bmpr2 Phenotypes

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Phenotypes

Gene Literature (27)

Nucleotides (137)

Interactants (246)

XB-GENEPAGE-479989

Gene Symbol: bmpr2 Gene Name: bone morphogenetic protein receptor type II

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: bmpr2 assayed (6 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (15 sources): Abnormal thrombosis, Arterial intimal fibrosis, Dyspnea, Elevated jugular venous pressure, Elevated right atrial pressure, Hypertension, Increased pulmonary vascular resistance, Pulmonary arterial hypertension, Pulmonary arterial medial hypertrophy, Pulmonary artery vasoconstriction, Pulmonary aterial intimal fibrosis, Pulmonary venous occlusion, Right ventricular failure, Right ventricular hypertrophy, Telangiectasia [+]
Mouse (46 sources): abnormal egg cylinder morphology, abnormal embryonic epiblast morphology, abnormal embryonic-extraembryonic boundary morphology, abnormal hair medulla, abnormal hair medullary septa cells, abnormal hair shaft melanin granule distribution, abnormal leukocyte physiology, abnormal lung thrombosis, abnormal lung vasculature morphology, abnormal myocardium compact layer morphology, abnormal ophthalmic nerve morphology, abnormal pulmonary alveolus morphology, abnormal rostral-caudal axis patterning, abnormal semilunar valve morphology, abnormal sternocostal joint morphology, abnormal vascular smooth muscle physiology, absent heart valves, absent mesoderm, absent vitelline blood vessels, artery occlusion, atrioventricular septal defect, cardiovascular system phenotype, delayed bone ossification, disorganized embryonic tissue, disorganized extraembryonic tissue, embryonic growth arrest, embryonic growth retardation, embryonic lethality between implantation and placentation, incomplete penetrance, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, failure of primitive streak formation, failure to gastrulate, increased lung endothelial cell proliferation, increased right ventricle systolic pressure, increased vascular permeability, increased vasoconstriction, integument phenotype, lethality throughout fetal growth and development, complete penetrance, lethality, complete penetrance, nervous system phenotype, no abnormal phenotype detected, perinatal lethality, incomplete penetrance, persistent truncus arteriosus type i, persistent truncus arteriosus type iv, prenatal lethality, incomplete penetrance, vertebral transformation [+]
View all ortholog results at Monarch