emx2 Phenotypes

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Phenotypes

Gene Literature (30)

Nucleotides (114)

Interactants (309)

XB-GENEPAGE-481027

Gene Symbol: emx2 Gene Name: empty spiracles homeobox 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: emx2 assayed (10 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (13 sources): Agenesis of corpus callosum, Aplasia/Hypoplasia of the corpus callosum, Cerebral cortical atrophy, EEG abnormality, Global developmental delay, Hemiparesis, Intellectual disability, Porencephalic cyst, Schizencephaly, Seizure, Spasticity, Spastic tetraplegia, Strabismus [+]
Mouse (53 sources): abnormal Ammon gyrus morphology, abnormal axon extension, abnormal cerebral cortex morphology, abnormal cerebral hemisphere morphology, abnormal cochlea morphology, abnormal cochlear inner hair cell morphology, abnormal hippocampal fimbria morphology, abnormal incudomalleolar joint morphology, abnormal incudostapedial joint morphology, abnormal incus long process morphology, abnormal incus morphology, abnormal kidney development, abnormal malleus morphology, abnormal metanephric mesenchyme morphology, abnormal metanephric ureteric bud development, abnormal middle ear ossicle morphology, abnormal pallium development, abnormal primary sex determination, abnormal stapes head morphology, abnormal ureteric bud tip morphology, absent dentate gyrus, absent efferent ductules of testis, absent epididymis, absent incus, absent incus lenticular process, absent internal female genitalia, absent internal male genitalia, absent Mullerian ducts, absent oviduct, absent pinna reflex, absent seminal vesicle, absent testes, absent ureter, agonadal, cardiovascular system phenotype, conductive hearing loss, deafness, decreased anterior commissure size, decreased cochlear nerve compound action potential, decreased corpus callosum size, decreased hippocampal fornix size, gonadal ridge hypoplasia, impaired branching involved in ureteric bud morphogenesis, increased cochlear inner hair cell number, increased cochlear nerve compound action potential, increased cochlear outer hair cell number, increased metanephric mesenchyme apoptosis, neonatal lethality, complete penetrance, sensorineural hearing loss, small kidney, small olfactory bulb, syndromic hearing loss, Wolffian duct degeneration [+]
View all ortholog results at Monarch