Monarch Ortholog Phenotypes
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Human (15 sources):
Abnormal thrombosis,
Arterial intimal fibrosis,
Dyspnea,
Elevated jugular venous pressure,
Elevated right atrial pressure,
Hypertension,
Increased pulmonary vascular resistance,
Pulmonary arterial hypertension,
Pulmonary arterial medial hypertrophy,
Pulmonary artery vasoconstriction,
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Mouse (46 sources):
abnormal egg cylinder morphology,
abnormal embryonic epiblast morphology,
abnormal embryonic-extraembryonic boundary morphology,
abnormal hair medulla,
abnormal hair medullary septa cells,
abnormal hair shaft melanin granule distribution,
abnormal leukocyte physiology,
abnormal lung thrombosis,
abnormal lung vasculature morphology,
abnormal myocardium compact layer morphology,
abnormal ophthalmic nerve morphology,
abnormal pulmonary alveolus morphology,
abnormal rostral-caudal axis patterning,
abnormal semilunar valve morphology,
abnormal sternocostal joint morphology,
abnormal vascular smooth muscle physiology,
absent heart valves,
absent mesoderm,
absent vitelline blood vessels,
artery occlusion,
atrioventricular septal defect,
cardiovascular system phenotype,
delayed bone ossification,
disorganized embryonic tissue,
disorganized extraembryonic tissue,
embryonic growth arrest,
embryonic growth retardation,
embryonic lethality between implantation and placentation, incomplete penetrance,
embryonic lethality between implantation and somite formation, complete penetrance,
embryonic lethality during organogenesis, complete penetrance,
failure of primitive streak formation,
failure to gastrulate,
increased lung endothelial cell proliferation,
increased right ventricle systolic pressure,
increased vascular permeability,
increased vasoconstriction,
integument phenotype,
lethality, complete penetrance,
lethality throughout fetal growth and development, complete penetrance,
nervous system phenotype,
no abnormal phenotype detected,
perinatal lethality, incomplete penetrance,
persistent truncus arteriosus type i,
persistent truncus arteriosus type iv,
prenatal lethality, incomplete penetrance,
vertebral transformation
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View all ortholog results at Monarch
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