spi1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-1018246

Gene Symbol: spi1 Gene Name: Spi-1 proto-oncogene

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: spi1 assayed (12 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (72 sources): abnormal T cell differentiation, abnormal T cell subpopulation ratio, abnormal astrocyte morphology, abnormal blood cell morphology/development, abnormal bone marrow cell morphology/development, abnormal bone marrow morphology, abnormal chromosome number, abnormal common myeloid progenitor cell morphology, abnormal definitive hematopoiesis, abnormal double-negative T cell morphology, abnormal embryo size, abnormal erythrocyte cell number, abnormal erythropoiesis, abnormal eye development, abnormal fetal derived definitive erythrocyte cell number, abnormal granulocyte differentiation, abnormal hematopoietic stem cell physiology, abnormal hematopoietic system physiology, abnormal leukopoiesis, abnormal liver size, abnormal macrophage differentiation, abnormal microglial cell morphology, abnormal monocyte morphology, abnormal myelopoiesis, abnormal neutrophil differentiation, abnormal proerythroblast morphology, absent common myeloid progenitor cells, absent erythrocytes, absent mature B cells, arrested B cell differentiation, decreased B-1a cell number, decreased CD4-positive, alpha beta T cell number, decreased body size, decreased double-negative T cell number, decreased double-positive T cell number, decreased granulocyte number, decreased hematocrit, decreased hematopoietic stem cell number, decreased macrophage cell number, decreased mature B cell number, decreased pre-B cell number, decreased pro-B cell number, decreased spleen red pulp amount, decreased thymocyte number, failure of myelopoiesis, hematopoietic system phenotype, homeostasis/metabolism phenotype, impaired myelopoiesis, increased B-1 B cell number, increased B-1b cell number, increased T cell derived lymphoma incidence, increased bone marrow cell number, increased double-negative T cell number, increased granulocyte number, increased hematopoietic stem cell number, increased hematopoietic stem cell proliferation, increased liver weight, increased neutrophil cell number, increased spleen weight, increased tumor incidence, lethality throughout fetal growth and development, complete penetrance, liver hyperplasia, neonatal lethality, complete penetrance, no abnormal phenotype detected, persistence of hyaloid vascular system, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, premature death, prenatal lethality, complete penetrance, preweaning lethality, complete penetrance, small thymus, spleen hyperplasia [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (72 sources): abnormal T cell differentiation, abnormal T cell subpopulation ratio, abnormal astrocyte morphology, abnormal blood cell morphology/development, abnormal bone marrow cell morphology/development, abnormal bone marrow morphology, abnormal chromosome number, abnormal common myeloid progenitor cell morphology, abnormal definitive hematopoiesis, abnormal double-negative T cell morphology, [+]