| Monarch Ortholog Phenotypes
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Human (9 sources):
Decreased circulating IgA level,
Decreased circulating IgG level,
Immunodeficiency,
Impaired Ig class switch recombination,
Lymphadenopathy,
Recurrent bacterial infections,
Recurrent infection of the gastrointestinal tract,
Recurrent respiratory infections,
Recurrent upper and lower respiratory tract infections
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Mouse (22 sources):
abnormal class switch recombination,
abnormal gut flora balance,
abnormal humoral immune response,
abnormal mean corpuscular hemoglobin,
abnormal mean corpuscular hemoglobin concentration,
abnormal somatic hypermutation frequency,
chromosomal instability,
decreased IgG1 level,
decreased IgG2a level,
decreased IgG2b level,
decreased IgG3 level,
decreased circulating glucose level,
decreased follicular B cell number,
decreased late germinal center B cell number,
immune system phenotype,
increased circulating fructosamine level,
increased early germinal center B cell number,
increased germinal center B cell number,
increased mean corpuscular hemoglobin,
increased mean corpuscular hemoglobin concentration,
increased susceptibility to bacterial infection induced morbidity/mortality,
no abnormal phenotype detected
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.