epha4 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-1015802

Gene Symbol: epha4 Gene Name: EPH receptor A4

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal eye morphology (7 sources), decreased size of the eye (7 sources), abnormal development of eye (3 sources), decreased size of the lens (3 sources), abnormal lens morphology (2 sources), abnormal retina morphology (2 sources), abnormal development of lens (1 source), abnormal development of retinal layer (1 source), abnormally localised retinal inner nuclear layer (1 source), abnormal retinal pigmented epithelium morphology (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal eye morphology (7 sources), decreased size of the eye (7 sources), abnormal development of eye (3 sources), decreased size of the lens (3 sources), abnormal lens morphology (2 sources), abnormal retina morphology (2 sources), abnormal development of lens (1 source), abnormal development of retinal layer (1 source), abnormally localised retinal inner nuclear layer (1 source), abnormal retinal pigmented epithelium morphology (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: epha4 manipulated (8 sources), epha4 assayed (2 sources)
Computed annotations: epha4 assayed (17 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
cataract 45 (1AP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + epha4 MO (14 sources), Xla Wt + epha4 MO (2 sources), Xla Wt + epha4 MO + sipa1l3 MO (1 source), Xla Wt + nog + epha4 MO + animal cap explant (1 source), Xla Wt + Rno.sipa1l3 + epha4 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (32 sources): abnormal abducens nerve morphology, abnormal anterior commissure pars anterior morphology, abnormal anterior commissure pars posterior morphology, abnormal axon fasciculation, abnormal axon guidance, abnormal axon morphology, abnormal barrel cortex morphology, abnormal central pattern generator function, abnormal innervation, abnormal innervation pattern to muscle, abnormal locomotor activation, abnormal locomotor behavior, abnormal locomotor coordination, abnormal maternal nurturing, abnormal miniature excitatory postsynaptic currents, abnormal motor neuron innervation pattern, abnormal nerve fiber response, abnormal placing response, abnormal primary somatosensory cortex morphology, abnormal spinal cord dorsal column morphology, absent anterior commissure, behavior/neurological phenotype, decreased grip strength, decreased litter size, decreased motor neuron number, ectopic thalamus, impaired limb coordination, limb grasping, nervous system phenotype, no abnormal phenotype detected, reduced long term potentiation, reduced male fertility [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (32 sources): abnormal abducens nerve morphology, abnormal anterior commissure pars anterior morphology, abnormal anterior commissure pars posterior morphology, abnormal axon fasciculation, abnormal axon guidance, abnormal axon morphology, abnormal barrel cortex morphology, abnormal central pattern generator function, abnormal innervation, abnormal innervation pattern to muscle, [+]