abnormal lymph organ development, abnormal salivary gland physiology, abnormal splenic cell ratio, abnormal susceptibility to Picornaviridae infection, absent Peyer's patches, absent lymph nodes, behavior/neurological phenotype, colonic necrosis, decreased B-2 B cell number, decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased IgG2c level, decreased IgG3 level, decreased double-negative T cell number, decreased double-positive T cell number, decreased interferon-gamma secretion, decreased interleukin-10 secretion, decreased response to antigen, decreased salivation, decreased susceptibility to experimental autoimmune encephalomyelitis, decreased thymocyte number, decreased thymus weight, impaired humoral immune response, increased B-1a cell number, increased B-1b cell number, increased CD8-positive, alpha-beta T cell number, increased T cell apoptosis, increased anti-nuclear antigen antibody level, increased autoantibody level, increased double-negative T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased interferon-gamma secretion, increased interleukin-17 secretion, increased susceptibility to autoimmune disorder, increased susceptibility to bacterial infection induced morbidity/mortality, increased thymocyte apoptosis, lacrimal gland inflammation, salivary gland inflammation, small inguinal lymph nodes