| Monarch Ortholog Phenotypes
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Human (5 sources):
Hereditary nonpolyposis colorectal carcinoma,
Neoplasm of the stomach,
Renal cell carcinoma,
Transitional cell carcinoma of the bladder,
Uterine leiomyosarcoma
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Mouse (29 sources):
abnormal dorsal aorta morphology,
abnormal endocardium morphology,
abnormal heart development,
abnormal intersomitic vessel morphology,
abnormal pericardial cavity morphology,
abnormal pericyte morphology,
abnormal splenic cell ratio,
abnormal vascular branching morphogenesis,
abnormal vascular development,
abnormal vascular endothelial cell morphology,
abnormal vascular smooth muscle morphology,
abnormal vitelline vascular remodeling,
abnormal vitelline vasculature morphology,
absent atrioventricular cushions,
decreased embryo size,
decreased incidence of tumors by chemical induction,
delayed heart looping,
distended pericardium,
embryonic growth retardation,
embryonic lethality during organogenesis, complete penetrance,
embryonic lethality during organogenesis, incomplete penetrance,
failure of vascular branching,
increased B-2 B cell number,
increased marginal zone B cell number,
increased tumor incidence,
increased vascular endothelial cell number,
no abnormal phenotype detected,
thin myocardium,
vascular smooth muscle hypoplasia
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.