fermt2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-1012565

Gene Symbol: fermt2 Gene Name: FERM domain containing kindlin 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the Meckel's cartilage (2 sources), decreased size of the ceratobranchial I (2 sources), decreased size of the ceratobranchial II (2 sources), decreased size of the ceratobranchial III (2 sources), decreased size of the ceratobranchial IV (2 sources), decreased size of the ceratohyal (2 sources), decreased size of the chondrocranium (2 sources), abnormal cell migration in neural crest (1 source), abnormal development of cardiovascular system (1 source), abnormal development of heart (1 source), abnormal migratory neural crest cell (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

decreased size of the Meckel's cartilage (2 sources), decreased size of the ceratobranchial I (2 sources), decreased size of the ceratobranchial II (2 sources), decreased size of the ceratobranchial III (2 sources), decreased size of the ceratobranchial IV (2 sources), decreased size of the ceratohyal (2 sources), decreased size of the chondrocranium (2 sources), abnormal cell migration in neural crest (1 source), abnormal development of cardiovascular system (1 source), abnormal development of heart (1 source), abnormal migratory neural crest cell (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: fermt2 manipulated (19 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + fermt2 MO (9 sources), Xla Wt + fermt2 MO (7 sources), Xla Wt + chd1 + fermt2 MO + animal cap explant (1 source), Xla Wt + fermt2 (1 source), Xla Wt + fermt2Q614A_W615A-myc (1 source), Xla Wt + wnt3a + fermt2 MO + animal cap explant (1 source), Xtr Wt + fermt2 CRISPR (1 source), Xtr Wt + fermt2 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (32 sources): abnormal cell adhesion, abnormal chondrocyte morphology, abnormal embryonic epiblast morphology, abnormal germ layer development, abnormal limb development, abnormal long bone epiphyseal plate morphology, abnormal long bone epiphyseal plate proliferative zone, abnormal long bone hypertrophic chondrocyte zone, abnormal sternum morphology, absent neurocranium, chondrodystrophy, decreased body size, decreased chondrocyte number, decreased chondrocyte proliferation, decreased femur compact bone thickness, decreased trabecular bone volume, delayed endochondral bone ossification, disorganized long bone epiphyseal plate, embryonic lethality between implantation and somite formation, complete penetrance, endocrine/exocrine gland phenotype, hematoma, increased chondrocyte apoptosis, neonatal lethality, complete penetrance, no abnormal phenotype detected, premature death, short radius, short scapula, skeleton phenotype, small clavicle, small thoracic cage, sternebra fusion, wide sternum [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (32 sources): abnormal cell adhesion, abnormal chondrocyte morphology, abnormal embryonic epiblast morphology, abnormal germ layer development, abnormal limb development, abnormal long bone epiphyseal plate morphology, abnormal long bone epiphyseal plate proliferative zone, abnormal long bone hypertrophic chondrocyte zone, abnormal sternum morphology, absent neurocranium, [+]