| Monarch Ortholog Phenotypes
|
Human (36 sources):
Abnormal hip bone morphology,
Abnormality of the ear,
Absent phalangeal crease,
Adducted thumb,
Aplasia/Hypoplasia of the radius,
Arthrogryposis multiplex congenita,
Bilateral single transverse palmar creases,
Calcaneovalgus deformity,
Camptodactyly of finger,
Distal arthrogryposis,
Downslanted palpebral fissures,
High palate,
Joint stiffness,
Long philtrum,
Mandibular prognathia,
Metatarsus adductus,
Micrognathia,
Narrow face,
Narrow mouth,
Overlapping fingers,
Prominent nasolabial fold,
Protruding ear,
Rocker bottom foot,
Round ear,
Scoliosis,
Short neck,
Short stature,
Talipes equinovarus,
Tarsal synostosis,
Triangular face,
Ulnar deviation of finger,
Ulnar deviation of the hand or of fingers of the hand,
Ulnar deviation of the wrist,
Vertebral segmentation defect,
Webbed neck,
Wide nasal bridge
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Mouse (21 sources):
abnormal epiphyseal plate morphology,
abnormal forelimb morphology,
abnormal hindlimb morphology,
abnormal long bone epiphyseal plate morphology,
abnormal long bone hypertrophic chondrocyte zone,
decreased angiogenesis,
decreased birth weight,
decreased body size,
decreased bone mineralization,
decreased circulating glucose level,
decreased collagen level,
decreased fasting circulating glucose level,
decreased osteoblast cell number,
decreased osteoblast proliferation,
decreased trabecular bone mass,
decreased width of hypertrophic chondrocyte zone,
delayed endochondral bone ossification,
postnatal lethality, incomplete penetrance,
preweaning lethality, complete penetrance,
short radius,
slow postnatal weight gain
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.