cdh1 Phenotypes

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Phenotypes

Gene Literature (200)

Nucleotides (130)

Interactants (1155)

XB-GENEPAGE-12531593

Gene Symbol: cdh1 Gene Name: cadherin 1, type 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cell migration in neural crest (3 sources), abnormally increased mobility of non-neural ectoderm (1 source), decreased size of the branchial arch skeleton (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: cdh1 assayed (12 sources)
Computed annotations: cdh1 assayed (4 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + cdh1 MO (4 sources), Xla Wt + cdh1 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (35 sources): Abnormal eyelid morphology, Abnormal hair quantity, Abnormality of metabolism/homeostasis, Abnormality of the orbital region, Abnormality of vision, Anal atresia, Bilateral cleft lip and palate, Breast carcinoma, Carious teeth, Choanal atresia, Chronic atrophic gastritis, Cleft palate, Cleft upper lip, Clinodactyly, Conductive hearing impairment, Conical tooth, Cutaneous syndactyly, Distichiasis, Dysgerminoma, Ectropion of lower eyelids, Endometrial carcinoma, Epidermoid cyst, Euryblepharon, Finger syndactyly, Flat face, High anterior hairline, High forehead, Hypertelorism, Hypodontia, Neoplasm, Neural tube defect, Ovarian papillary adenocarcinoma, Small nail, Sparse hair, Stomach cancer [+]
Mouse (39 sources): abnormal cell adhesion, abnormal embryo development, abnormal embryonic tissue morphology, abnormal enterocyte physiology, abnormal extraembryonic tissue morphology, abnormal mammary gland growth during lactation, abnormal mammary gland growth during pregnancy, abnormal milk composition, abnormal pancreatic islet morphology, abnormal placenta morphology, abnormal placenta physiology, abnormal placental labyrinth vasculature morphology, abnormal preimplantation embryo development, abnormal trophectoderm morphology, abnormal trophoblast layer morphology, absent blastocoele, absent trophectoderm, decreased insulin secretion, decreased placental labyrinth size, embryonic growth arrest, embryonic lethality before implantation, complete penetrance, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, empty decidua capsularis, failure of blastocyst to hatch from the zona pellucida, failure of morula compaction, growth/size/body region phenotype, hypolactation, increased pancreatic beta cell mass, increased pancreatic beta cell proliferation, increased trophectoderm apoptosis, lactation failure, no abnormal phenotype detected, pale yolk sac, placental labyrinth hypoplasia, prenatal lethality, prenatal lethality, complete penetrance, preweaning lethality, complete penetrance [+]
View all ortholog results at Monarch