shox2 Phenotypes

Phenotypes

XB-GENEPAGE-480992

Gene Symbol: shox2 Gene Name: SHOX homeobox 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
absent head (2 sources), decreased size of the eye (2 sources), decreased size of the head (2 sources), decreased size of the tail (2 sources), partially ventralized embryo (2 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: shox2 assayed (1 source)
Computed annotations: shox2 assayed (2 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + Hsa.SHOX2 (1 source), Xtr Wt + shox2 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (32 sources): abnormal allantois morphology, abnormal cardiac output, abnormal cartilage development, abnormal forelimb stylopod morphology, abnormal heart development, abnormal hindlimb stylopod morphology, abnormal hindlimb zeugopod morphology, abnormal limb morphology, abnormal long bone epiphyseal plate morphology, abnormal palatal shelf fusion at midline, abnormal secondary palate development, abnormal sinoatrial node morphology, abnormal sinus venosus morphology, abnormal somite shape, abnormal temporomandibular joint disk morphology, cardiovascular system phenotype, craniofacial phenotype, decreased birth body size, decreased birth weight, decreased heart left ventricle size, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, increased cardiac output, lethality throughout fetal growth and development, complete penetrance, lethality throughout fetal growth and development, incomplete penetrance, limbs/digits/tail phenotype, pericardial edema, postnatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, prenatal lethality prior to heart atrial septation, preweaning lethality, complete penetrance, slow postnatal weight gain [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (32 sources): abnormal allantois morphology, abnormal cardiac output, abnormal cartilage development, abnormal forelimb stylopod morphology, abnormal heart development, abnormal hindlimb stylopod morphology, abnormal hindlimb zeugopod morphology, abnormal limb morphology, abnormal long bone epiphyseal plate morphology, abnormal palatal shelf fusion at midline, [+]