal associative learning, abnormal brain development, abnormal circulating potassium level, abnormal dentate gyrus morphology, abnormal habituation to a new environment, abnormal long term spatial reference memory, abnormal prepulse inhibition, decreased anxiety-related response, decreased brain weight, decreased double-positive T cell number, decreased grip strength, decreased hippocampus volume, decreased prepulse inhibition, decreased pro-B cell number, decreased startle reflex, decreased thymocyte number, decreased vocalization, enhanced NMDA-mediated synaptic currents, enhanced long term potentiation, immune system phenotype, impaired balance, impaired contextual conditioning behavior, impaired cued conditioning behavior, impaired spatial learning, increased double-negative T cell number, increased grooming behavior, increased prepulse inhibition, increased startle reflex, increased thigmotaxis, neonatal lethality, complete penetrance, postnatal lethality, complete penetrance, preweaning lethality, incomplete penetrance, reduced sensorimotor gating, social withdrawal, thin cerebral cortex [+]
View all ortholog results at Monarch