mycn Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (16)

Nucleotides (182)

Interactants (116)

XB-GENEPAGE-478858

Gene Symbol: mycn Gene Name: MYCN proto-oncogene, bHLH transcription factor

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal brain ventricle morphology (1 source), abnormal eye morphology (1 source), abnormal head morphology (1 source), decreased size of the eye (1 source), poorly differentiated retinal ganglion cell (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: mycn manipulated (8 sources), mycn assayed (9 sources)
Computed annotations: mycn assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + mycn MO (8 sources), Xla Wt + Mmu.ascl1 + mycn (1 source), Xla Wt + Mmu.ascl1S62A,S88A,S185A,S189A,S202A,S218A + mycn (1 source), Xla Wt + mycn (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (38 sources): 2-3 toe syndactyly, 4-5 toe syndactyly, Accessory spleen, Annular pancreas, Anteverted nares, Aplasia/Hypoplasia of the middle phalanx of the 2nd finger, Aplasia/Hypoplasia of the middle phalanx of the 5th finger, Asplenia, Blepharophimosis, Decreased fetal movement, Depressed nasal tip, Duodenal atresia, Epicanthus, Esophageal atresia, Everted lower lip vermilion, Facial asymmetry, Hearing impairment, High palate, Intellectual disability, Low-set ears, Microcephaly, Micrognathia, Narrow palpebral fissure, Patent ductus arteriosus, Polyhydramnios, Polysplenia, Posteriorly rotated ears, Prominent occiput, Short palpebral fissure, Short toe, Small anterior fontanelle, Specific learning disability, Thick vermilion border, Tracheoesophageal fistula, Triangular face, Upslanted palpebral fissure, Vocal cord paralysis, Wide nasal bridge [+]
Mouse (84 sources): abnormal Wolffian duct morphology, abnormal angiogenesis, abnormal anterior cardinal vein morphology, abnormal apical ectodermal ridge morphology, abnormal branching involved in lung morphogenesis, abnormal cardiac epithelial to mesenchymal transition, abnormal cerebellar Purkinje cell layer, abnormal cerebellar foliation, abnormal cerebellar granule layer morphology, abnormal cerebellar molecular layer, abnormal cerebellum development, abnormal cerebellum external granule cell layer morphology, abnormal cerebral cortex morphology, abnormal cortical ventricular zone morphology, abnormal cranial ganglia morphology, abnormal dorsal aorta morphology, abnormal embryo development, abnormal embryonic neuroepithelial layer differentiation, abnormal embryonic neuroepithelium morphology, abnormal fetal cardiomyocyte proliferation, abnormal forebrain development, abnormal heart development, abnormal intestinal epithelium morphology, abnormal lens vesicle development, abnormal limb bud morphology, abnormal limb development, abnormal liver development, abnormal lung development, abnormal lung epithelium morphology, abnormal medulla oblongata morphology, abnormal mesonephric mesenchyme morphology, abnormal mesonephros morphology, abnormal neuron differentiation, abnormal neuronal precursor proliferation, abnormal optic vesicle formation, abnormal pulmonary alveolus epithelial cell morphology, abnormal vertebral body development, absent pulmonary alveoli, absent stomach, absent vitelline blood vessels, decreased Purkinje cell number, decreased body length, decreased brain size, decreased embryo size, decreased embryonic neuroepithelium thickness, decreased fetal size, decreased hematopoietic stem cell number, decreased neuronal precursor cell number, decreased survivor rate, decreased type I pneumocyte number, decreased type II pneumocyte number, dilated dorsal aorta, disorganized dorsal root ganglion, dorsal root ganglion hypoplasia, ectopic Purkinje cell, embryonic growth arrest, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, first pharyngeal arch hypoplasia, gonadal ridge hypoplasia, impaired branching involved in bronchus morphogenesis, increased hepatocyte apoptosis, kinked tail, liver hypoplasia, neonatal lethality, complete penetrance, neonatal lethality, incomplete penetrance, nervous system phenotype, no abnormal phenotype detected, no spontaneous movement, pale yolk sac, postnatal lethality, incomplete penetrance, premature neuronal precursor differentiation, prenatal lethality, complete penetrance, reproductive system phenotype, small cerebellum, small dorsal root ganglion, small heart, small kidney, small liver, small trigeminal ganglion, small vertebral body, thin myocardium, thin myocardium compact layer, trabecula carnea hypoplasia [+]
View all ortholog results at Monarch