mapk8 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (164)

XB-GENEPAGE-1217555

Gene Symbol: mapk8 Gene Name: mitogen-activated protein kinase 8

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal development of alimentary system (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: mapk8 manipulated (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + sfrp5 + caHsa.MAPK8 (1 source), Xla Wt + caHsa.MAPK8 + fzd7 MO + DEX (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (42 sources): abnormal T cell activation, abnormal T-helper 1 cell differentiation, abnormal epidermis stratum basale morphology, abnormal fat cell morphology, abnormal myocardium layer morphology, abnormal retina outer nuclear layer morphology, absent keratohyalin granules, cardiac fibrosis, decreased T cell apoptosis, decreased T cell proliferation, decreased body length, decreased cardiac muscle contractility, decreased cardiomyocyte apoptosis, decreased circulating glucose level, decreased circulating growth hormone level, decreased circulating insulin-like growth factor I level, decreased food intake, decreased gonadal fat pad weight, decreased insulin secretion, decreased liver triglyceride level, decreased liver weight, decreased percent body fat/body weight, decreased susceptibility to diet-induced obesity, decreased susceptibility to hepatic steatosis, growth/size/body region phenotype, homeostasis/metabolism phenotype, improved glucose tolerance, increased T cell proliferation, increased b-wave amplitude, increased cardiomyocyte apoptosis, increased circulating adiponectin level, increased epididymal fat pad weight, increased incidence of tumors by chemical induction, increased insulin sensitivity, increased oxygen consumption, increased respiratory quotient, increased response of heart to induced stress, increased retina cone cell number, increased retina rod cell number, liver/biliary system phenotype, thin epidermis, vision/eye phenotype [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (42 sources): abnormal T cell activation, abnormal T-helper 1 cell differentiation, abnormal epidermis stratum basale morphology, abnormal fat cell morphology, abnormal myocardium layer morphology, abnormal retina outer nuclear layer morphology, absent keratohyalin granules, cardiac fibrosis, decreased T cell apoptosis, decreased T cell proliferation, [+]