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Summary Expression Phenotypes Gene Literature (95) GO Terms (12) Nucleotides (125) Proteins (42) Interactants (994) Wiki
XB-GENEPAGE-480716

six1     SIX homeobox 1

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the inner ear (6 sources), decreased size of the otic capsule (3 sources), decreased size of the posterior semicircular canal (2 sources), decreased size of the lateral semicircular canal (1 source), decreased size of the utricle (1 source), increased size of the otic vesicle (1 source), increased size of the posterior semicircular canal (1 source), increased size of the utricle (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: six1 manipulated (136 sources), six1 assayed (32 sources)
Computed annotations: six1 assayed (29 sources)
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
branchiootorenal syndrome (16AP sources, 68 EP sources), branchiootic syndrome (15AP sources, 58 EP sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + six1 (14 sources), Xla Wt + Six1-Y129C (14 sources), Xla Wt + six1 (12 sources), Xla Wt + six1 MO (12 sources), Xla Wt + six1-V17E (12 sources), Xla Wt + six1-W122R (12 sources), Xla Wt + six1-R110W (9 sources), Xla Wt + six1 MO (7 sources), Xla Wt + mcrs1 + six1 (6 sources), Xla Wt + mcrs1 + six1 MO (6 sources), Xla Wt + mcrs1 MO + six1 MO (6 sources), Xla Wt + six1 (6 sources), Xla Wt + six1 (5 sources), Xla Wt + six1-150 (4 sources), Xla Wt + irx1 + Six1 MO (3 sources), Xla Wt + six1 MO (3 sources), Xla Wt + six1-400 (3 sources), Xla Wt + six1-VP16 (3 sources), Xla Wt + six1 + eya1 (2 sources), Xla Wt + six1-EnR (2 sources), Xla Wt + six1-GR + Dex (16) (2 sources), Xla Wt + mcrs1 + six1 MO (1 source), Xla Wt + six1 (1 source), Xla Wt + six1-EnR (1 source), Xla Wt + six1-GR + Dex (18) (1 source), Xla Wt + six1-R110W (1 source), Xla Wt + six1-VP16 (1 source), Xla Wt + six1-W122R (1 source), Xtr Wt + six1 CRISPR (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (32 sources): Abnormal lacrimal duct morphology, Abnormal nasolacrimal system morphology, Abnormality of the inner ear, Abnormality of the middle ear ossicles, Abnormality of the outer ear, Atresia of the external auditory canal, Branchial cyst, Branchial fistula, Cleft palate, Commissural lip pit, [+]
Mouse (97 sources): abnormal Meckel's cartilage morphology, abnormal abdominal wall morphology, abnormal cardiac outflow tract development, abnormal cardiovascular development, abnormal cochlea morphology, abnormal cochlear hair cell morphology, abnormal common carotid artery morphology, abnormal common crus morphology, abnormal cranial neural crest cell morphology, abnormal craniofacial bone morphology, [+]

View all ortholog results at Monarch