Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (375) GO Terms (15) Nucleotides (209) Proteins (37) Interactants (1533) Wiki
XB-GENEPAGE-479317

notch1     notch 1 receptor

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal brain morphology (4 sources), abnormal development of notochord (4 sources), abnormal embryo morphology (3 sources), abnormally increased number of Rohon-Beard neuron (3 sources), abnormally decreased number of Rohon-Beard neuron (2 sources), absent Rohon-Beard neuron (2 sources), decreased cell population proliferation in spinal cord (2 sources), abnormal neural plate (1 source), abnormal neural tube morphology (1 source), abnormally increased number of apoptotic cell (1 source), abnormally increased number of neuron (1 source), absent notochord (1 source), decreased size of the notochord (1 source), decreased size of the proliferative region (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: notch1 manipulated (32 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + canotch1 (19 sources), Xla WT + notch1 ICD [unilateral] (6 sources), Xla WT + notch1 ICD [bilateral] (4 sources), Xla WT + rbpj-DBM RNA [unilateral] (3 sources), Xla WT + rbpj-DBM RNA+ [bilateral] (3 sources), Xla WT + rbpj-DBM RNA+ [bilateral] (2 sources), Xla Wt + canotch1-GR (2 sources), Xla Wt + notch1 (1 source), Xla Wt + canotch1 (1 source), Xla Wt + canotch1 (1 source), Xla Wt + canotch1 + DEX (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (74 sources): Abnormal left ventricular outflow tract morphology, Abnormal pulmonary valve morphology, Abnormality of the lower limb, Abnormality of the metacarpal bones, Abnormality of the upper limb, Absent fingernail, Absent hand, Aortic arch aneurysm, Aortic regurgitation, Aortic valve calcification, [+]
Mouse (140 sources): Meibomian gland degeneration, abnormal CD8-positive, alpha-beta T cell differentiation, abnormal T cell differentiation, abnormal T cell receptor beta chain V(D)J recombination, abnormal angiogenesis, abnormal anterior cardinal vein morphology, abnormal apoptosis, abnormal artery morphology, abnormal atrioventricular cushion morphology, abnormal bone marrow cavity morphology, [+]

View all ortholog results at Monarch