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Summary Expression Phenotypes Gene Literature (1873) GO Terms (7) Nucleotides (146) Proteins (49) Interactants (3320) Wiki

tbx2     T-box 2

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased length of anterior-posterior axis (5 sources), abnormal head morphology (2 sources), abnormal tail bud morphology (2 sources), absent head (2 sources), abnormal bending of tail (1 source), abnormal eye (1 source), abnormal gastrulation (1 source), abnormal trunk morphology (1 source), abnormal whole organism (1 source), abnormal whole organism morphology (1 source), abnormally abaxially mislocalized anterior foregut (1 source), abnormally abaxially mislocalized cardiac mesoderm (1 source), abnormally delayed closure of blastopore (1 source), abnormally duplicated cardiac mesoderm (1 source), absent tail bud (1 source), decreased length of tail (1 source), decreased length of trunk (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: tbx2 assayed (5 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + tbx2 MO (4 sources), Xla Wt + tbx20 (3 sources), Xtr Wt + tbx2 MO (3 sources), Xla Wt + tbx20 + animal cap explant (2 sources), Xla Wt + tbx20 (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (33 sources): Abnormal B cell morphology, Atrial septal defect, Autistic behavior, Brachycephaly, Broad nasal tip, Cleft lip, Cleft palate, Cupped ear, Depressed nasal bridge, Depressed nasal tip, [+]
Mouse (14 sources): abnormal cardiovascular development, abnormal fetal atrioventricular canal morphology, abnormal palatal shelf elevation, abnormal truncus arteriosus septation, conotruncal ridge hypoplasia, decreased atrioventricular cushion size, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, increased heart ventricle size, lethality throughout fetal growth and development, complete penetrance, [+]

View all ortholog results at Monarch