tcf7l1 Phenotypes

Phenotypes

XB-GENEPAGE-1031984

Gene Symbol: tcf7l1 Gene Name: transcription factor 7 like 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased length of anterior-posterior axis (3 sources), decreased size of the tail (3 sources), increased size of the head (2 sources), abnormal anterior-posterior axis, curved ventral (1 source), decreased size of the head (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tcf7l1 manipulated (13 sources)
Computed annotations: tcf7l1 assayed (3 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tcf7l1 MO (8 sources), Xla Wt + tcf7l1 MO (2 sources), Xla Wt + jmjd6 MO + tcf7l1 MO (1 source), Xla Wt + jmjd6 MO + tcf7l1 MO (1 source), Xla Wt + tcf7l1 (1 source), Xla Wt + tcf7l1 + jmjd6 MO (1 source), Xla Wt + tcf7l1 MO (1 source), Xla Wt + tcf7l1 MO (1 source), Xla Wt + tcf7l1del_970-1653-myc (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (27 sources): abnormal brain development, abnormal eyelid development, abnormal foregut morphology, abnormal limb bud morphology, abnormal limb development, abnormal neural fold formation, abnormal notochord morphology, abnormal primitive streak formation, abnormal rostral-caudal axis patterning, absent heart, absent somites, decreased embryo size, decreased forebrain size, digestive/alimentary phenotype, dilated vasculature, embryonic lethality during organogenesis, complete penetrance, enlarged pericardium, eyelids open at birth, failure of eyelid fusion, increased axial mesoderm size, increased somite number, lethality throughout fetal growth and development, incomplete penetrance, neonatal lethality, complete penetrance, no abnormal phenotype detected, rostral body truncation, rostral-caudal axis duplication, small embryonic telencephalon [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (27 sources): abnormal brain development, abnormal eyelid development, abnormal foregut morphology, abnormal limb bud morphology, abnormal limb development, abnormal neural fold formation, abnormal notochord morphology, abnormal primitive streak formation, abnormal rostral-caudal axis patterning, absent heart, [+]