| Monarch Ortholog Phenotypes
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Human (3 sources):
Increased circulating hemoglobin concentration,
Increased hematocrit,
Polycythemia
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Mouse (32 sources):
abnormal epicardium morphology,
abnormal erythropoiesis,
abnormal heart development,
abnormal interventricular groove morphology,
abnormal myocardial fiber physiology,
abnormal placenta morphology,
decreased angiogenesis,
decreased bone marrow cell number,
decreased erythroblast number,
decreased erythrocyte cell number,
decreased fetal derived definitive erythrocyte cell number,
decreased hematocrit,
decreased hemoglobin content,
decreased oxygen consumption,
embryonic lethality during organogenesis, complete penetrance,
enlarged myocardial fiber,
hemosiderosis,
hyperoxia,
hypoxia,
increased heart right ventricle weight,
increased heart weight,
increased hepatocyte apoptosis,
increased left ventricle weight,
increased pulmonary ventilation,
increased spleen weight,
lethality throughout fetal growth and development, complete penetrance,
no abnormal phenotype detected,
pale liver,
pericardial edema,
small liver,
thick ventricular wall,
ventricular hypoplasia
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.