smad1 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (242)

XB-GENEPAGE-1018192

Gene Symbol: smad1 Gene Name: SMAD family member 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal bending of tail (1 source), abnormal gastrulation (1 source), abnormal tail morphology (1 source), abnormally delayed closure of blastopore (1 source), absent head (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the embryo (1 source), decreased size of the eye (1 source), decreased size of the head (1 source), edematous ventral trunk (1 source), wholly ventralized embryo (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal bending of tail (1 source), abnormal gastrulation (1 source), abnormal tail morphology (1 source), abnormally delayed closure of blastopore (1 source), absent head (1 source), decreased length of anterior-posterior axis (1 source), decreased size of the embryo (1 source), decreased size of the eye (1 source), decreased size of the head (1 source), edematous ventral trunk (1 source), wholly ventralized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: smad1 manipulated (5 sources), smad1 assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + smad1 MO (6 sources), Xtr Wt + smad1 MO (3 sources), Xtr Wt + smad1-Rno.GR + DEX (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (51 sources): abnormal allantois morphology, abnormal cell morphology, abnormal chorioallantoic fusion, abnormal chorion morphology, abnormal embryo development, abnormal embryo turning, abnormal embryonic epiblast morphology, abnormal extraembryonic ectoderm morphology, abnormal extraembryonic tissue morphology, abnormal gastric chief cell morphology, abnormal gastric parietal cell morphology, abnormal mesenchyme morphology, abnormal mesoderm development, abnormal neurocranium morphology, abnormal placenta morphology, abnormal rostral-caudal axis patterning, abnormal skeleton development, abnormal spinal nerve morphology, abnormal stomach epithelium morphology, abnormal stomach muscularis externa morphology, abnormal ventral body wall morphology, abnormal visceral endoderm morphology, absent primordial germ cells, absent umbilical cord, cardiovascular system phenotype, caudal body truncation, decreased bone trabecula number, decreased embryo size, decreased osteoblast cell number, decreased osteoblast proliferation, decreased primordial germ cell number, decreased trabecular bone connectivity density, decreased trabecular bone thickness, decreased trabecular bone volume, delayed allantois development, delayed bone ossification, disorganized embryonic tissue, disorganized testis cords, distended pericardium, embryonic lethality during organogenesis, complete penetrance, enlarged pericardium, failure of chorioallantoic fusion, impaired osteoblast differentiation, incomplete embryo turning, increased bone trabecular spacing, meteorism, no abnormal phenotype detected, perinatal lethality, incomplete penetrance, postnatal lethality, reduced fertility, rostral body truncation [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (51 sources): abnormal allantois morphology, abnormal cell morphology, abnormal chorioallantoic fusion, abnormal chorion morphology, abnormal embryo development, abnormal embryo turning, abnormal embryonic epiblast morphology, abnormal extraembryonic ectoderm morphology, abnormal extraembryonic tissue morphology, abnormal gastric chief cell morphology, [+]