| Monarch Ortholog Phenotypes
|
Human (70 sources):
Abnormal B cell count,
Abnormal T cell count,
Abnormal lymphocyte morphology,
Abnormal natural killer cell count,
Abnormality of the face,
Abnormality of the metaphysis,
Anemia,
Aplasia/Hypoplasia of the eyebrow,
Arthritis,
Autoimmune hemolytic anemia,
Autoimmunity,
B lymphocytopenia,
Chronic diarrhea,
Combined immunodeficiency,
Conjunctivitis,
Decreased circulating IgA level,
Decreased circulating IgG level,
Decreased circulating antibody level,
Decreased circulating total IgM,
Decreased lymphocyte proliferation in response to mitogen,
Decreased proportion of CD3-positive T cells,
Desquamation of skin soon after birth,
Diarrhea,
Dry skin,
Edema,
Elevated circulating hepatic transaminase concentration,
Eosinophilia,
Erythroderma,
Failure to thrive,
Failure to thrive secondary to recurrent infections,
Fever,
Hepatomegaly,
Hepatosplenomegaly,
Hypoplasia of the thymus,
Hypoproteinemia,
Hypothyroidism,
Leukocytosis,
Lymphadenitis,
Lymphadenopathy,
Lymphoma,
Lymphopenia,
Mastoiditis,
Meningitis,
Nephrotic syndrome,
Otitis media,
Pallor,
Panhypogammaglobulinemia,
Pneumonia,
Protracted diarrhea,
Pruritus,
Purulent rhinitis,
Recurrent bacterial infections,
Recurrent enteroviral infections,
Recurrent fungal infections,
Recurrent opportunistic infections,
Recurrent respiratory infections,
Recurrent upper and lower respiratory tract infections,
Recurrent viral infections,
Reduced antigen-specific T cell proliferation,
Sepsis,
Severe B lymphocytopenia,
Severe combined immunodeficiency,
Short toe,
Skin rash,
Splenomegaly,
T lymphocytopenia,
Thickened skin,
Thrombocytopenia,
Thyroiditis,
obsolete Hypotrichosis
[+]
|
Mouse (56 sources):
abnormal B cell activation,
abnormal Peyer's patch morphology,
abnormal T cell receptor V(D)J recombination,
abnormal T-helper 1 physiology,
abnormal digestive system morphology,
abnormal double-negative T cell morphology,
abnormal double-positive T cell morphology,
abnormal effector T cell morphology,
abnormal gamma-delta T cell differentiation,
abnormal humoral immune response,
abnormal immune system organ morphology,
abnormal immunoglobulin V(D)J recombination,
abnormal intestinal epithelium morphology,
abnormal intestinal mucosa morphology,
abnormal lymphocyte physiology,
abnormal lymphopoiesis,
abnormal macrophage physiology,
abnormal pre-B cell morphology,
abnormal response to transplant,
abnormal thymus morphology,
absent Hassall's corpuscle,
absent Peyer's patches,
absent immature B cells,
absent mature B cells,
absent pre-B cells,
arrested B cell differentiation,
arrested T cell differentiation,
decreased CD4-positive, alpha beta T cell number,
decreased NK T cell number,
decreased T cell proliferation,
decreased body size,
decreased bone marrow cell number,
decreased double-negative T cell number,
decreased double-positive T cell number,
decreased follicular B cell number,
decreased immature B cell number,
decreased marginal zone B cell number,
decreased mature B cell number,
decreased pre-B cell number,
decreased spleen white pulp amount,
decreased susceptibility to bacterial infection induced morbidity/mortality,
decreased susceptibility to parasitic infection,
decreased susceptibility to type IV hypersensitivity reaction,
decreased thymocyte number,
increased DN3 thymocyte number,
increased double-negative T cell number,
increased granulocyte number,
increased immature B cell number,
increased macrophage cell number,
increased natural killer cell mediated cytotoxicity,
increased plasma cell number,
no abnormal phenotype detected,
small cervical lymph nodes,
small inguinal lymph nodes,
small lymph nodes,
small spleen
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.